Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss in
obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, which is present in adipocytes
and the stromal vascular fraction of human adipose tissue (AT), is up-regulated in AT of insulin-resistant morbidly obese subjects
compared with healthy lean subjects. The aim of this study was to explore the effects of in vitro and in vivo administration of GLP-1
and its analogues on AT and adipocyte functions from T2D morbidly obese subjects.
; Delgado-Lista, Javier; Díaz-Ruiz, Alberto; Guzmán-Ruiz, Rocio; Vázquez-Martínez, Rafael; Lhamyani, Said; Roca-Rodríguez, María del Mar; Fernández-Veledo, Sonia; Vendrell, Joan; Malagón, Maria M.; Tinahones-Madueño, Francisco José
