This chapter has its origin in a post whose title translates as “The Digital Humanities: A Framework for Critical Reflection about Culture” (Rodríguez-Ortega, “Humanidades digitales”), published in March 2016. The post also reflects the deliberations of a conference at the University of Granada for the launch of the project “Digital Social Sciences and Digital Humanities of the South” (#CSHDSUR: ). The aim was to explore how the interaction of digital social sciences with digital humanities in the South could be defined and constructed. That is also the objective of this text. To my main ideas in the post, I have now added some other thoughts on which I have had the opportunity to reflect over the intervening years. My ultimate aim is to provide material for debate and critical discussion.