QO - Artículos: Envíos recientes
Mostrando ítems 1-20 de 32
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An array of bengamide E analogues modified at the terminal olefinic position: Synthesis and antimor properties.
Martín-Gálvez, Francisca; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Valeriote, Frederick A.; Sarabia-García, Francisco Ramón
(Chemistry Europe · European Chemical Societies Publishing, 2013-03-19)
Based on our previously described synthetic strategy for bengamide E, a natural product of marine origin with antitumor activity, a small library of analogues modified at the terminal olefinic position was generated with ... -
An olefin metathesis approach towards the solomonamides.
Cheng-Sánchez, Iván; García-Ruiz, Cristina; Sarabia-García, Francisco Ramón (Elsevier, 2016)
A new synthetic strategy directed towards the solomonamides, a novel class of cyclopeptides of marine origin, has been developed utilizing an olefin metathesis reaction to form the [15]-membered ring contained in these ... -
Stereoselective total synthesis of (-)-Depudecin
The total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported. Characterized by a highly oxidized 11-carbon chain containing ... -
An olefin cross-metathesis approach to depudecin and stereoisomeric analogues
Cheng-Sánchez, Iván; García-Ruiz, Cristina; Guerrero Vásquez, Guillermo A.; Sarabia-García, Francisco Ramón (ACS, 2017)
A new total synthesis of the natural product (−)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the synthesis is the utilization of an olefin cross-metathesis strategy, ... -
Epi-, epoxy- and C2-modified bengamides: Synthesis and biological Evaluation
Sarabia-García, Francisco Ramón; Martín-Gálvez, Francisca; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Vivar García, Carlos (ACS, 2013)
With the objective of investigating the influence of structural modifications of the polyketide chain of the bengamides upon their antitumoral activities, we targeted the preparation of bengamide E analogues with modification ... -
Exploring the chemistry of epoxy amides for the synthesis of the 2"-epi-diazepanone core of liposidomycins and caprazamycins
Sarabia-García, Francisco Ramón; Vivar García, Carlos; García-Ruiz, Cristina; Martín Ortiz, Laura; Romero-Carrasco, Antonio (ACS, 2012)
New synthetic strategies have been explored for the synthesis of the structural core of liposidomycins and caprazamycins, an intriguing class of complex nucleoside-type antibiotics. This structural core is comprised of a ... -
Solid phase synthesis of globomycin and SF-1902 A5
The syntheses of the natural lipocyclodepsipeptide-type antibiotics globomycin and SF-1902 A5 are reported utilizing solid phase technology for the construction of the peptidic fragment and a new asymmetric methodology of ... -
Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges
García-Ruiz, Cristina; Sarabia-García, Francisco Ramón (MDPI, 2014)
Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures ... -
Synthesis, characterization and antitumor activity of a poly-4-Vinyl pyridine-co-cannabidiol polymer
Fuentes-Ríos, David; Moya-Utrera, Federico; Moreno, Javier; Mesas, Cristina; Doña Flores, Manuel; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel; Melguizo, Consolación; Prados, José[et al.] (Elsevier, 2024)
Due to its natural origin and numerous beneficial properties, cannabidiol (CBD), one of the major phytocannabinoids of the Cannabis sativa L., has attracted the attention of many research groups in recent years. In this ... -
New Insights into Acylhydrazones E/Z isomerization: An Experimental and Theoretical Approach.
Fernández-Palacios, Sara; Matamoros, Esther; Morato Rojas, Isabel; López Navarrete, Juan T.; Ruiz-Delgado, María del Carmen; Vida-Pol, Yolanda; Perez-Inestrosa, Ezequiel[et al.] (MDPI, 2023)
A family of acylhydrazones have been prepared and characterized with the aim of investigating their potential as information storage systems. Their well stablished synthetic methodologies allowed the preparation of seven ... -
Multiepitope Dendrimeric Antigen-Silica particle composites as nano-based platforms for specific recognition of IgEs
Gil-Ocaña, Violeta; Jimenez, Isabel M.; Mayorga, Cristobalina; Doña, Inmaculada; Cespedes, Jose A.; Montañez, Maria I.; Vida-Pol, Yolanda; Torres, Maria J.; Perez-Inestrosa, Ezequiel[et al.] (Frontiers, 2021)
β-lactam antibiotics (BLs) are the drugs most frequently involved in drug hypersensitivity reactions. However, current in vitro diagnostic tests have limited sensitivity, partly due to a poor understanding of in vivo ... -
Amoxicillin Haptenation of Alpha-Enolase is Modulated by Active Site Occupancy and Acetylation.
Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel; González Morena, Juan Manuel; Sanchez Gomez, Francisco J; Salas, María; Montañez-Vega, María Isabel; Altomare, Alessandra; Aldini, Giancarlo; Pajares, Maria Angeles; Pérez-Sala, Dolores[et al.] (Frontiers, 2022)
Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the ... -
Dynamic Covalent Properties of a Novel Indolo[3,2-b]carbazole Diradical
Badía-Domínguez, Irene; Peña-Álvarez, Miriam; Wang, Deliang; Pérez Guardiola, Andrés; Vida-Pol, Yolanda; Rodríguez-González, Sandra; López Navarrete, Juan T.; Hernández-Jolín, Víctor; Sancho-García, Juan C.; García-Baonza, Valentín; Nash, Rosie; Hartl, František; Li, Hongxiang; Ruiz-Delgado, María del Carmen[et al.] (Wiley, 2021)
This work describes the synthesis and properties of a dicyanomethylene-substituted indolo[3,2-b]carbazole diradical ICz-CN. This quinoidal system dimerises almost completely to (ICz-CN)2, which contains two long C(sp3)−C(sp3) ... -
New approaches for Basophil Activation Tests employing Dendrimeric Antigen-Silica Nanoparticle composites.
Calvo-Serrano, Silvia; Matamoros, Esther; Céspedes, José Antonio; Fernández-Santamaría, Rubén; Gil-Ocaña, Violeta; Pérez-Inestrosa, Ezequiel; Frecha, Cecilia; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (MDPI, 2024-08-03)
In vitro detection of specific IgE bound to high-affinity receptor on basophils’ surface is 25 a widely used strategy for the evaluation of IgE-mediated immediate hypersensitivity reactions to 26 drugs. Due to the drug ... -
Nanoscale biocompatible structures generated from fluorinated tripodal phenylenes on gold nanoprisms
García-Castro, Miguel; Moscoso, Ana; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel; Contreras-Cáceres, Rafael; Díaz-Morilla, Amelia[et al.] (Wiley, 2022-03-09)
Modification of gold substrates with a stable, uniform and ultrathin layer of biocompatible materials is of tremendous interest for the development of bio-devices. We present the fabrication of hybrid systems consisting ... -
Electrospun nanofibers: recent applications in drug delivery and cancer therapy
Contreras-Cáceres, Rafael; Cabeza, Laura; Perazzoli, Gloria; Díaz-Morilla, Amelia; López-Romero, Juan Manuel; Melguizo, Consolación; Prados, Jose[et al.] (MDPI, 2019-04)
Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the ... -
Magnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug delivery
García-Pinel, Beatriz; Ortega Rodríguez, Alicia; Porras Alcalá, Cristina; Cabeza, Laura; Contreras-Cáceres, Rafael; Ortiz, Raúl; Díaz-Morilla, Amelia; Moscoso, Ana; Sarabia-García, Francisco Ramón; Prados, Jose; López-Romero, Juan Manuel; Melguizo, Consolación[et al.] (Taylor and Francis, 2020-04-19)
Here, temperature-sensitive hybrid poly(N-isopropylacrylamide) (pNIPAM) nanosystems with magnetic response are synthesised and investigated for controlled release of 5-fluorouracil (5FU) and oxaliplatin (OXA). Initially, ... -
n-Tuples on Scaffold Diversity Inspired by Drug Hybridisation to Enhance Drugability: Application to Cytarabine
García-Castro, Miguel; Fuentes-Ríos, David; López-Romero, Juan Manuel; Romero, Antonio; Moya-Utrera, Federico; Díaz-Morilla, Amelia; Sarabia-García, Francisco Ramón[et al.] (MDPI, 2023-12-13)
A mathematical concept, n-tuples are originally applied to medicinal chemistry, especially with the creation of scaffold diversity inspired by the hybridisation of different commercial drugs with cytarabine, a synthetic ... -
Diastereoselective C-alkylation of aldimines, derived from chiral alpha-carbon heteroatom substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines
Fuentes-Ríos, David; Muñoz, Carmen; Díaz-Morilla, Amelia; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel (Royal Society of Chemistry, 2023-03-13)
The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and distereoisomeric ratios. Stereocontrol is induced ... -
Tripod-shaped molecules: Synthesis and immobilization on Au(1 1 1) substrates.
Sánchez-Molina, María; Díaz-Morilla, Amelia; Sauter, Eric; Zharnikov, Michael; López-Romero, Juan Manuel (2018-11-09)
We describe design and synthesis of novel tripod-shaped molecules that are potentially capable of monomolecular assembly on noble metal substrates, maintaining, due to their rigidity and specific geometry, the orientation ...