Mostrar el registro sencillo del ítem

dc.contributor.authorRego, Alejandro
dc.contributor.authorPilo, Jesús
dc.contributor.authorGarcía-Flores, Libia Alejandra
dc.contributor.authorBoughanem, Hatim
dc.contributor.authorMartín Nuñez, Gracia Maria
dc.contributor.authorMacías-González, Manuel
dc.date.accessioned2024-02-08T10:34:59Z
dc.date.available2024-02-08T10:34:59Z
dc.date.issued2023-12-01
dc.identifier.urihttps://hdl.handle.net/10630/30095
dc.description.abstractAlthough the etiology of colorectal cancer (CRC) is multifactorial and complex, due to the interaction of altered environmental and genetic mechanisms, obesity is considered a crucial risk factor in the initiation and progression of CRC. Alterations in epigenetic mechanisms, such as changes in the methylation pattern of certain genes, have been shown to have a clear effect on tumorigenesis and progression. In recent years, mounting evidence has revealed that the RNA modification machinery is often altered in human cancers, highlighting their enormous potential as drug targets or markers for diagnosis and early detection in obese subjects. Our objective was to identify in circulating leukocytes alterations in the epi-transcriptomic profile (m6A) of circulating leukocytes and their association with dysregulation of the RNA splicing machinery and alterations of the inflammatory response in patients with obesity-associated CRC. The study revealed significant differences in m6A RNA methylation of circulating leukocytes both between CRC patients and healthy overweight or obese patients, as well as between CRC patients with different BMI. It was also observed that obesity in CRC causes alterations in the expression of spliceosome components and factors related to RNA splicing and genes related to the inflammasome and inflammatory response in circulating leukocytes. Obesity in CRC is associated with alterations in the epitranscriptomic profile (m6A) in circulating leukocytes, in addition to alterations in the gene expression of the splicing machinery and inflammatory regulation.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCáncer - Etiologíaes_ES
dc.subjectCarcinogénesises_ES
dc.subject.otherEpitranscriptomicses_ES
dc.subject.otherN6-methyladenosinees_ES
dc.subject.otherTumorigenesises_ES
dc.subject.otherCanceres_ES
dc.subject.otherSplicinges_ES
dc.subject.otherInflammationes_ES
dc.subject.otherObesityes_ES
dc.titleStudy of the impact of m6A RNA methylation in altered molecular mechanisms in colorectal cancer and its association with obesityes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle2023 EASO ECN Winter Schooles_ES
dc.relation.eventplaceAntalya, Türkiyees_ES
dc.relation.eventdate30 November 2023es_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem