The Cognitive Emotion Regulation Questionnaire (CERQ) is an instrument developed to assess the cognitive strategies of emotional regulation used by people after experiencing a negative event. The present study aimed to validate the Spanish version of the CERQ in students of the University of Granada (Spain) during the Covid-19 homebound. An online scale was developed and applied based on the Spanish version of the CERQ-S36, consisting of 36 items structured around nine cognitive strategies. Using a mixed sampling, the scale was applied to 450 students from different degree programmes. Regarding the psychometric results of the scale, firstly, in relation to reliability as internal consistency, we found that the scale applied to University students in a Covid-19 setting is highly stable. Secondly, in reference to concurrent criterion validity, we can conclude that the items individually measure the same as the total scale (taken as internal criterion), and thirdly and finally, in relation to construct validation, the two factor analyses implemented, one exploratory and the other confirmatory in nature, conform a factor structure of latent dimensions identical to the original one. In conclusion, the results obtained as a whole suggest that the CERQ-S36 scale could be useful for assessing cognitive coping in University populations in times of crisis. In situations such as the current global emergency due to the presence of Covid-19, the scale is useful for understanding emotional regulation strategies. More studies should be carried out with this scale to find out how emotions influence and what consequences they have on the health and psychological functioning of University students in times of social crisis.