Listar por autor "Ocaña Farfán, María del Carmen"
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Antitumor and antiangiogenic potential of solomonamide synthesis intermediates
Carrillo Fernández, Paloma; Cheng-Sánchez, Iván; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo
; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; Rodríguez-Quesada, Ana María[et al.] (2017-11-09)
In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ... -
Estudios de preferencia metabólica en células del “microambiente angiogénico”
Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2016-10-03)
El "redescubrimiento" del efecto Warburg a principios de este siglo XXI y de la elevada glutaminolisis tumoral han contribuido a un renovado interés por el metabolismo en Oncología. Además, estudios recientes han dado ... -
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention
Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Carrillo Fernández, Paloma; Urdiales-Ruiz, José Luis; Serrano, José J.; Montañez, Raúl; Rodríguez-Quesada, Ana María[et al.] (2017-08-29)
The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ... -
Fasentin, a glucose uptake inhibitor, is also able to inhibit angiogenesis
Ocaña Farfán, María del Carmen; Carrillo Fernández, Paloma; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2017-10-31)
The role of glucose on endothelial cell (EC) metabolism and angiogenesis has been an emerging issue in the last few years. Some inhibitors of glucose metabolism, such as 2-deoxyglucose, have been shown to have anti-angiogenic ... -
The graphene oxide species induce a different biological response in SN4741 Parkinson cell line
Rodríguez-Losada, Noela; Wendelbo, Rune; Aguirre-Gómez, José Ángel; Ocaña Farfán, María del Carmen; Arráez-Sánchez, Miguel Ángel; Díaz-Casares, Amelia; Medina-Torres, Miguel Ángel; Martínez-Moreno, José Manuel; Arenas, Ernest; Narváez-Bueno, José Ángel[et al.] (2019-09-30)
Introduction: Graphene Oxide (GO)has recently emerged as a reliable material to create scaffolds for the neural tissue because of its biocompatibility, electroconductive and physicochemical properties. Graphene is a ... -
Identification and characterization of new anti-angiogenic compounds from natural sources
Carrillo Fernández, Paloma; Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2017-07-21)
The inhibition of angiogenesis has attracted broad attention in the field of pharmacological research, not only for cancer, but for other angiogenesis dependent diseases including ophthalmic, cutaneous and inflammatory ... -
Interplay between glucose and palmitate uptake in breast carcinoma in vitro
Ocaña Farfán, María del Carmen; Carrillo Fernández, Paloma; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2018-07-17)
One of the most studied tumor cells lines in vitro is the breast carcinoma MDA-MB-231 cell line. Several studies have proved its glycolytic profile, namely known as the Warburg effect. Glutamine oxidation is also important ... -
Lactate Oxidation in Endothelial Cells: A Feature of All Endothelial Cells?
Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2019-04-24)
Metabolism of endothelial cells is a topic that has gained an increasing interest in the last years. This is due to their role in the angiogenic process, which is pathologically upregulated in several diseases, such as ... -
Metabolic preference studies in cells of the tumor microenvironment
Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2016-10-03)
In the last years, the rediscovery of the Warburg effect and high tumoral glutaminolysis has lead to a renewed interest in cancer metabolism. Moreover, recent studies have put some importance in endothelial cells metabolism. ... -
Metabolic studies within the angiogenic microenvironment as a potential target for the treatment of cancer and other angiogenesis dependent diseases
(UMA Editorial, 2020-09-24)La angiogénesis es el proceso de formación de vasos sanguíneos a partir del lecho vascular preexistente. Una angiogénesis insuficiente o excesiva puede llevar al desarrollo de diversas patologías, entre las que se incluye ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodríguez-Quesada, Ana María (2018-10-19)
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
Role of glucose, glutamine and palmitate in endothelial and tumor metabolism
Ocaña Farfán, María del Carmen; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2016-12-22)
Glucose and glutamine are the major sources of energy for mammalian cells. In tumors, Warburg effect and glutaminolysis have been largely studied. On the other hand, a major role of glucose in angiogenesis has been ... -
Synthesis, characterization and biological evaluation of octyltrimethylammonium tetrathiotungstate
Vega-Granados, Karla; Cruz-Reyes, Juan; Horta-Marrón, José F.; Mari-Beffa, Manuel; Díaz-Rubio, Laura; Córdova-Guerrero, Iván; Chávez-Velasco, Daniel; Ocaña Farfán, María del Carmen; Medina-Torres, Miguel Ángel; Romero-Sánchez, Lilian B.[et al.] (Springer Nature, 2021)
Octyltrimethylammonium tetrathiotungstate salt (ATT-C8) was synthesized and its ability to chelate copper was evaluated. The biological and toxic aspects were evaluated by in vitro and in vivo assays, using bovine aorta ...