Listar QO - Artículos por título
Mostrando ítems 1-20 de 51
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A Turn-On Two-Photon Fluorescent Probe for Detecting Lysosomal Hydroxyl Radicals in Living Cells.
(Elsevier, 2019)The detection of reactive oxygen species (ROS) in biological systems and its imaging is of great importance. Among them, the hydroxyl radical (radical dotOH) stands out as one of the most reactive, playing an important ... -
Amoxicillin Haptenation of Alpha-Enolase is Modulated by Active Site Occupancy and Acetylation.
(Frontiers, 2022)Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the ... -
An array of bengamide E analogues modified at the terminal olefinic position: Synthesis and antimor properties.
(Chemistry Europe · European Chemical Societies Publishing, 2013-03-19)Based on our previously described synthetic strategy for bengamide E, a natural product of marine origin with antitumor activity, a small library of analogues modified at the terminal olefinic position was generated with ... -
An olefin cross-metathesis approach to depudecin and stereoisomeric analogues
(ACS, 2017)A new total synthesis of the natural product (−)-depudecin, a unique and unexplored histone deacetylase (HDAC) inhibitor, is reported. A key feature of the synthesis is the utilization of an olefin cross-metathesis strategy, ... -
An olefin metathesis approach towards the solomonamides.
(Elsevier, 2016)A new synthetic strategy directed towards the solomonamides, a novel class of cyclopeptides of marine origin, has been developed utilizing an olefin metathesis reaction to form the [15]-membered ring contained in these ... -
Bengamide Analogues Show a Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study
(2020-05-02)The limited success and side effects of the current chemotherapeutic strategies against colorectal cancer (CRC), the third most common cancer worldwide, demand an assay with new drugs. The prominent antitumor activities ... -
Benzotriazole-based multidonor-acceptor systems as attractive two-photon absorption dye platforms
(Elsevier, 2022-02-03)Pyrazine-decorated benzotriazole cores allow the orthogonal combination of two dipolar systems within a single molecule. A series of this type of derivatives was synthesized and their photophysical features were studied. ... -
Catalyzed Methods to Synthesize Pyrimidine and Related Heterocyclic Compounds
(MDPI, 2023-01-12)This review covers articles published in the period from 2010 to mid-2022 on synthetic advances in the formation of pyrimidine and related heterocyclic compounds. Special emphasis has been given to the different types ... -
Chemistry and biology of bengamides and bengazoles, bioactive natural products from Jaspis sponges
(MDPI, 2014)Sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the bengamides and the bengazoles stand out by virtue of their unprecedented molecular architectures ... -
Diastereoselective C-alkylation of aldimines, derived from chiral alpha-carbon heteroatom substituted aldehydes, with triethylborane. Application to the synthesis of benzylisoquinolines
(Royal Society of Chemistry, 2023-03-13)The one-pot reaction of a chiral aldehyde, p-methoxyaniline or p-fluoroaniline, and triethylborane produces the corresponding alkylated chiral amine with high yields and distereoisomeric ratios. Stereocontrol is induced ... -
Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes
(ACS, 2023-05-30)An asymmetric three-component carbosulfonylation of alkenes is presented here. The reaction, involving the simultaneous formation of a C–C and a C–S bond across the π-system, uses a dual nickel/photoredox catalytic system ... -
Dynamic Covalent Properties of a Novel Indolo[3,2-b]carbazole Diradical
(Wiley, 2021)This work describes the synthesis and properties of a dicyanomethylene-substituted indolo[3,2-b]carbazole diradical ICz-CN. This quinoidal system dimerises almost completely to (ICz-CN)2, which contains two long C(sp3)−C(sp3) ... -
Electrospun nanofibers: recent applications in drug delivery and cancer therapy
(MDPI, 2019-04)Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the ... -
Energy-Transfer Sensitization of BODIPY Fluorescence in a Dyad with a Two-Photon Absorbing Antenna Chromophore
(Elsevier, 2023)A bichromophoric dyad composed of a Prodan-derived moiety and a BODIPY dye was prepared, photophysically characterized, and tested for multiphoton fluorescence microscopy of N13 microglial cells. The dyad shows highly ... -
Epi-, epoxy- and C2-modified bengamides: Synthesis and biological Evaluation
(ACS, 2013)With the objective of investigating the influence of structural modifications of the polyketide chain of the bengamides upon their antitumoral activities, we targeted the preparation of bengamide E analogues with modification ... -
Evaluation of anticancer and anti-inflammatory activities of some synthetic rearranged abietanes
(MDPI, 2023-09-01)Synthesis of the rearranged abietane diterpenes pygmaeocins C and D, viridoquinone, saprorthoquinone, and 1-deoxyviroxocine has been successfully achieved. The anticancer and anti-inflammatory activities of selected ... -
Exploring the Antiangiogenic Potential of Solomonamide A Bioactive Precursors: In Vitro and In Vivo Evidences of the Inhibitory Activity of Solo F-OH During Angiogenesis
(2019-04-15)Marine sponges are a prolific source of bioactive compounds. In this work, the putative antiangiogenic potential of a series of synthetic precursors of Solomonamide A, a cyclic peptide isolated from a marine sponge, was ... -
Exploring the chemistry of epoxy amides for the synthesis of the 2"-epi-diazepanone core of liposidomycins and caprazamycins
(ACS, 2012)New synthetic strategies have been explored for the synthesis of the structural core of liposidomycins and caprazamycins, an intriguing class of complex nucleoside-type antibiotics. This structural core is comprised of a ... -
Exploring the reactivity of chiral glycidic amides for their applications in synthesis of bioactive compounds.
(Wiley, 2014-05)A new class of chiral sulfonium salts, derived from L- and D-methionine, has been designed and successfully employed in our laboratories for the diastereoselective synthesis of glycidic amides. The epoxy amides obtained ... -
Extended Alkenyl and Alkynyl Benzotriazoles with enhanced Two‐Photon Absorption properties as a promising alternative to Benzothiadiazoles
(Wiley-VCH Verlag GmbH & Co, 2019)A series of donor–p–acceptor–p–donor (D-p-A-p-D) benzoazole dyes with 2H-benzo[d][1,2,3]triazole or BTDcores have been prepared and their photophysical proper-ties characterized. The properties of these compounds dis-play ...