Listar QO - Contribuciones a congresos científicos por fecha de publicación
Mostrando ítems 21-40 de 63
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New bodipy dyads for two-photons fluorescence imaging in cells
Collado-Martín, Daniel
(2016-09-13)
Fluorescent probes are essential tools for studying biological systems. The last decade has witnessed particular interest in the development of two-photon excitable probes, due to their advantageous features in tissue ... -
Synthesis of the Macrocylic Core of the Solomonamides, a New Class of Cyclopeptides of Marine Origin
(2016-09-29)Se describe estudios sintéticos dirigidos hacia la síntesis total de solomonamides, una nueva clase de ciclopéptidos de origen marino que presentan interesantes propiedades biológicas. La aproximación sintética se basó en ... -
Study and characterization of modified silicon surfaces with organic molecules
Valpuesta-Fernández, María; Sánchez-Molina, María; Lucena-Serrano, Ana; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; Díaz-Morilla, Amelia[et al.] (2016-10-14)
Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows ... -
Comparative study of dopaminergic activity of tetrahydro-1H-[3]-benzazepines and their precursors
Valpuesta-Fernández, María; Lucena-Serrano, Cristina; Rivera-Ramírez, Alicia; Contreras-Cáceres, Rafael; López-Romero, Juan Manuel; Díaz-Morilla, Amelia[et al.] (2016-10-14)
The discovery of the tetrahydro-1H-[3]-benzazepine SCH23390 [1], represented one of the most important advances in the study of dopaminergic receptors due to their behavior as a selective D1 receptor antagonist. The high ... -
New molecules based indolium for two-photon absortion bioimaging applications
Benítez-Martín, Carlos; Pérez-de-Inestrosa-Villatoro, Ezequiel; Nájera-Albendín, Francisco (Universidad de Extremadura, 2017)
The development of organic materials with 2PA has attracted intensive attention in the past two decades. In two-photon bio-imaging applications the design of the chromophore requires to have a good cross-section and good ... -
Synthesis and applications in biomedicine of new dendrimeric structures
Pérez-de-Inestrosa-Villatoro, Ezequiel (2017-06-20)
Specific cell interactions of surfaces grafted dendrimers have been applied to the study of cell adhesion. We have studied also the application of dendrimer-based uneven nanopatterns to evaluate the local RGD surface density ... -
Managing with (fluorescent)-biomimetic dendrimers
Pérez-de-Inestrosa-Villatoro, Ezequiel; Vida-Pol, Yolanda; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Mesa-Antunez, Pablo; Ruiz-Sanchez, Antonio Jesus; Molina, Noemi; Morgado, Anjara[et al.] (2017-06-30)
Dendrimers that are modified through their peripheral groups have been employed for many biomedical purposes. Diagnosis via specific interactions with target proteins is one of the objectives that has been given more ... -
Two-Photon Fluorescence As Tool For Imaging In Cells
Collado-Martín, Daniel (2017-06-30)
Fluorescent probes are essential tools for studying biological systems. The last decade has witnessed particular interest in the development of two-photon excitable probes, due to their advantageous features in tissue ... -
Synthesis of Molecular Tripods Functionalized with Thioacetate Groups. Model Molecules for Gold Substrates Nanostructuration
(2017-07-11)Self-assembled monolayers (SAMs) of thiols on gold surfaces have attracted widespread interest as they can serve as structural and/or functional parts of biosensors, drug-delivery systems, electronics devices, among other ... -
Synthesis of bioactive compounds. Studies of their attachment to nanoparticles
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; López-Romero, Juan Manuel; Díaz-Morilla, Amelia; Valpuesta-Fernández, María (2017-07-20)
The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of ... -
Synthesis of New Analogues of the Bengamides: Peptidyl Bengamides and Molecular Probes
Aguera-Suárez, Ana María; Porras Alcalá, Cristina; Guerrero Vásquez, Guillermo A.; Cheng-Sánchez, Iván; Sarabia-García, Francisco Ramón (2017-07-20)
Isolated from sponges of the Jaspidae family, first members where discovered in 1986. The bengamides represent an interesting and unprecedented family of natural products that displayed striking antitumor activities [1]. ... -
Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines
Lucena-Serrano, Ana; Lucena-Serrano, Cristina; López-Romero, Juan Manuel; Díaz-Morilla, Amelia; Valpuesta-Fernández, María (2017-07-20)
The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. ... -
Total synthesis of depudecin and analogues via an olefin cross-metathesis based strategy
Cheng-Sánchez, Iván; Sarabia-García, Francisco Ramón (2017-07-20)
(-)-Depudecin (1), isolated from the culture broths of the fungus Alternaria brassicicola [1], has been identified as a selective inhibitor of histone deacetylases (HDAC) with an IC50 in the low μM range. In contrast to ... -
Hybrid pH-Responsive Au@p4VP Microgels as Platform for Selective SERS Analysis
(2017-09-21)We present the synthesis a of pH-responsive core@shell hybrid microgel. This colloidal system is formed by a 55 nm Au core individually covered by a polymeric pH-sensitive shell of poly(4-vinylpyridine), that we denote as ... -
Diseño y síntesis de nuevos dendrímeros y dendrones. Aplicaciones en regeneración tisular
Vida-Pol, Yolanda; Molina, Noemi; Morgado, Anjara; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2018-03-06)
Los dendrímeros han generado un enorme interés debido a su particular estructura ramificada y su multivalencia. La extensa investigación que se ha llevado a cabo sobre este tipo de macromoléculas ha demostrado la naturaleza ... -
Diseño y síntesis de nuevos dendrímeros
Morgado, Anjara; Molina, Noemi; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2018-03-06)
Los dendrímeros son excelentes plataformas multifuncionales para una gran cantidad de diferentes aplicaciones. En particular, el desarrollo de nanoestructuras moleculares multivalentes, con tamaño y forma bien definida, ... -
Diseño y síntesis de nuevos dendrones para aplicaciones biomédicas
Molina, Noemi; Morgado, Anjara; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (2018-03-06)
Los dendrímeros han sido empleados en una gran variedad de aplicaciones, entre las que destacan las del campo de la biomedicina. Estas macromoléculas multivalentes ofrecen la posibilidad de incorporar múltiples funcionalidades ... -
Detecting hydroxyl radical with a new two-photon fluorescent probe in living cells
Nájera-Albendín, Francisco; Benítez-Martín, Carlos; Guadix-Domínguez, Juan Antonio; Pérez-Pomares, José María; Pérez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
Reactive oxygen species (ROS) are known to be involved in the onset and development of multiple diseases, including cancer, cardiovascular diseases, neurodegenerative diseases and diabetes among others. Generation of ROS ... -
Tuning pKa in new molecules based on indolines for two-photon absorption bioimaging applications
Benítez-Martín, Carlos; Nájera-Albendín, Francisco; Pérez-de-Inestrosa-Villatoro, Ezequiel (Real Sociedad Española de Química, 2018-06-20)
Fluorescence-based biosensors have become essential tools for modern biology, allowing real-time monitoring of biological processes within living cells. The differences between pH play a significant role in multiple ... -
Aminonaphtamiline-squaraine dyad: photophysical properties and bioimaging application
Collado-Martín, Daniel (2018-09-19)
Squaraines is an important part of the cyanine family which have high extinction coefficients, sharp absorption bands, and intense fluorescence spectra in the red and near infrared region in solution.[1] The unique electronic ...