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Stereoselective total synthesis of (-)-Depudecin

dc.contributor.authorGarcía-Ruiz, Cristina
dc.contributor.authorCheng-Sánchez, Iván
dc.contributor.authorSarabia-García, Francisco Ramón 
dc.date.accessioned2024-10-10T08:09:28Z
dc.date.available2024-10-10T08:09:28Z
dc.date.created2024
dc.date.issued2015
dc.identifier.citationGarcía-Ruiz, C.; Cheng-Sánchez, I.; Sarabia, F. Stereoselective total synthesis of (-)-depudecin. Org. Lett. 2015, 17, 22, 5558-5561 ttps://doi.org/10.1021/acs.orglett.5b02697es_ES
dc.identifier.urihttps://hdl.handle.net/10630/34596
dc.description.abstractThe total synthesis of the natural product depudecin, an antiangiogenic microbial polyketide with inhibitory activity against histone deacetylases, is reported. Characterized by a highly oxidized 11-carbon chain containing two epoxides conjugated through a trans-disubstituted olefin, its total synthesis was efficiently accomplished by a novel asymmetric methodology of epoxide formation based on a new class of chiral sulfonium salts, allowing for the construction of the oxirane rings in an efficient and stereoselective fashion.es_ES
dc.description.sponsorshipThis work was financially supported by the Ministerio de Economı́a y Competitividad (MINECO) (CTQ2014-60223-R). C.G.-R. thanks the Ministerio de Educación y Ciencia and Research Plan of the University of Málaga (UMA-RP) for predoctoral and postdoctoral fellowships, respectively. I.C.-S. thanks the University of Málaga (Plan Propio-Programa de Iniciación a la Investigación 2014) and Ministerio de Educación, Cultura y Deporte (Programa FPU) for predoctoral fellowships, respectively. We thank Dr. J. I. Trujillo from Pfizer (Groton, CT) for assistance in the preparation of this manuscript. we thank the Unidad de Espectroscopı́a de Masas and the NMR facility of the University of Málaga for exact mass and NMR spectroscopic assistance. This work has been awarded a “XVII Young Researchers - Esteve Award” funded by SEQT.es_ES
dc.language.isoenges_ES
dc.publisherACSes_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPolímeroses_ES
dc.subject.otheralcoholses_ES
dc.subject.otheraldehydeses_ES
dc.subject.otheramideses_ES
dc.subject.otherorganic polymerses_ES
dc.subject.otherpeptides and proteinses_ES
dc.titleStereoselective total synthesis of (-)-Depudecines_ES
dc.typejournal articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doi10.1021/acs.orglett.5b02697
dc.type.hasVersionSMURes_ES
dc.departamentoQuímica Orgánica
dc.rights.accessRightsopen accesses_ES


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