Listar FHEFD - Contribuciones a congresos científicos por título
Mostrando ítems 49-68 de 134
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GAL(1-15) induces a depression and anxiogenic effect trough GALR1/GALR2 heteroreceptor: siRNA GALR1/GALR2 knockdown rats
Millón-Peñuela, Carmelo
; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Parrado-Romero, Concepción; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2015-10-06)
The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic- like actions. In this work, we have studied the role of GALR2 and GALR1 on the effects of GAL(1-15) in the Forced Swimming Test (FST) ... -
Galanin (1-15) and escitalopram combination in rats reduces alcohol consumption in the ethanol self-administration test and improves escitalopram effects in the forced swimming test.
Cantero-García, Noelia; Flores-Burgess, Antonio; Ladrón de Guevara-Miranda, David; Serrano, Antonia; García-Durán, Laura; Puigcerver-Martínez, Araceli; Fuxe, Kjell; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2022-07-12)
Recently, we described that Galanin(1-15)[GAL(1-15)] enhanced Escitalopram(ESC) effectiveness in depression symptoms. Moreover GAL(1-15) induces a substantial reduction in alcohol consumption. To investigate the effect of ... -
Galanin (1-15) enhances the behavioral effects of fluoxetine in the forced swimming test: a new therapeutic strategy against depression
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Gago-Calderón, Belén; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2017)
The selective serotonergic (5- HT) reuptake inhibitors, including Fluoxetine (FLX), are the most commonly used for treatment of major depression. However, the understanding of the mechanism of action of FLX beyond its ... -
Galanin (1-15) enhances the behavioural effects of escitalopram in the forced swimming test in rats
García-Durán, Laura; Cantero-García, Noelia; Flores-Burgess, Antonio; Gago-Calderón, Belén; Puigcerver-Martínez, Araceli; Narváez-Bueno, José Ángel; Santín-Núñez, Luis Javier; Millón-Peñuela, Carmelo; Díaz-Cabiale, Zaida[et al.] (2021-01-22)
The selective serotonergic reuptake inhibitors (SSRIs) are the most commonly used for the treatment of major depression. Recently, we observed that the Galanin N-terminal fragment (1-15) [GAL(1-15)] enhances the ... -
Galanin (1-15) enhances the effects of Fluoxetine in an animal model of depression. Role of the 5-HT1A receptor.
Pineda-Gómez, Juan Pedro; Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Cantero-García, Noelia; Flores Gómez, Marta; Puigcerver-Martínez, Araceli; Díaz-Cabiale, Zaida[et al.] (2023)
Major depression is one of the most significant contributors to global disability. Selective serotoninergicreuptake inhibitors, including Fluoxetine (FLX), are the most commonly used antidepressant but are onlyeffective ... -
Galanin (1-15) increased the neuropétide-Y Y1 receptor bindng in the amygdala of the rats
Flores-Burgess, Antonio; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Narváez-Bueno, José Ángel (2014-09-30)
Galanin (GAL) and N-terminal Galanin fragment (1-15) [GAL(1-15)] interact at membrane level with Neuropeptide Y receptors. In the nucleus of the solitary tract GAL modified the cardiovascular action of the NPYY1 and GAL(1-15) ... -
Galanin and galanin fragment 1-15 modulate antidepressant responses by targeting 5-HT1AR-GALR heteroreceptor complexes of the ascending midbrain serotonin pathways.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (Cinp, 2016-07-03)
Mood disorders, including depression and anxiety, are among the most prevalent mental illnesses with high socioeconomic impact. Although the underlying mechanisms have not yet been clearly defined in the last decade the ... -
Galanin and Neuropeptide Y Interaction Enhances Proliferation of Granule Precursor Cells and Expression of Neuroprotective Factors in the Rat Hippocampus: Role in depression and memory
Mirchandani-Duque, Marina; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Álvarez-Contino, José Erik; García-Casares, Natalia; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar; Narváez-Peláez, Manuel[et al.] (2022-09-22)
Neuropeptide Y(NPY) Y1 receptor (Y1R) and galanin (GAL) receptor 2 (GALR2) interact in brain regions responsible for mood control and learning and memory processes, emphasizing the hippocampus. The current study assesses ... -
Galanin and Neuropeptide Y interaction leads to antidepressant effects through hippocampal cell proliferation.
Narváez-Peláez, Manuel; Fores-Pons, Ramón; Pita-Rodríguez, Mariana; Fuxe, Kjell; Borroto Escuela, Dasiel Óscar (2020-09-01)
Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation, through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers. ... -
Galanin and neuropeptide Y interactions linked to neuronal precursor cells of the dentate gyrus in the hippocampus. Role in depression and cognitive impairment.
Fores-Pons, Ramón; Borroto Escuela, Dasiel Óscar; Pita-Rodríguez, Mariana; Barbancho-Fernández, Miguel Ángel; López-Salas, Alexander; Rosas-Marqués, Paloma; Zamorano-González, Pablo; Fuxe, Kjell; García-Casares, Natalia; Narváez-Peláez, Manuel[et al.] (2021-11-05)
Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation, through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers. ... -
Galanin and neuropeptide y Y1 receptor agonist coinjection increases newborn cells proliferation on hippocampal dentate gyrus in rats
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Fuxe, Kjell (2018-07-13)
The hippocampus is a region in which neurogenesis persists throughout the lifespan in a wide variety of species including humans. Within the dentate gyrus of the hippocampus, the subgranular zone (SGZ) is maintained as a ... -
Galanin decreases NPYY1R internalization and β- Arrestin2 recruitment
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-05)
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ... -
Galanin interacts with Neuropeptide Y Y1 receptor in the dentate gyrus of the hippocampus through GALR2/NPYY1R heterodimers
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2016-07-11)
We have shown Galanin(GAL) and Neuropeptide Y Y1(NPYY1) interactions at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers in the amygdala. The aim of this work was to analyze GAL/NPYY1R interactions ... -
Galanin n-terminal fragment (1-15) decreases the voluntary alcohol intake in rats
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Castilla-Ortega, María Estela; Gago-Calderón, Belén; Serrano, Antonia; Sturla, Antonella; García-Durán, Laura; Narváez-Bueno, José Ángel; Fuxe, Kjell; Santín-Núñez, Luis Javier; Díaz-Cabiale, Zaida[et al.] (2018-06-28)
Galanin (GAL) is involved in drug abuse and addiction including alcohol intake. In this work, we have analysed the role of the N-terminal GAL fragment (1-15) [GAL(1-15)] in voluntary ethanol consumption in rats using the ... -
Galanin N-Terminal fragment (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT in the Forced Swimming Test.
Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Santín-Núñez, Luis Javier; Gago-Calderón, Belén; Parrado-Romero, Concepción; Gomez de Travecedo, Isabel; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2016-07-27)
Galanin and Galanin (1-15) [GAL(1-15)] are implicated in anxiety- and depression related behaviors. Moreover, Galanin modulates 5-HT1A receptor (5-HT1AR) function at autorreceptor and postsynaptic level in the brain. In ... -
Galanin N-Terminal fragment (1-15) induces a stronger effect than Galanin in depression- and anxiety- like related behavioural tests in rats.
Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Flores-Burgess, Antonio; Parrado-Romero, Concepción; Puigcerver-Martínez, Araceli; Coveñas, Rafael; Santín-Núñez, Luis Javier; Borroto Escuela, Dasiel Óscar; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2014-07-16)
Galanin (GAL) and GAL Receptors are implicated in anxiety- and depression- related behaviours. The GAL N-terminal fragment (1-15) [GAL(1-15)] also induces depressant- and anxiogenic- like actions. In this work, we have ... -
Galanin n-terminal fragment (1-15) induces an anxiety- and depressive-like behaviours in the light/dark and tail suspension tests
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Santín-Núñez, Luis Javier; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-21)
Galanin N-terminal fragment (1-15) [Gal(1-15)] is involved in mood regulation. We have shown that intracerebroventricular (icv) administration of Gal(1-15) produces a depressive-like behaviour in the forced swim test (FST) ... -
Galanin N-terminal fragment (1-15) reduces alcohol consumption in the self-administration with involvement of mesocorticolimbic system in rats.
Cantero-García, Noelia; Flores Gómez, Marta; Flores-Burgess, Antonio; Pineda-Gómez, Juan Pedro; Orio, Laura; Serrano, Antonia; Díaz-Cabiale, Zaida; Millón-Peñuela, Carmelo[et al.] (2023)
Alcohol Use Disorder (AUD) is a highly prevalent disorder characterized by an impaired ability tostop or control alcohol use despite the adverse consequences. Nowadays, AUD treatment is limiteddue to the low efficacy of ... -
Galanin n-terminal gragment (1-15) modifies the 5-HT1A receptor against [H3]-8-OH-DPAT binding in the dorsal raphe and hippocampus of the rat
Flores-Burgess, Antonio; Millón-Peñuela, Carmelo; Narváez-Peláez, Manuel; Barroto-Escuela, Dasiel; Santín-Núñez, Luis Javier; Gago-Calderón, Belén; Gomez de Travecedo, Isabel; Narváez-Bueno, José Ángel; Fuxe, Kjell; Díaz-Cabiale, Zaida[et al.] (2016-09-09)
We have described that Galanin N-terminal fragment (1-15) [GAL(1-15)] is associated with depressive effects and also modulates the antidepressant effects induced by the 5-HT1A receptor (5-HT1AR) agonist 8-OH-DPAT. The aim ... -
Galanin receptor 2 modifies neuropeptide Y Y1 receptor internalization and β-Arrestin recruitment
Narváez-Peláez, Manuel; Borroto Escuela, Dasiel Óscar; Millón-Peñuela, Carmelo; Flores-Burgess, Antonio; Gago-Calderón, Belén; Santín-Núñez, Luis Javier; Fuxe, Kjell; Narváez-Bueno, José Ángel; Díaz-Cabiale, Zaida[et al.] (2015-10-05)
We have recently described a Galanin receptor 2(GALR2) and Neuropeptide Y Y1 receptor(NPYY1R) interaction at behavioural, cellular and receptor levels through GALR2/NPYY1R heterodimers. The aim of this work was to study ...