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dc.contributor.authorGarcía-Pinel, Beatriz
dc.contributor.authorOrtega Rodríguez, Alicia
dc.contributor.authorPorras Alcalá, Cristina
dc.contributor.authorCabeza, Laura
dc.contributor.authorContreras-Cáceres, Rafael
dc.contributor.authorOrtiz, Raúl
dc.contributor.authorDíaz-Morilla, Amelia 
dc.contributor.authorMoscoso, Ana
dc.contributor.authorSarabia-García, Francisco Ramón 
dc.contributor.authorPrados, Jose
dc.contributor.authorLópez-Romero, Juan Manuel 
dc.contributor.authorMelguizo, Consolación
dc.date.accessioned2024-01-30T12:37:06Z
dc.date.available2024-01-30T12:37:06Z
dc.date.issued2020-04-19
dc.identifier.citationBeatriz Garcia-Pinel, Alicia Ortega-Rodríguez, Cristina Porras-Alcalá, Laura Cabeza, Rafael Contreras-Cáceres, Raul Ortiz, Amelia Díaz, Ana Moscoso, Francisco Sarabia, José Prados, Juan M. López-Romero & Consolación Melguizo (2020) Magnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug delivery, Artificial Cells, Nanomedicine, and Biotechnology, 48:1, 1022-1035, DOI: 10.1080/21691401.2020.1773488es_ES
dc.identifier.urihttps://hdl.handle.net/10630/29408
dc.description.abstractHere, temperature-sensitive hybrid poly(N-isopropylacrylamide) (pNIPAM) nanosystems with magnetic response are synthesised and investigated for controlled release of 5-fluorouracil (5FU) and oxaliplatin (OXA). Initially, magnetic nanoparticles (@Fe3O4) are synthesised by co-precipitation approach and functionalised with acrylic acid (AA), 3-butenoic acid (3BA) or allylamine (AL) as comonomers. The thermo-responsive polymer is grown by free radical polymerisation using N-isopropylacrylamide (NIPAM) as monomer, N,N’-methylenbisacrylamide (BIS) as cross-linker, and 2,2’-azobis(2-methylpropionamidene) (V50) as initiator. We evaluate particle morphology by transmission electron microscopy (TEM) and particle size and surface charge by dynamic light scattering (DLS) and Z-potential (ZP) measurements. These magnetically active pNIPAM@ nanoformulations are loaded with 5-fluorouracil (5FU) and oxaliplatin (OXA) to determine loading efficiency, drug content and release as well as the cytotoxicity against T-84 colon cancer cells. Our results show high biocompatibility of pNIPAM nanoformulations using human blood cells and cultured cells. Interestingly, the pNIPAM@Fe3O4-3BA + 5FU nanoformulation significantly reduces the growth of T-84 cells (57% relative inhibition of proliferation). Indeed, pNIPAM-co-AL@Fe3O4-AA nanosystems produce a slight migration of HCT15 cells in suspension in the presence of an external magnetic field. Therefore, the obtained hybrid nanoparticles can be applied as a promising biocompatible nanoplatform for the delivery of 5FU and OXA in the improvement of colon cancer treatments.es_ES
dc.language.isoenges_ES
dc.publisherTaylor and Francises_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectQuímica farmacéuticaes_ES
dc.subject.other5-fluorouraciles_ES
dc.subject.otherpNIPAM nanosystemses_ES
dc.subject.otherColon canceres_ES
dc.subject.otherExternal magnetic fieldes_ES
dc.subject.otherMagnetic nanoparticleses_ES
dc.subject.otherOxaliplatines_ES
dc.titleMagnetically active pNIPAM nanosystems as temperature-sensitive biocompatible structures for controlled drug deliveryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1080/21691401.2020.1773488
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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