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dc.contributor.authorClaros-Díaz, Manuel Gonzalo 
dc.contributor.authorArroyo, Macarena
dc.contributor.authorBautista-Moreno, Rocío 
dc.contributor.authorLarrosa-Jiménez, Rafael 
dc.contributor.authorCobo, Manuel Ángel
dc.date.accessioned2024-01-26T09:55:58Z
dc.date.available2024-01-26T09:55:58Z
dc.date.issued2019
dc.identifier.citationArroyo M, Bautista R, Larrosa R, Cobo MÁ, Claros MG. 2019. Biomarker potential of repetitive-element tran- scriptome in lung cancer. PeerJ 7:e8277 http://doi.org/10.7717/peerj.8277es_ES
dc.identifier.urihttps://hdl.handle.net/10630/29267
dc.description.abstractSince repetitive elements (REs) account for nearly 53% of the human genome, profiling its transcription after an oncogenic change might help in the search for new biomarkers. Lung cancer was selected as target since it is the most frequent cause of cancer death. A bioinformatic workflow based on well-established bioinformatic tools (such as RepEnrich, RepBase, SAMTools, edgeR and DESeq2) has been developed to identify differentially expressed RNAs from REs. It was trained and tested with public RNA- seq data from matched sequencing of tumour and healthy lung tissues from the same patient to reveal differential expression within the RE transcriptome. Healthy lung tissues express a specific set of REs whose expression, after an oncogenic process, is strictly and specifically changed. Discrete sets of differentially expressed REs were found for lung adenocarcinoma, for small-cell lung cancer, and for both cancers. Differential expression affects more HERV-than LINE-derived REs and seems biased towards down- regulation in cancer cells. REs behaving consistently in all patients were tested in a different patient cohort to validate the proposed biomarkers. Down-regulation of AluYg6 and LTR18B was confirmed as potential lung cancer biomarkers, while up- regulation of HERVK11D-Int is specific for lung adenocarcinoma and up-regulation of UCON88 is specific for small cell lung cancer. Hence, the study of RE transcriptome might be considered another research target in cancer, making REs a promising source of lung cancer biomarkers.es_ES
dc.language.isoenges_ES
dc.publisherPeerJes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMarcadores bioquímicoses_ES
dc.subject.otherRepetitive elementes_ES
dc.subject.otherLung canceres_ES
dc.subject.otherDifferential expressiones_ES
dc.subject.otherBiomarkeres_ES
dc.subject.otherTranscriptomees_ES
dc.titleBiomarker potential of repetitive-element transcriptome in lung canceres_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doi10.7717/peerj.8277
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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