Tumor immune escape by autotaxin: keeping eosinophils at bay
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Fecha
2024-04 -
Editorial/Editor
Elsevier -
Palabras clave
Cáncer -
Resumen
Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid mediator lysophosphatidic acid (LPA). In a recent Nature Cancer paper, Bhattacharyya et al. show that ATX/LPA signaling suppresses CCL11-driven infiltration of eosinophils into the pancreatic tumor microenvironment to facilitate tumor progression, thus revealing a new ATX-mediated immune escape mechanism and highlighting the antitumor potential of eosinophils -