Background: Patients with chronic kidney disease (CKD) have a high symptoms burden that is related to a poor
health-related quality of life (HRQoL) and high costs of care. Validated instruments may be useful for assessing the
symptoms and monitoring outcomes in these patients. The Palliative care Outcome Scale-Symptoms Renal (POS-S
Renal) is a patient-reported outcome measure for assessing symptoms in CKD stage 4–5. This study is the first
cross-cultural adaptation and psychometric analysis of this clinical tool. The purpose of this study is to carry out a
cross-cultural adaptation of the POS-S Renal for Spanish-speaking patients, and to perform an analysis of the
psychometric properties of this questionnaire.
Methods: The English version of the POS-S Renal was culturally adapted and translated into Spanish using a double
forward and backward method. An expert panel evaluated the content validity. The questionnaire was pilot-tested in
30 patients. A total of 200 patients with CKD stage 4–5 filled in a modified Spanish version of the POS-S Renal and the
MSAS-SF. Statistical analysis to evaluate the psychometric properties of the questionnaire was carried out.
