Listar QO - Artículos por título
Mostrando ítems 7-26 de 32
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Diastereoselective C-alkylation of aldimines, derived from chiral alpha-carbon heteroatom substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines
Fuentes-Ríos, David; Muñoz, Carmen; Díaz-Morilla, Amelia
; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel (Royal Society of Chemistry, 2023-03-13)
The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and distereoisomeric ratios. Stereocontrol is induced ... -
Dynamic Covalent Properties of a Novel Indolo[3,2-b]carbazole Diradical
Badía-Domínguez, Irene; Peña-Álvarez, Miriam; Wang, Deliang; Pérez Guardiola, Andrés; Vida-Pol, Yolanda; Rodríguez-González, Sandra; López Navarrete, Juan T.; Hernández-Jolín, Víctor; Sancho-García, Juan C.; García-Baonza, Valentín; Nash, Rosie; Hartl, František; Li, Hongxiang; Ruiz-Delgado, María del Carmen[et al.] (Wiley, 2021)
This work describes the synthesis and properties of a dicyanomethylene-substituted indolo[3,2-b]carbazole diradical ICz-CN. This quinoidal system dimerises almost completely to (ICz-CN)2, which contains two long C(sp3)−C(sp3) ... -
Electrospun nanofibers: recent applications in drug delivery and cancer therapy
Contreras-Cáceres, Rafael; Cabeza, Laura; Perazzoli, Gloria; Díaz-Morilla, Amelia; López-Romero, Juan Manuel; Melguizo, Consolación; Prados, Jose[et al.] (MDPI, 2019-04)
Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the ... -
Epi-, epoxy- and C2-modified bengamides: Synthesis and biological Evaluation
Sarabia-García, Francisco Ramón; Martín-Gálvez, Francisca; García-Ruiz, Cristina; Sánchez-Ruiz, Antonio; Vivar García, Carlos (ACS, 2013)
With the objective of investigating the influence of structural modifications of the polyketide chain of the bengamides upon their antitumoral activities, we targeted the preparation of bengamide E analogues with modification ... -
Evaluation of anticancer and anti-inflammatory activities of some synthetic rearranged abietanes
(MDPI, 2023-09-01)Synthesis of the rearranged abietane diterpenes pygmaeocins C and D, viridoquinone, saprorthoquinone, and 1-deoxyviroxocine has been successfully achieved. The anticancer and anti-inflammatory activities of selected ... -
Exploring the chemistry of epoxy amides for the synthesis of the 2"-epi-diazepanone core of liposidomycins and caprazamycins
Sarabia-García, Francisco Ramón; Vivar García, Carlos; García-Ruiz, Cristina; Martín Ortiz, Laura; Romero-Carrasco, Antonio (ACS, 2012)
New synthetic strategies have been explored for the synthesis of the structural core of liposidomycins and caprazamycins, an intriguing class of complex nucleoside-type antibiotics. This structural core is comprised of a ... -
Green synthesis of silver nanoparticles and its combination with Pyropia columbina (Rhodophyta) extracts for a cosmeceutical application
González-Conde, Mercedes; Vega Sánchez, Julia; López-Figueroa, Félix; García-Castro, Miguel; Moscoso, Ana; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel[et al.] (MDPI, 2023-03-10)
We report the green synthesis of silver nanoparticles (AgNPs) by using daisy petals (Bellis perennis), leek (Allium porrum) and garlic skin (Allium sativum) as reducing agents and water as solvent. AgNPs are obtained with ... -
Isolation of Mycosporine-like Amino Acids from Red Macroalgae and a Marine Lichen by High-Performance Countercurrent Chromatography: A Strategy to Obtain Biological UV-Filters.
Vega Sánchez, Julia; Bárcenas-Pérez, Daniela; Fuentes-Ríos, David; López-Romero, Juan Manuel; Hrouzek, Pavel; López-Figueroa, Félix; Cheel, José[et al.] (MDPI, 2023-06-10)
Marine organisms have gained considerable biotechnological interest in recent years due to their wide variety of bioactive compounds with potential applications. Mycosporine-like amino acids (MAAs) are UV-absorbing secondary ... -
Magnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug delivery
García-Pinel, Beatriz; Ortega Rodríguez, Alicia; Porras Alcalá, Cristina; Cabeza, Laura; Contreras-Cáceres, Rafael; Ortiz, Raúl; Díaz-Morilla, Amelia; Moscoso, Ana; Sarabia-García, Francisco Ramón; Prados, Jose; López-Romero, Juan Manuel; Melguizo, Consolación[et al.] (Taylor and Francis, 2020-04-19)
Here, temperature-sensitive hybrid poly(N-isopropylacrylamide) (pNIPAM) nanosystems with magnetic response are synthesised and investigated for controlled release of 5-fluorouracil (5FU) and oxaliplatin (OXA). Initially, ... -
Multiepitope Dendrimeric Antigen-Silica particle composites as nano-based platforms for specific recognition of IgEs
Gil-Ocaña, Violeta; Jimenez, Isabel M.; Mayorga, Cristobalina; Doña, Inmaculada; Cespedes, Jose A.; Montañez, Maria I.; Vida-Pol, Yolanda; Torres, Maria J.; Perez-Inestrosa, Ezequiel[et al.] (Frontiers, 2021)
β-lactam antibiotics (BLs) are the drugs most frequently involved in drug hypersensitivity reactions. However, current in vitro diagnostic tests have limited sensitivity, partly due to a poor understanding of in vivo ... -
n-Tuples on Scaffold Diversity Inspired by Drug Hybridisation to Enhance Drugability: Application to Cytarabine
García-Castro, Miguel; Fuentes-Ríos, David; López-Romero, Juan Manuel; Romero, Antonio; Moya-Utrera, Federico; Díaz-Morilla, Amelia; Sarabia-García, Francisco Ramón[et al.] (MDPI, 2023-12-13)
A mathematical concept, n-tuples are originally applied to medicinal chemistry, especially with the creation of scaffold diversity inspired by the hybridisation of different commercial drugs with cytarabine, a synthetic ... -
NanoFN10: A High-Contrast Turn-On Fluorescence Nanoprobe for Multiphoton Singlet Oxygen Imaging.
Zanocco, Renzo P.; Nájera-Albendín, Francisco; Pérez-Inestrosa, Ezequiel; Zanocco, Antonio L.; Lemp, Else; Nonell-Marrugat, Santiago[et al.] (MDPI, 2023-05-09)
An “off-on” fluorescent nanoprobe for near-infrared multiphoton imaging of singlet oxygen has been developed. The nanoprobe comprises a naphthoxazole fluorescent unit and a singlet-oxygen-sensitive furan derivative attached ... -
Nanoscale biocompatible structures generated from fluorinated tripodal phenylenes on gold nanoprisms
García-Castro, Miguel; Moscoso, Ana; Sarabia-García, Francisco Ramón; López-Romero, Juan Manuel; Contreras-Cáceres, Rafael; Díaz-Morilla, Amelia[et al.] (Wiley, 2022-03-09)
Modification of gold substrates with a stable, uniform and ultrathin layer of biocompatible materials is of tremendous interest for the development of bio-devices. We present the fabrication of hybrid systems consisting ... -
New approaches for Basophil Activation Tests employing Dendrimeric Antigen-Silica Nanoparticle composites.
Calvo-Serrano, Silvia; Matamoros, Esther; Céspedes, José Antonio; Fernández-Santamaría, Rubén; Gil-Ocaña, Violeta; Pérez-Inestrosa, Ezequiel; Frecha, Cecilia; Montañez-Vega, María Isabel; Vida-Pol, Yolanda; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa[et al.] (MDPI, 2024-08-03)
In vitro detection of specific IgE bound to high-affinity receptor on basophils’ surface is 25 a widely used strategy for the evaluation of IgE-mediated immediate hypersensitivity reactions to 26 drugs. Due to the drug ... -
New Insights into Acylhydrazones E/Z isomerization: An Experimental and Theoretical Approach.
Fernández-Palacios, Sara; Matamoros, Esther; Morato Rojas, Isabel; López Navarrete, Juan T.; Ruiz-Delgado, María del Carmen; Vida-Pol, Yolanda; Perez-Inestrosa, Ezequiel[et al.] (MDPI, 2023)
A family of acylhydrazones have been prepared and characterized with the aim of investigating their potential as information storage systems. Their well stablished synthetic methodologies allowed the preparation of seven ... -
Photophysical properties and bioimaging application of an aminonaphthalimide-squaraine non-conjugated system
Stamentović, Vladimir; Collado-Martín, Daniel; Pérez-de-Inestrosa-Villatoro, Ezequiel (ELSEVIER, 2022-02-15)
An aminonaphthalimide-squaraine non-conjugated system was designed and synthetized with the purpose of preparing fluorescent molecule in the 650–700 nm region that could operate via energy transfer (ET) between covalently ... -
Slightly congested amino terminal dendrimers. The synthesis of amide-based stable structures on a large scale.
Morgado Benítez, Anjara; Nájera-Albendín, Francisco; Lagunas, Anna; Samitier, Josep; Vida-Pol, Yolanda; Pérez-de-Inestrosa-Villatoro, Ezequiel[et al.] (Royal Society of Chemistry, 2021-08-17)
Nowadays, amino terminal dendrimers are appealing materials for biological applications due to their multivalence and the versatile conjugation of the amino groups. However, the high reactivity of these terminal groups can ... -
Solid phase synthesis of globomycin and SF-1902 A5
The syntheses of the natural lipocyclodepsipeptide-type antibiotics globomycin and SF-1902 A5 are reported utilizing solid phase technology for the construction of the peptidic fragment and a new asymmetric methodology of ... -
SPION Nanoparticles for Delivery of Dopaminergic Isoquinoline and Benzazepine Derivatives.
Lucena-Serrano, Cristina; Lucena-Serrano, Ana; Díaz-Morilla, Amelia; Valpuesta-Fernández, María; Villaverde, Gonzalo; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón; Laurenti, Marco; Rubio Retama, Jorge; Contreras-Cáceres, Rafael[et al.] (Elsevier, 2022-06-27)
Superparamagnetic iron nanoparticles (SPIONs) have become one of the most useful colloidal systems in nanomedicine. We report here the preparation of new hybrid core@shell systems based on SPION nanoparticles coated with ... -
Stereoselective total synthesis of (-)-Depudecin
The total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported. Characterized by a highly oxidized 11-carbon chain containing ...