Mostrar el registro sencillo del ítem

dc.contributor.authorArrabal-García, Pilar María 
dc.contributor.authorVisser, Rick 
dc.contributor.authorSantos-Ruiz, Leonor 
dc.contributor.authorBecerra-Ratia, José 
dc.contributor.authorCifuentes-Rueda, Manuel 
dc.date.accessioned2024-02-01T07:40:09Z
dc.date.available2024-02-01T07:40:09Z
dc.date.issued2013
dc.identifier.urihttps://hdl.handle.net/10630/29554
dc.description.abstractAmong the osteogenic growth factors used for bone tissue engineering, bone morphogenetic proteins (BMPs) are the most extensively studied for use in orthopaedic surgery. BMP-2 and BMP-7 have been widely investigated for developing therapeutic strategies and are the only two approved for use in several clinical applications. Due to the chemical and biological characteristics of these molecules, their authorised uses are always in combination with a carrier based on collagen type I. Although the use of these growth factors is considered safe in the short term, the very high doses needed to obtain significant osteoinduction make these treatments expensive and their long-term safety uncertain, since they are highly pleiotropic and have the capacity to induce ectopic ossification in the surrounding tissues. Therefore it is necessary to improve the currently used BMP-collagen system in terms of efficiency, biosecurity and costs. There are several strategies to increase the clinical effectiveness of these treatments. In this review we summarize the most promising results and our related work focused on this field through two different approaches: i) the development of recombinant BMPs with additional features, and ii) complementing these systems with other growth factors or molecules to enhance or accelerate osteogenesis.es_ES
dc.description.sponsorshipMICINN (BIO2009-13903-C01-01) MINECO (BIO2012-34960) Junta de Andalucía (P11-CVI07245) ISCiii, RETICS, Red Española de Terapia Celular (TerCel) (RD12/0019/0032) ISCiii, CIBER-BBN (CB06/01/1015)es_ES
dc.language.isoenges_ES
dc.publisherSociedad de Biología de Chilees_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHuesos - Crecimientoes_ES
dc.subject.otherBMPs (Bone Morphogenetic Proteins)es_ES
dc.subject.otherBMP2es_ES
dc.subject.otherGrowth Factorses_ES
dc.subject.otherFGFs (Fibroblast Growth Factors)es_ES
dc.subject.otherFGF2es_ES
dc.subject.otherRecombinant proteinses_ES
dc.subject.otherOsteogenesises_ES
dc.subject.otherRGD Peptidees_ES
dc.subject.otherDelivery Systemses_ES
dc.subject.otherBinding domainses_ES
dc.subject.otherMesenchymal Stem Cell (MSC)es_ES
dc.subject.otherOpen tibial fracturees_ES
dc.subject.otherSpinal fusiones_ES
dc.subject.otherFusion proteines_ES
dc.titleOsteogenic molecules for clinical applications: Improving the BMP-collagen systemes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doi10.4067/S0716-97602013000400013
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem