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dc.contributor.authorLabella Vera, Alejandro Manuel
dc.contributor.authorGémez Mata, Juan
dc.contributor.authorVera, Isabel
dc.contributor.authorBandin, Isabel
dc.contributor.authorLeiva Rebollo, Rocío
dc.contributor.authorBorrego-García, Juan José
dc.contributor.authorGarcía-Rosado, Esther 
dc.date.accessioned2024-10-10T08:42:05Z
dc.date.available2024-10-10T08:42:05Z
dc.date.issued2019
dc.identifier.citationA. Labella, J. Gémez, I. Vera, I. Bandín, R. Leiva, J.J. Borrego, E. Garcia-Rosado, Analysis of gene expression in nodavirus-inoculated Senegalese sole using a new Openarray® platform, Fish & Shellfish Immunology, Volume 91, 2019, Pages 391-392, ISSN 1050-4648, https://doi.org/10.1016/j.fsi.2019.04.077. (https://www.sciencedirect.com/science/article/pii/S1050464819303158)es_ES
dc.identifier.urihttps://hdl.handle.net/10630/34600
dc.description.abstractNervous necrosis virus (NNV) is the causative agent of the viral encephalopathy and retinopathy, a disease that affects cultured Senegalese sole (Solea senegalensis). A NNV reassortant (Ss160.03), combining genomic segments from red-spotted grouper nervous necrosis virus (RGNNV) and striped jack nervous necrosis virus (SJNNV) genotypes, has been previously isolated from Senegalese sole, being highly virulent to this fish species. The RNA-Seq technology has been used in a previous study to comparatively analyse Senegalese sole transcriptomes in two organs (head kidney and eye/brain) after infection with two NNV virus with different levels of virulence to that fish species, a highly virulent reassortant isolate (wSs160.03) and a less virulent mutant reassortant obtained by reverse genetics (rSs160.03247þ270). To validate previous RNA-Seq results, a 112- assay OpenArray® platform (Thermofisher) has been designed. This platform included 89 genes chosen according to transcriptomic changes observed by RNA-Seq (covering PRRs, type I IFN response, signal transduction, inflammation, virus responsive genes, and apoptosis), 17 genes selected based on their previously described relation with the immune response against fish viral infections, and 6 control genes (including 3 endogenous genes and 3 viral genes).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPeces - Agentes patógenoses_ES
dc.subject.otherSolea senegalensises_ES
dc.subject.otherReassortant nervous necrosis viruses_ES
dc.subject.otherDifferentially expressed geneses_ES
dc.subject.otherImmune responsees_ES
dc.subject.otherOpen-arrayes_ES
dc.titleAnalysis of gene expression in nodavirus-inoculated Senegalese sole using a new Openarray® platform.es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleInternational Conference on Fish and Shellfish Immunologyes_ES
dc.relation.eventplaceLas Palmas de Gran Canaria, Españaes_ES
dc.relation.eventdate16/06/2019es_ES
dc.identifier.doi10.1016/j.fsi.2019.04.077
dc.rights.ccAtribución 4.0 Internacional*


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