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dc.contributor.authorVegas-Gómez, Laura
dc.contributor.authorFernández-Valenzuela, Juan José
dc.contributor.authorGutiérrez-Pérez, Antonia 
dc.contributor.authorMoreno-González, Inés
dc.date.accessioned2023-09-29T06:22:44Z
dc.date.available2023-09-29T06:22:44Z
dc.date.created2023
dc.date.issued2023
dc.identifier.urihttps://hdl.handle.net/10630/27692
dc.description.abstractBackground: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong association between depression in later life and AD. The age of onset of AD has been shown to be accelerated in patients with mild cognitive impairment (MCI) with a history of depression, and women appear to be particularly more vulnerable to this condition. In addition, individuals with MCI who present depressive symptoms have an elevated burden of amyloid-beta, one of the featured toxic proteins associated with Alzheimer's pathology, and a higher risk of developing AD compared to non-depressed MCI patients. Although it has been described that some transgenic models of AD can develop signs similar to depression in advanced stages, it is unknown whether late-life depression can accelerate tau-associated pathology and, therefore, acting as a risk factor for AD. Method: In this study, we induced chronic unpredictable mild stress (CUMS) in P301S tau transgenic mice to determine whether depression is a cause, rather than a consequence, of the development of AD. Result: The results of our study indicate that the induction of CUMS in transgenic animals induces phenotypic changes related to a depressive state. Conclusion: The findings obtained after inducing late-life depression-like in P301S mice indicate that depression could be considered a risk factor for AD, by accelerating tau aggregation and worsening clinical signs.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.publisherIBRO/FENSes_ES
dc.rightsinfo:eu-repo/semantics/embargoedAccesses_ES
dc.subjectAlzheimer, Enfermedad dees_ES
dc.subjectDepresión en ancianoses_ES
dc.subject.otherDepressiones_ES
dc.subject.otherAlzheimeres_ES
dc.subject.otherTau aggregationes_ES
dc.titleLate-life depression accelerates cognitive decline in a tauopathy mouse modeles_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle11th IBRO World Congress of Neurosciencees_ES
dc.relation.eventplaceGranada, Españaes_ES
dc.relation.eventdate9/09/2023-13/09/2023es_ES


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