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dc.contributor.authorSánchez-Muñoz, Alfonso 
dc.contributor.authorVicioso-Recio, Luis Prudencio 
dc.contributor.authorSantonja, Angela
dc.contributor.authorAlvaréz, Martina
dc.contributor.authorPlata-Fernández, Yéssica
dc.contributor.authorMiramón, José
dc.contributor.authorZarcos, Irene
dc.contributor.authorRamírez-Tortosa, César
dc.contributor.authorMontes-Torres, Julio 
dc.contributor.authorJerez-Aragonés, José Manuel 
dc.contributor.authorDe Luque, Vanessa
dc.contributor.authorLlácer, Casilda
dc.contributor.authorFernández-De Sousa, C.E.
dc.contributor.authorPérez-Villa, Lidia 
dc.contributor.authorAlba-Conejo, Emilio 
dc.date.accessioned2024-05-13T09:20:49Z
dc.date.available2024-05-13T09:20:49Z
dc.date.issued2018-02
dc.identifier.citationSánchez-Muñoz A, Vicioso L, Santonja A, Álvarez M, Plata-Fernández Y, Miramón J, Zarcos I, Ramírez-Tortosa CL, Montes-Torres J, Jerez JM, de Luque V, Llácer C, Fernández-De Sousa CE, Pérez-Villa L, Alba E. Male breast cancer: correlation between immunohistochemical subtyping and PAM50 intrinsic subtypes, and the subsequent clinical outcomes. Mod Pathol. 2018 Feb;31(2):299-306. doi: 10.1038/modpathol.2017.129. Epub 2017 Oct 6. PMID: 28984296.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/31268
dc.descriptionPolítica de acceso abierto tomada de: https://beta.sherpa.ac.uk/id/publication/4003es_ES
dc.description.abstractMale breast cancer is a rare disease that is still poorly understood. It is mainly classified by immunohistochemistry as a luminal disease. In this study, we assess for the first time the correlation between molecular subtypes based on a validated six-marker immunohistochemical panel and PAM50 signature in male breast cancer, and the subsequent clinical outcome of these different subtypes. We collected 67 surgical specimens of invasive male breast cancer from four different Spanish pathology laboratories. Immunohistochemical staining for the six-marker panel was performed on tissue microarrays. PAM50 subtypes were determined in a research-use-only nCounter Analysis System. We explored the association of immunohistochemical and PAM50 subtypes. Overall survival and disease-free survival were analyzed in the different subtypes of each classification. The distribution of tumor molecular subtypes according PAM50 was: 60% luminal B, 30% luminal A and 10% human epidermal growth factor receptor 2 (Her2) enriched. Only one Her2-enriched tumor was also positive by immunohistochemistry and was treated with trastuzumab. None of the tumors were basal-like. Using immunohistochemical surrogates, 51% of the tumors were luminal B, 44% luminal A, 4% triple-negative and 1% Her2-positive. The clinicopathological characteristics did not differ significantly between immunohistochemical and PAM50 subtypes. We found a significant worse overall survival in Her2-enriched compared with luminal tumors. Male breast cancer seems to be mainly a genomic luminal disease with a predominance of the luminal B subtype. In addition, we found a proportion of patients with Her2-negative by immunohistochemistry but Her2-enriched profile by PAM50 tumors with a worse outcome compared with luminal subtypes that may benefit from anti-Her2 therapies.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMamas - Cánceres_ES
dc.subjectCáncer - Hombreses_ES
dc.subjectCáncer - Aspectos inmunológicoses_ES
dc.subject.otherMale breast canceres_ES
dc.subject.otherPAM50 intrinsic subtypeses_ES
dc.subject.otherImmunohistochemical subtypinges_ES
dc.subject.otherOutcomees_ES
dc.titleMale breast cancer: correlation between immunohistochemical subtyping and PAM50 intrinsic subtypes, and the subsequent clinical outcomeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Medicinaes_ES
dc.identifier.doi10.1038/modpathol.2017.129
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones_ES


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