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Listar por autor "Martínez-Poveda, Beatriz"
Mostrando ítems 1-20 de 44
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A Proteomic Study of the Bioactivity of Annona muricata Leaf Extracts in HT-1080 Fibrosarcoma Cells.
Marrero Capitán, Ana Dácil; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Cárdenas, Casimiro (MDPI, 2023-07-27)Graviola (Annona muricata) is a tropical plant with many traditional ethnobotanic uses and pharmacologic applications. A metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves recently allowed ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
El análogo de las estrigolactonas GR-24 inhibe la angiogénesis in vitro e in vivo
Carrillo Fernández, Paloma; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2016-10-03)Muchas fitohormonas han mostrado un gran potencial en la prevención y terapia contra el cáncer. Las estrigolactonas son hormonas vegetales derivadas de los caroteinoides que están implicadas en la inhibición de la ramificación ... -
Angioprevention of Urologic Cancers by Plant-Derived Foods.
García-Caballero, Melissa; Torres-Vargas, José Antonio; Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2022-01-21)The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney ... -
Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero Capitán, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal-Valenzuela, Isabel; Rodríguez-Quesada, Ana María; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
Anti-inflammatory potential of aeroplysinin-1, a bioactive compound isolated from the sponge Aplysina aerophoba
Bravo-Ruiz, Inés; Bernal, Manuel; Manrique-Poyato, Maria Inmaculada; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Castilla, Laura; Martínez-Póveda, Beatriz Amparo[et al.] (43 Congreso Anual SEBBM, 2021)Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that has been shown to possess bioactive effects with a broad spectrum of action in in vitro and in vivo assays. Included ... -
Antiangiogenic potential of an olive oil extract: insights from a proteomic study
Marrero Capitán, Ana Dácil; Cárdenas García, Casimiro; Castilla, Laura; Ortega Vidal, Juan; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (ACS, 2024)Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects ... -
Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernández, Paloma; Cheng-Sánchez, Iván; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; Rodríguez-Quesada, Ana María[et al.] (2017-11-09)In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
Búsqueda y caracterización de nuevos candidatos a fármacos inhibidores de la angiogénesis
Carrillo Fernández, Paloma (Uma Editorial, 2019-10)La presente Tesis Doctoral se ha realizado en el grupo de investigación dedicado a la búsqueda y caracterización de nuevos fármacos antiangiogénicos del Departamento de Biología Molecular y Bioquímica de la Universidad de ... -
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, José Antonio; Cheng-Sánchez, Iván; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; García-Caballero, Melissa; Rodríguez-Quesada, Ana María[et al.] (Elsevier, 2022-09-30)The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero Capitán, Ana Dácil; Castilla, Laura; Espartero Sánchez, José Luis; Madrona, Andrés; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (2020-09-22)The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
El análogo de las estrigolactonas GR-24 induce cambios en el citoesqueleto de células tumorales y endoteliales y modula su balance rédox
Torres-Vargas, José Antonio; Martínez-Póveda, Beatriz Amparo; Carrillo Fernández, Paloma; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2018-12-12)Las estrigolactonas son hormonas vegetales con estructura terpenoide, implicadas en el control de una serie de procesos que incluyen la inhibición de la ramificación de la raíz y el brote. Recientemente, se ha descrito el ... -
Estudios de preferencia metabólica en células del “microambiente angiogénico”
Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2016-10-03)El "redescubrimiento" del efecto Warburg a principios de este siglo XXI y de la elevada glutaminolisis tumoral han contribuido a un renovado interés por el metabolismo en Oncología. Además, estudios recientes han dado ... -
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention
Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Carrillo Fernández, Paloma; Urdiales-Ruiz, José Luis; Serrano, José J.; Montañez, Raúl; Rodríguez-Quesada, Ana María[et al.] (2017-08-29)The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ... -
Evaluation of the anti-angiogenic potential of hydroxytyrosol derivatives
Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Castilla, Laura; Gallardo, Elena; Espartero Sánchez, José Luis; Carrillo Fernández, Paloma; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel[et al.] (2018-09-19)Angiogenesis, a process which allows the formation of new vessels from pre-existing ones, is an essential phenomenon for tumor survival since it allows cancer cells to obtain nutrients and oxygen. This explains the increasing ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Carrillo Fernández, Paloma; Rodríguez-Quesada, Ana María; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón[et al.] (2018-10-19)New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis
Ocaña Farfán, María del Carmen; Carrillo Fernández, Paloma; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2017-10-31)The role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic ... -
Gastronomía Bioactiva: compuestos bioactivos en alimentos y quimioprevención en enfermedades de alta prevalencia
Martínez-Póveda, Beatriz Amparo; Marrero Capitán, Ana Dácil; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (43 Congreso Anual SEBBM, 2021)La quimioprevención de enfermedades basada en la dieta ha surgido en los últimos años como un enfoque interesante para la prevención, e incluso la ralentización de fases iniciales, en patologías de alta prevalencia como ... -
Identification and characterization of new anti-angiogenic compounds from natural sources
Carrillo Fernández, Paloma; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2017-07-21)The inhibition of angiogenesis has attracted broad attention in the field of pharmacological research, not only for cancer, but for other angiogenesis dependent diseases including ophthalmic, cutaneous and inflammatory ... -
Inhibition of Endothelial Inflammatory Response by HT-C6, a Hydroxytyrosol Alkyl Ether Derivative.
Marrero Capitán, Ana Dácil; Castilla, Laura; Bernal, Manuel; Manrique-Poyato, María Inmaculada; Posligua-García, Joel; Moya-Utrera, Federico; Porras Alcalá, Cristina; Espartero Sánchez, José Luis; Sarabia-García, Francisco Ramón; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (MDPI, 2023-07-28)Hydroxytyrosol (HT) is a bioactive phenolic compound naturally present in olives and extra virgin olive oil (EVOO) which is described as an antioxidant, antitumoral and antiangiogenic molecule. Previous studies of ...