Listar por autor "Castilla, Laura"
Mostrando ítems 1-13 de 13
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Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero Capitán, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal-Valenzuela, Isabel; Rodríguez-Quesada, Ana María
; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)
Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
Anti-inflammatory potential of aeroplysinin-1, a bioactive compound isolated from the sponge Aplysina aerophoba
Bravo-Ruiz, Inés; Bernal, Manuel; Manrique-Poyato, Maria Inmaculada; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Castilla, Laura; Martínez-Póveda, Beatriz Amparo[et al.] (43 Congreso Anual SEBBM, 2021)
Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that has been shown to possess bioactive effects with a broad spectrum of action in in vitro and in vivo assays. Included ... -
Antiangiogenic potential of an olive oil extract: insights from a proteomic study
Marrero Capitán, Ana Dácil; Cárdenas García, Casimiro; Castilla, Laura; Ortega Vidal, Juan; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (ACS, 2024)
Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero Capitán, Ana Dácil; Castilla, Laura; Espartero Sánchez, José Luis; Madrona, Andrés; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (2020-09-22)
The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Evaluation of the anti-angiogenic potential of hydroxytyrosol derivatives
Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Castilla, Laura; Gallardo, Elena; Espartero Sánchez, José Luis; Carrillo Fernández, Paloma; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel[et al.] (2018-09-19)
Angiogenesis, a process which allows the formation of new vessels from pre-existing ones, is an essential phenomenon for tumor survival since it allows cancer cells to obtain nutrients and oxygen. This explains the increasing ... -
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
Peñalver Alonso, Ana; Campos-Sandoval, José Ángel; Blanco-Calvo, Eduardo; Cardona Ramírez, Carolina; Castilla, Laura; Martín-Rufián, Mercedes; Estivill-Torrús, Guillermo; Sánchez-Varo, Raquel María; Alonso-Carrión, Francisco José; Pérez-Hernández, Mercedes; Colado, María Isabel; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (Frontiers, 2017-09-05)
Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor ... -
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Márquez-Torres, Clara; Urbano-Polo, Nieves; Brøndegaard, David; Martín-Rufián, Mercedes; Lobo, Carolina; Peñalver Alonso, Ana; Gómez García, María del Carmen; Martín-Campos, Janet; Cardona Ramírez, Carolina; Castilla, Laura; Da-Costa-Souza, Felipe; Cheng, Tzuling; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Curi, Rui; Colquhoun, Alison; DeBerardinis, Ralph J; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel[et al.] (BMC, 2021-02-20)
Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated ... -
Inhibition of Endothelial Inflammatory Response by HT-C6, a Hydroxytyrosol Alkyl Ether Derivative.
Marrero Capitán, Ana Dácil; Castilla, Laura; Bernal, Manuel; Manrique-Poyato, María Inmaculada; Posligua-García, Joel; Moya-Utrera, Federico; Porras Alcalá, Cristina; Espartero Sánchez, José Luis; Sarabia-García, Francisco Ramón; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (MDPI, 2023-07-28)
Hydroxytyrosol (HT) is a bioactive phenolic compound naturally present in olives and extra virgin olive oil (EVOO) which is described as an antioxidant, antitumoral and antiangiogenic molecule. Previous studies of ... -
Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation
López de la Oliva, Amada; Campos-Sandoval, José A.; Gómez-García, María Carmen; Cardona, Carolina; Martín-Rufián, Mercedes; Sialana, Fernando J.; Castilla, Laura; Bae, Narkhyun; Lobo, Carolina; Peñalver, Ana; García-Frutos, Marina; Carro, David; Enrique, Victoria; Paz-Gutiérrez, José Carlos; Mirmira, Raghavendra G.; Gutiérrez, Antonia; Alonso-Carrión, Francisco José; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Lubec, Gert; Márquez-Gómez, Javier[et al.] (Nature Portfolio, 2020-02-10)
Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis playing a key role in cancer metabolic reprogramming. Humans express two types of GA isoforms: GLS and GLS2. GLS isozymes have been consistently ... -
Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus
García-Bonilla, María; Shumilov, Kirill; Peñalver, Ana; Castilla, Laura; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; García-Martín, María Luisa; Muñoz, Carmen; Gutiérrez-Pérez, Antonia; Jiménez-Lara, Antonio Jesús[et al.] (2016-07-11)
Background Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative ... -
Ratones knock-out del receptor lpa1 de ácido lisofosfatídico presentan un acusado déficit de la isoenzima glutaminasa KGA (GLS) y una morfología alterada en las espinas dendríticas de hipocampo y corteza
Peñalver, Ana; Campos-Sandoval, José Ángel; Sánchez-Varo, Raquel María; Cardona Ramírez, Carolina; Castilla, Laura; Blanco, Eduardo; Martín-Rufián, Mercedes; Segura-Checa, Juan Antonio; Mates-Sánchez, José Manuel; Alonso-Carrión, Francisco José; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (2015-09-25)
Objectives: The objective of the present study was to utilize mice with knocked-down lysophosphatidic acid 1 (LPA1) receptor to ascertain changes in glutamatergic transmission that may help to explain part of the cognitive ... -
The immunomodulator dimethyl taconite inhibits several key steps of angiogenesis in cultured endothelial cells
Vidal-Valenzuela, Isabel; Fernández-Florido, Elena; Marrero Capitán, Ana Dácil; Castilla, Laura; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (2022)
Dimethyl itaconate (DMI) is a cell-permeable derivative of itaconate, a known immunomodulator metabolite synthesized from the Krebs cycle intermediate cis-aconitate by the enzyme aconitate dehydrogenase. Although DMI is ... -
The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer
Carrillo Fernández, Paloma; Bernal Muñoz, Manuel; Téllez Quijorna, Clara; Marrero Capitán, Ana Dácil; Vidal-Valenzuela, Isabel; Castilla, Laura; Caro Salazar, Carlos; Domínguez Moreno, Alejandro; García-Martín, María Luisa; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (Elsevier, 2022-12-14)
Stauprimide, a semi-synthetic derivative of staurosporine, is known mainly for its potent differentiation-enhancing properties in embryonic stem cells. Here, we studied the effects of stauprimide in cell growth and migration ...