Listar por autor "Valpuesta-Fernández, María"
Mostrando ítems 1-13 de 13
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Adsorbatos isoquinolínicos y benzazepínicos: síntesis e incorporación a superficies de silicio y nanopartículas
(UMA Editorial, 2019)La mayoría de los productos farmacéuticos aprobados por la FDA presentan en su estructura átomos de nitrógeno. De hecho, más de la mitad de ellos incluyen un heterociclo de nitrógeno. Entre los heterociclos de nitrógeno ... -
Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors
Valpuesta-Fernández, María
; Lucena-Serrano, Cristina; Rivera-Ramírez, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; Díaz-Morilla, Amelia[et al.] (2016-10-14)
The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ... -
Diastereoselective synthesis of chiral amines by imines alkylation
Díaz-Morilla, Amelia; Muñoz, Carmen; Sánchez, María; Valpuesta-Fernández, María (2013-10-03)
En esta comunicación se aborda la síntesis de aminas quirales utilizando como agente alquilante trietilborano. -
Presentación [de la exposición 40 años de la Biblioteca (...)]
Valpuesta-Fernández, María (Universidad de Málaga, Biblioteca, 2013)
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Síntesis de tetrahidroisoquinolinas y tetrahidro-3-benzazepinas. Evaluación de su actividad dopaminérgica.
(Publicaciones y Divulgación Científica. Universidad de Málaga, 2020)Las tetrahidro-3-benzazepinas (THBs) son una clase de compuestos heterocíclicos que se caracterizan por la presencia en su estructura de un anillo bencénico condensado con un anillo de azepina. La importancia de estos ... -
SPION Nanoparticles for Delivery of Dopaminergic Isoquinoline and Benzazepine Derivatives.
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; Díaz-Morilla, Amelia; Valpuesta-Fernández, María; Villaverde, Gonzalo; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón; Laurenti, Marco; Rubio Retama, Jorge; Contreras-Cáceres, Rafael[et al.] (Elsevier, 2022-06-27)
Superparamagnetic iron nanoparticles (SPIONs) have become one of the most useful colloidal systems in nanomedicine. We report here the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with ... -
Study and characterization of modified silicon surfaces with organic molecules
Valpuesta-Fernández, María; Sánchez-Molina, María; Lucena-Serrano, Ana; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; Díaz-Morilla, Amelia[et al.] (2016-10-14)
Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows ... -
Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines.
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; Rivera-Ramírez, Alicia; López-Romero, Juan Manuel; Valpuesta-Fernández, María; Díaz-Morilla, Amelia[et al.] (Elsevier, 2018-07-05)
A series of new 1-aryl-6,7-dihydroxy tetrahydroisoquinolines with several substitution patterns in the 1-aryl group at C-1 were prepared in good yields. The influence of each substituent on the affinity and selectivity for ... -
Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines
Lucena-Serrano, Ana; Lucena-Serrano, Cristina; López-Romero, Juan Manuel; Díaz-Morilla, Amelia; Valpuesta-Fernández, María (2017-07-20)
The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. ... -
Synthesis of bioactive compounds. Studies of their attachment to nanoparticles
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; López-Romero, Juan Manuel; Díaz-Morilla, Amelia; Valpuesta-Fernández, María (2017-07-20)
The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of ... -
Transformaciones, reactividad y síntesis de protopinas
Díaz-Morilla, Amelia (Universidad de Málaga, Servicio de Publicaciones, 2003)
Esta tesis se enmarca dentro del campo de los alcaloides isoquinolínicos. La búsqueda de nuevas estructuras, el estudio de reactividad y sintesis, su posible actividad biológica y otros aspectos relacionados con su ... -
Tripod-shaped penta (p-phenylene)s for the functionalization of silicon surfaces
Sánchez-Molina, María; Contreras-Cáceres, Rafael; Díaz-Morilla, Amelia; Valpuesta-Fernández, María; López-Romero, Juan Manuel (2016-03-31)
In order to obtain nanostructured thin films to be used in biosensor devices, several chemical functionalization methods have been developed, such as Click chemistry or Suzuki carbon-carbon coupling reactions on surfaces.1 ... -
Tripodal penta(p-phenylene) for the biofunctionalization of alkynyl-modified silicon surfaces.
Sánchez-Molina, María; Díaz-Morilla, Amelia; Valpuesta-Fernández, María; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; López-Ramírez, María Rosa[et al.] (Elsevier, 2018-03-22)
Here we report the optimization on the covalent grafting methodology of a tripod-shaped penta(p-phenylene), 1, on alkynyl-terminated silicon surfaces, and the incorporation of an active theophylline derivative, 2, for the ...