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dc.contributor.authorNiu, Hao
dc.contributor.authorSolis-Muñoz, Pablo
dc.contributor.authorGarcía-Cortés, Miren 
dc.contributor.authorSanabria-Cabrera, Judith Adriana 
dc.contributor.authorRobles-Díaz, María Mercedes 
dc.contributor.authorRomero-Flores, Rocío
dc.contributor.authorBonilla-Toyos, Elvira
dc.contributor.authorOrtega-Alonso, Aida
dc.contributor.authorPinazo-Bandera, José M.
dc.contributor.authorCabello-Porras, María Rosario 
dc.contributor.authorBessone, Fernando
dc.contributor.authorHernandez, Nelia
dc.contributor.authorLucena-González, María Isabel 
dc.contributor.authorAndrade-Bellido, Raúl Jesús 
dc.contributor.authorMedina-Cáliz, Inmaculada 
dc.contributor.authorAlvarez-Alvarez, Ismael
dc.date.accessioned2024-01-18T12:24:56Z
dc.date.available2024-01-18T12:24:56Z
dc.date.issued2023-12-08
dc.identifier.citationHao Niu, Pablo Solis-Muñoz, Miren García-Cortés, Judith Sanabria-Cabrera, Mercedes Robles-Diaz, Rocío Romero-Flores, Elvira Bonilla-Toyos, Aida Ortega-Alonso, José M. Pinazo-Bandera, María R. Cabello, Fernando Bessone, Nelia Hernandez, M. Isabel Lucena, Raúl J. Andrade, Inmaculada Medina-Caliz, Ismael Alvarez-Alvarez, Prior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratification, Pharmacological Research, Volume 199, 2024, 107030, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2023.107030. (https://www.sciencedirect.com/science/article/pii/S1043661823003869)es_ES
dc.identifier.urihttps://hdl.handle.net/10630/28890
dc.description.abstractThe impact of prior drug allergies (PDA) on the clinical features and outcomes of patients who develop idiosyncratic drug-induced liver injury (DILI) is largely unknown. We aimed to assess the clinical presentation and outcomes of DILI patients based on the presence or absence of PDA and explore the association between culprit drugs responsible for DILI and allergy. We analysed a well-vetted cohort of DILI cases enrolled from the Spanish DILI Registry. Bootstrap-enhanced least absolute shrinkage operator procedure was used in variable selection, and a multivariable logistic model was fitted to predict poor outcomes in DILI. Of 912 cases with a first episode of DILI, 61 (6.7%) had documented PDA. Patients with PDA were older (p = 0.009), had higher aspartate aminotransferase (AST) levels (p = 0.047), lower platelet count (p = 0.011) and higher liver-related mortality than those without a history of drug allergies (11% vs. 1.6%, p < 0.001). Penicillin was the most common drug associated with PDA in DILI patients (32%). A model including PDA, nR-based type of liver injury, female sex, AST, total bilirubin, and platelet count showed an excellent performance in predicting poor outcome in patients from the Spanish DILI Registry (area under the ROC curve [AUC] 0.887; 95% confidence interval [CI] 0.794 – 0.981) and the LATINDILI Network (AUC 0.932; 95% CI 0.884 – 0.981). Patients with suspected DILI should be screened for PDA as they would require a close monitoring for early detection of worsening clinical course.es_ES
dc.description.sponsorshipFunding for open access charge: Universidad de Málaga/CBUA. This work was supported by grants of Instituto de Salud Carlos III (ISCIII), cofounded by Fondo Europeo de Desarrollo Regional – FEDER, cofounded by European Union (grant number PI21/01248), and by the Agencia Española de Medicamentos y Productos Sanitarios. CIBERehd is funded by ISCIII. HN holds a postdoctoral research contract funded by Junta de Andalucía (POSTDOC_21_00780). JSC holds a Juan Rodés contract (JR21/00066), JMP-B holds a Rio Hortega contract (CM21/00074), and IAA holds a Sara Borrell contract (CD20/00083), funded by ISCIII. This project has received funding from the European Horizon´s research and innovation program HORIZON-HLTH-2022-STAYHLTH-02 under agreement No 101095679. Open Access funding provided thanks to the CRUE-CSIC agreement with Elsevier.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHígadoes_ES
dc.subjectAlergias a los medicamentoses_ES
dc.subjectPronóstico médicoes_ES
dc.subjectAprendizaje automático (Inteligencia artificial)es_ES
dc.subject.otherDrug-induced liver injuryes_ES
dc.subject.otherAllergyes_ES
dc.subject.otherAcute liver failurees_ES
dc.subject.otherPrognosises_ES
dc.subject.otherMachine learninges_ES
dc.titlePrior drug allergies are associated with worse outcome in patients with idiosyncratic drug-induced liver injury: A machine learning approach for risk stratificationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Medicinaes_ES
dc.identifier.doi10.1016/j.phrs.2023.107030
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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