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dc.contributor.authorPerez-Carrascosa, Francisco M
dc.contributor.authorGómez-Peña, Celia
dc.contributor.authorEcheverría, Ruth
dc.contributor.authorJimenez Moleon, Jose Juan
dc.contributor.authorMelchor, Juan M
dc.contributor.authorGarcía-Ruiz, Antonio J. 
dc.contributor.authorNavarro-Espigares, José Luis
dc.contributor.authorCabeza Barrera, Jose
dc.contributor.authorMartin-Olmedo, Piedad
dc.contributor.authorOrtigosa-García, Juan Carlos
dc.contributor.authorArrebola, Juan Pedro
dc.date.accessioned2024-02-09T11:09:55Z
dc.date.available2024-02-09T11:09:55Z
dc.date.issued2021-07-02
dc.identifier.citationFrancisco Miguel Pérez-Carrascosa, Celia Gómez-Peña, Ruth Echeverría, José Juan Jiménez Moleón, Juan Manuel Melchor, Antonio García-Ruiz, José Luis Navarro-Espigares, José Cabeza-Barrera, Piedad Martin-Olmedo, Juan Carlos Ortigosa-García, Juan Pedro Arrebola, Historical exposure to persistent organic pollutants and cardiovascular disease: A 15-year longitudinal analysis focused on pharmaceutical consumption in primary care, Environment International, Volume 156, 2021, 106734, ISSN 0160-4120, https://doi.org/10.1016/j.envint.2021.106734.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/30277
dc.descriptionCC BY-NC-NDes_ES
dc.description.abstractObjectives: To explore the potential contribution of historical POP exposure to 15-year pharmaceutical consumption in relation to CVD. Methods: This study is framed within GraMo adult cohort. Participants (n = 387) were recruited in two hospitals in Granada province, Southern Spain (2003–2004). Historical exposure to 5 OCPs and 3 non-dioxine-like PCBs was estimated by analysing adipose tissue concentrations at recruitment. Pharmaceutical consumption from recruitment until year 2017 was quantified by reviewing dispensation databases. Average consumption increase (ACI) in CVD medication was calculated by subtracting average consumption in 2002 to the average yearly consumption during follow-up. ACI was expressed as Defined Daily Dose (DDD)/year units. Data analyses were carried out using a multivariable multinomial logistic regression and weighted quantile sum regression (WQS), with ACI categorized in quartiles (Q) as the dependent variable. Results: Concentrations of most pollutants showed a positive trend with the quartiles of ACI. Particularly, PCB- 153 showed increasing and statistically significant odds ratios (ORs) for Q2 (OR: 1.27, 95% confidence interval (CI): 1.07–1.52), Q3 (OR: 1.49, 95 %CI: 1.17–1.88) and Q4 (OR: 1.42, 95 %CI: 1.13–1.78) vs Q1. Similarly, beta-hexachlorocyclohexane (β-HCH) also showed increasing ORs, that reached statistical significance in Q4 (OR: 1.36, 95 %CI: 1.06–1.74) vs Q1. These findings were corroborated by WQS analyses, that revealed a significant mixture effect, predominantly accounted for by PCB-153 and β-HCH.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectSistema cardiovascular - Enfermedadeses_ES
dc.subjectSistema cardiovascular - Efectos de los medicamentoses_ES
dc.subject.otherOrganochlorine pesticideses_ES
dc.subject.otherPolychlorinated biphenylses_ES
dc.subject.otherPersistent Organic Pollutantses_ES
dc.subject.otherCardiovascular diseasees_ES
dc.subject.otherPharmaceutical consumptiones_ES
dc.subject.otherHealth expenditurees_ES
dc.titleHistorical exposure to persistent organic pollutants and cardiovascular disease: A 15-year longitudinal analysis focused on pharmaceutical consumption in primary carees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1016/j.envint.2021.106734
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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