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dc.contributor.authorInfantes-López, M. Inmaculada
dc.contributor.authorDomínguez-Maqueda, Marta
dc.contributor.authorCerezo Ortega, Isabel M.
dc.contributor.authorZambrana-Infantes, Emma
dc.contributor.authorMoriñigo-Gutiérrez, Miguel Ángel 
dc.contributor.authorPedraza-Benítez, María del Carmen 
dc.contributor.authorPérez-Martín, Margarita 
dc.date.accessioned2023-09-28T06:33:10Z
dc.date.available2023-09-28T06:33:10Z
dc.date.created2023
dc.date.issued2023
dc.identifier.urihttps://hdl.handle.net/10630/27685
dc.descriptionComunicación de tipo Pósteres_ES
dc.description.abstractThe gut microbiome has arisen as one important modulator of general health, including brain function. In fact, disturbances in brain health are commonly mirrored in the microbiome, which could be contributing to pathology. One of the most common brain disorders is depression, which is tightly linked to environmental factors such as stress and drives alterations in regular behavior. However, not much is known about the role of the gut microbiome in response to stress and its relationship to behavior. In this study, the social defeat stress (SDS) paradigm was used as a depressive-like symptoms inducer in 8 w.o. male C57BL/6J mice for 10 days. Mice were segregated in stress resilient and sensitive according to behavior using K-means clustering and behavioral data was interpreted using principal component analysis. Then, the mice microbiome was extracted from fecal pellets after the stress protocol. DNA was extracted and purified followed by 16S (V3-V4) region amplification for sequencing. These data were analyzed to obtain diversity indexes and identify bacterial taxa within samples and groups. Data revealed that mice responded differently to the same stressor. Half the mice were found to have mild depressive-like symptoms whereas the other half showed profound alterations. Behavioral data was found to be explained in three factors: anhedonia, exploration, and motility. Stressed mice showed overall differences in their microbiome, being less diverse and populations associated with higher inflammation. Moreover, the healthy gut associated Verrucomicrobiae class was only identified in stress resilient mice, suggesting a possible relationship with their behavioral phenotype. Altogether, these results show a different behavioral response to stress in animals that reflects in their microbiome, which could be a key factor in determining stress resilience.es_ES
dc.description.sponsorshipThis study was supported by Ministerio de Ciencia e Innovación - Plan Nacional I+D+I from Spain (PID2020-117464RB-I00) to CP and MP-M; FEDER/Junta de Andalucía - Proyectos I+D+I en el marco del Programa Operativo FEDER Andalucía 2014-2020 (UMA20-FEDERJA-112) to CP and MP-M; Consejería de Conocimiento, Investigación y Universidades, Junta de Andalucía (P20_00460) to CP. PC-P has been funded by the research project PID2020-117464RB-I00. Ministerio de Educación, Cultura y Deporte from Spain (FPU19/03629 to Infantes-López MI). Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEstrés (Fisiología)es_ES
dc.subjectDepresión mental - Efectos del estréses_ES
dc.subjectIntestinos - Microbiología - Efectos del estréses_ES
dc.subject.otherStresses_ES
dc.subject.otherBraines_ES
dc.subject.otherGut microbiomees_ES
dc.subject.otherDepressiones_ES
dc.subject.otherBehaviores_ES
dc.titleGut microbiome specific changes in different behavioral profiles in a mouse social defeat stress model.es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleIBRO 2023es_ES
dc.relation.eventplaceGranada, Españaes_ES
dc.relation.eventdateseptiembre 2023es_ES
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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