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dc.contributor.authorSánchez-Mejías, Elisabeth 
dc.contributor.authorNúñez-Díaz, Cristina
dc.contributor.authorSánchez-Varo, Raquel María 
dc.contributor.authorGómez-Arboledas, Ángela
dc.contributor.authorGarcía-León, Juan Antonio 
dc.contributor.authorFernández-Valenzuela, Juan José
dc.contributor.authorMejías-Ortega, Marina
dc.contributor.authorTrujillo-Estrada, Laura Isabel 
dc.contributor.authorBaglietto-Vargas, David
dc.contributor.authorMoreno-González, Inés
dc.contributor.authorDávila-Cansino, José Carlos 
dc.contributor.authorVitorica, Javier
dc.contributor.authorGutiérrez-Pérez, Antonia 
dc.date.accessioned2024-01-30T13:18:39Z
dc.date.available2024-01-30T13:18:39Z
dc.date.created2024
dc.date.issued2020-03
dc.identifier.citationSanchez-Mejias E, Nuñez-Diaz C, Sanchez-Varo R, Gomez-Arboledas A, Garcia-Leon JA, Fernandez-Valenzuela JJ, Mejias-Ortega M, Trujillo-Estrada L, Baglietto-Vargas D, Moreno-Gonzalez I, Davila JC, Vitorica J, Gutierrez A. Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients. Brain Pathol. 2020 Mar;30(2):345-363es_ES
dc.identifier.urihttps://hdl.handle.net/10630/29420
dc.description.abstractNeuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer's disease (AD). Defective GABAergic neuronal functions may lead to cortical network hyperactivity and aberrant neuronal oscillations and in consequence, generate a detrimental alteration in memory processes. In this study, using immunohistochemical and stereological approaches, we report that the two major and non-overlapping groups of inhibitory interneurons (SOM-cells and PV-cells) displayed distinct vulnerability in the perirhinal cortex of APP/PS1 mice and AD patients. SOM-positive neurons were notably sensitive and exhibited a dramatic decrease in the perirhinal cortex of 6-month-old transgenic mice (57% and 61% in areas 36 and 35, respectively) and, most importantly, in AD patients (91% in Braak V-VI cases). In addition, this interneuron degenerative process seems to occur in parallel, and closely related, with the progression of the amyloid pathology. However, the population expressing PV was unaffected in APP/PS1 mice while in AD brains suffered a pronounced and significant loss (69%). As a key component of cortico-hippocampal networks, the perirhinal cortex plays an important role in memory processes, especially in familiarity-based memory recognition. Therefore, disrupted functional connectivity of this cortical region, as a result of the early SOM and PV neurodegeneration, might contribute to the altered brain rhythms and cognitive failures observed in the initial clinical phase of AD patients. Finally, these findings highlight the failure of amyloidogenic AD models to fully recapitulate the selective neuronal degeneration occurring in humans.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAlzheimer, Enfermedad dees_ES
dc.subject.otherAlzheimeres_ES
dc.subject.otherGABAes_ES
dc.subject.otherHuman braines_ES
dc.subject.otherInterneurones_ES
dc.subject.otherParvalbumines_ES
dc.subject.otherSomatostatines_ES
dc.subject.otherTransentorhinal cortexes_ES
dc.subject.otherTransgenic mousees_ES
dc.titleDistinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patientses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doi10.1111/bpa.12785
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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