Detection methods predict differences in biology and survival in breast cancer patients
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Autor
Redondo-Bautista, Maximino; Funez, Rafael; Medina Cano, Francisco José; Rodrigo, Isabel; Acebal-Blanco, María Mercedes
; Téllez-Santana, Teresa
; Roldán Cardenete, María José; Hortas Nieto, María Luisa; Bellinvia, Ana; Pereda, Teresa; Domingo, Laia; Morales-Suárez-Varela, María Manuela; Sala, Maria; Rueda-Domínguez, Antonio
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Fecha
2012 -
Editorial/Editor
BMC Springer Nature -
Palabras clave
Mamas - Cáncer -
Resumen
Background: The aim of this study was to measure the biological characteristics involved in tumorigenesis and the progression of breast cancer in symptomatic and screen-detected carcinomas to identify possible differences. Methods: For this purpose, we evaluated clinical-pathological parameters and proliferative and apoptotic activities in a series of 130 symptomatic and 161 screen-detected tumors. Results: After adjustment for the smaller size of the screen-detected carcinomas compared with symptomatic cancers, those detected in the screening program presented longer disease-free survival (RR = 0.43, CI = 0.19-0.96) and had high estrogen and progesterone receptor concentrations more often than did symptomatic cancers (OR = 3.38, CI = 1.72-6.63 and OR = 3.44, CI = 1.94-6.10, respectively). Furthermore, the expression of bcl-2, a marker of good prognosis in breast cancer, was higher and HER2/neu expression was lower in screen-detected cancers than in symptomatic cancers (OR = 1.77, CI = 1.01-3.23 and OR = 0.64, CI = 0.40-0.98, respectively). However, when comparing prevalent vs incident screen-detected carcinomas, prevalent tumors were larger (OR = 2.84, CI = 1.05-7.69), were less likely to be HER2/neu positive (OR = 0.22, CI = 0.08-0.61) and presented lower Ki67 expression (OR = 0.36, CI = 0.17-0.77). In addition, incident tumors presented a shorter survival time than did prevalent ones (RR = 4.88, CI = 1.12-21.19). Conclusions: Incident carcinomas include a variety of screen-detected carcinomas that exhibit differences in biology and prognosis relative to prevalent carcinomas. The detection method is important and should be taken into account when making therapy decisions. -
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