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dc.contributor.authorCastro-Zavala, Adriana
dc.contributor.authorMelgar-Locatelli, Sonia
dc.contributor.authorMañas-Padilla, María del Carmen
dc.contributor.authorRodríguez-Pérez, Celia
dc.contributor.authorCastilla-Ortega, María Estela 
dc.date.accessioned2023-10-13T08:49:57Z
dc.date.available2023-10-13T08:49:57Z
dc.date.issued2023
dc.identifier.urihttps://hdl.handle.net/10630/27816
dc.description.abstractDepression is one of the mental disorders that significantly affects today's society and calls for new treatments. In recent years, the gut microbiota has emerged as a key modulator of behaviour and mood due to the existence of the gut-brain microbiota axis. Environmental factors such as early stress or diet can negatively impact the predisposition to develop a mental disorder and the composition of the gut microbiota. Prebiotics are functional foods that stimulate the growth or activity of intestinal bacteria, providing benefits to the host's health. Polyphenols, such as those found in cocoa, possess prebiotic properties. Therefore, the consumption of polyphenols derived from cocoa could be a therapeutic pathway for mental disorders. Our study aimed to evaluate the impact of maternal separation with early weaning (MSEW) on depression and anxiety-like behaviours in male and female mice and neuroinflammatory markers in the brain. We also explore if the modulation of the gut microbiota through cocoa-derived polyphenols could ameliorate these behavioural and molecular alterations induced by early stress. Results showed higher immobility time in the tail suspension test in those mice exposed to MSEW and more depressive-like behaviour in females compared with males. Regarding results in the elevated plus maze, we found reduced travelled distance and time in open arms in MSEW mice. Additionally, we showed higher time in open arms in MSEW female mice treated with polyphenols than MSEW females that received a control diet, suggesting a reduction in anxiety like-behaviour. In conclusion, our findings support that early-life stress increases susceptibility to depression and anxiety-like behaviours in mice. Additionally, sex differences were observed, with females showing more pronounced depressive- and anxiety-like behaviour. Moreover, we highlight that modulation of gut microbiota could be a potential therapeutic target in mood disorders.es_ES
dc.description.sponsorshipProyect PID2020-114374RB-I00 by MCIN/AEI/10.13039/501100011033, Junta de Andalucía POSTDOC21_00365, Universidad de Málaga BI-2022_05, Universidad de Málaga Investigación e Innovación Proyect P21_00777. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEstrés (Fisiología)es_ES
dc.subjectCacao - Uso terapéutico - Ensayoses_ES
dc.subjectPolifenoles - Uso terapéutico - Ensayoses_ES
dc.subject.otherEarly-life stresses_ES
dc.subject.otherGut microbiotaes_ES
dc.subject.otherMicees_ES
dc.subject.otherPolyphenolses_ES
dc.titleEffects of cocoa-derived polyphenols treatment in regulating the adverse impacts of early-life stress in male and female mice.es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Psicología y Logopediaes_ES
dc.relation.eventtitle36th ECNP congresses_ES
dc.relation.eventplaceBarcelona, Españaes_ES
dc.relation.eventdate7 de octubre del 2023es_ES
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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