BCGF - Contribuciones a congresos científicos
Envíos recientes
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DEPTOR promotes bone marrow adipose tissue expansion in calorie restricted mice.
Elevated levels of fat in bones is a characteristic feature of osteoporosis and other skeletal disorders. While the molecular mechanism behind this shift between bone and fat formation remains incompletely understood, it ... -
Cognitive decline and tau-associated pathology worsen after late-life depression in P301S mice.
Vegas-Gómez, Laura; Gutiérrez-Sastre, Cristina; Arredondo-Alcalá, María Ángeles; Gutiérrez-Pérez, Antonia
; Moreno-González, Inés (2024)
Recent studies suggest that depression may be a crucial risk factor for the development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life depression and AD. ... -
Female microglia and neurogenesis respond differently to social defeat stress compared to males.
Infantes-López, María Inmaculada; Zambrana-Infantes, Emma; Chaves-Peña, Patricia; Nieto-Quero, Andrea; Muñoz-Martín, José; Zea-Doña, Alejandro; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (2024)
Depression is a concerning public health threat highly associated with stress. Stress increases brain immune alterations, namely in microglia, which can affect neuron physiology, like neurogenesis, causing a depressive-like ... -
Comparación funcional de los secretomas de Pseudomonas savastanoi pv. savastanoi NCPPB 3335 y P. savastanoi pv. phaseolicola 1448a: identificando estrategias de virulencia y mecanismos de interacción con el huésped.
Domínguez-Cerván, Hilario; Díaz-Martínez, Luis; Ramos-Rodríguez, Cayo Juan; Rodríguez-Moreno, Luis Gabriel (2024-06-17)
La bacteria fitopatógena Pseudomonas savastanoi es el agente causal de enfermedades en huéspedes leñosos y herbáceos de interés agronómico y ornamental. La especie P. savastanoi engloba 7 patovares denominados según el ... -
Hippocampal neurogenesis changes in a sex and region-specific manner in adult mice subjected to maternal separation as an early life stress.
Muñoz-Martín, José; Chaves-Peña, Patricia; Infantes-López, María Inmaculada; Zambrana-Infantes, Emma; Nieto-Quero, Andrea; Carayol-Gordillo, Virginia; Martín-Aguiar, Víctor; Zea-Doña, Alejandro; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (2024)
Introduction: Early life stress (ELS) might produce long lasting changes in hippocampal neurogenesis and increase the vulnerability to stress-related disorders later in adulthood. Objective: The analysis of immature granule ... -
Nodavirus-host interplay: what we know and what is next.
Moreno, Patricia; Álvarez-Torres, Daniel; García-Rosado, Esther; Alonso-Sánchez, María del Carmen; Béjar-Alvarado, Julia (2024)
Nervous necrosis virus (NNV) is a bisegmented ssRNA virus that is classified into four species: SJNNV, RGNNV, TPNNV and BFNNV. NNV causes viral nervous necrosis, a disease that affects farmed fish worldwide and in the ... -
Study of the impact of m6A RNA methylation in altered molecular mechanisms in colorectal cancer and its association with obesity
(2023-12-01)Although the etiology of colorectal cancer (CRC) is multifactorial and complex, due to the interaction of altered environmental and genetic mechanisms, obesity is considered a crucial risk factor in the initiation and ... -
Alteraciones del perfil epitranscriptómico (m6A) asociadas a mecanismos biológicos del cáncer colorrectal y obesidad.
(2023-11-24)La obesidad considerada un factor de riesgo crucial en el inicio y progresión del cáncer colorrectal, podría promover un microentorno favorable a la carcinogénesis mediado por alteraciones epitranscriptómicas, como la ... -
Bone organoid generation based on double scaffolding.
Decellularized bone matrix ( is a classic approach in bone tissue engineering based on the removal of bone tissue cells and the calcified phase using chemical, physical o enzymatic agents The resulting matrix preserves ... -
Validation of two pmx-luciferase reporter systems to study virus - host interaction.
Béjar-Alvarado, Julia; Álvarez-Torres, Daniel; Alonso-Sánchez, María del Carmen; García-Rosado, Esther (2023)
Viral diseases represent an important threat in aquaculture. Therefore, the development of strategies and tools to understand fish susceptibility, virus-host interaction, or to identify viral virulence markers is a priority. ... -
Phenotypically heterogeneous loci in the plant pathogen Pseudomonas syringae.
Mancera-Miranda, Laura; López-Pagán, Nieves; Rufián Plaza, José Sebastián; Sánchez-Romero, María Antonia; Gutierrez-Pozo, Gabriel; Spröer, Cathrin; Bunk, Boyke; Ruiz-Albert, Francisco Javier; Beuzón-López, Carmen del Rosario[et al.] (2023)
Phenotypic heterogeneity usually refers to the co-existance of different phenotypes within a population. Phenotypic differences may arise through genetic variation (genomic rearrangements or mutations) or through the ... -
Implementación de una Gymkhana molecular.
García Luque, Estefanía; Ortiz-Martín, Inmaculada; Del Espino Pérez, Ángel; Viguera-Mínguez, Enrique (Asociación Española de Comunicación Científica, 2023)
El gran desarrollo de las técnicas de biología molecular de alto rendimiento y la consiguiente generación de datos de secuencias de ADN requiere la capacitación del alumnado, de forma que la asignatura de Bioinformática o ... -
Role of chemotaxis cluster II in pathogenic bacteria of woody and herbaceous plants.
Lavado-Benito, Carla; Rodríguez-Moreno, Luis Gabriel; Santamaría-Hernando, Saray; López-Solanilla, Emilia; Ramos-Rodríguez, Cayo Juan (International Society for plant pathology, 2023)
Chemoreceptors are essential proteins able to detect environmental changes for bacterial adaptation to the environment. The genes encoding these proteins are found individually in the genome or forming clusters with other ... -
Multiciliated ependyma recovery through a sequential cell therapy in posthemorrhagic hydrocephalus.
López-de-San-Sebastián, Javier; Rodríguez-Pérez, Luis Manuel; González-García, Marcos; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús (2023)
Posthemorrhagic hydrocephalus (PHH) is a significant cause for premature children’s morbidity, mortality, and peri/postnatal neurodevelopmental impairment. PHH is mainly triggered by germinal matrix hemorrhages (GMH) and ... -
Monocyte-derived cells invade amyloid plaques in human alzheimer’s disease hippocampus.
Mejías-Ortega, Marina; Muñoz-Castro, Clara; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Microglia, the brain-resident myeloid cells, play a major role in the immune responses of the nervous system and in the pathogenesis of Alzheimer's disease (AD). However, the presence of peripheral myeloid cells in the AD ... -
Late-life depression accelerates cognitive decline in a tauopathy mouse model
Vegas-Gómez, Laura; Fernández-Valenzuela, Juan José; Gutiérrez-Pérez, Antonia; Moreno-González, Inés (IBRO/FENS, 2023)
Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Sexual differences in hippocampal microglia of adult mice subjected to maternal separation stress.
Muñoz-Martín, José; Infantes-López, M. Inmaculada; Chaves-Peña, Patricia; Nieto-Quero, Andrea; Zambrana-Infantes, Emma; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (IBRO Congress 2023, 2023)
Introduction: It is well known that early life adversities could a"ect brain development and increase the vulnerability to stress-related disorders later in adulthood. Nevertheless, the neurobiological mechanisms underlying ... -
Gut microbiome specific changes in different behavioral profiles in a mouse social defeat stress model.
Infantes-López, M. Inmaculada; Domínguez-Maqueda, Marta; Cerezo Ortega, Isabel M.; Zambrana-Infantes, Emma; Moriñigo-Gutiérrez, Miguel Ángel; Pedraza-Benítez, María del Carmen; Pérez-Martín, Margarita[et al.] (2023)
The gut microbiome has arisen as one important modulator of general health, including brain function. In fact, disturbances in brain health are commonly mirrored in the microbiome, which could be contributing to pathology. ... -
Mitochondrial ultrastructural defects in reactive astrocytes of Alzheimer's mice hippocampus.
Trujillo-Estrada, Laura Isabel; López Oliva, Elba; Fernández-Valenzuela, Juan José; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Vizuete, María Luisa; Vitorica Ferrández, Javier; Gutiérrez-Pérez, Antonia[et al.] (2023)
Alzheimer's disease (AD) is a complex neurodegenerative condition that causes progressive memory loss and dementia. In AD brains astrocyte become reactive potentially contributing to cognitive decline. Astrocyte reactivity ... -
Partial inhibition of CSF1R signaling reverses long-term microglial priming.
Microglial cells are main actors in acute neuroinflammation, during which they activate to later return to a basal resting state. Sometimes they retain immune memory of previous neuroinflammatory events, turning into ...