Probabilistic Tsunami Hazard Analysis (PTHA) quantifies the probability of exceeding a
specified inundation intensity at a given location within a given time interval. PTHA
provides scientific guidance for tsunami risk analysis and risk management, including
coastal planning and early warning. Explicit computation of site-specific PTHA, with an
adequate discretization of source scenarios combined with high-resolution numerical
inundation modelling, has been out of reach with existing models and computing
capabilities, with tens to hundreds of thousands of moderately intensive numerical
simulations being required for exhaustive uncertainty quantification. In recent years, more
efficient GPU-based High-Performance Computing (HPC) facilities, together with efficient
GPU-optimized shallow water type models for simulating tsunami inundation, have now made
local long-term hazard assessment feasible. A workflow has been developed with three main
stages: 1) Site-specific source selection and discretization, 2) Efficient numerical inundation
simulation for each scenario using the GPU-based Tsunami-HySEA numerical tsunami
propagation and inundation model using a system of nested topo-bathymetric grids, and
3) Hazard aggregation. We apply this site-specific PTHA workflow here to Catania, Sicily, for
tsunamigenic earthquake sources in the Mediterranean. We illustrate the workflows of the
PTHA as implemented for High-Performance Computing applications, including preliminary
simulations carried out on intermediate scale GPU clusters. We show how the local hazard
analysis conducted here produces a more fine-grained assessment than is possible with a
regional assessment.