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dc.contributor.authorAndreo-López, Juana
dc.contributor.authorCantero-Molina, Francisco
dc.contributor.authorBettinetti-Luque, Miriam
dc.contributor.authorDo Huynh, Kelly
dc.contributor.authorMinh Thu Nguyen, Marie
dc.contributor.authorCheung, Alwin
dc.contributor.authorPham Tran, Janine
dc.contributor.authorDa Cunha, Celia
dc.contributor.authorMorales-Cabello, Mario
dc.contributor.authorFatuarte Juli, Ivan
dc.contributor.authorTrujillo-Estrada, Laura Isabel 
dc.contributor.authorNúñez-Díaz, Cristina
dc.contributor.authorCadete-Martini, Alessandra
dc.contributor.authorForner, Stefania
dc.contributor.authorLaFerla, Frank
dc.contributor.authorGutiérrez-Pérez, Antonia 
dc.contributor.authorBaglietto-Vargas, David
dc.date.accessioned2023-09-15T09:02:33Z
dc.date.available2023-09-15T09:02:33Z
dc.date.issued2023
dc.identifier.urihttps://hdl.handle.net/10630/27521
dc.description.abstractAbstract text: Alzheimer’s Disease (AD) is a neurodegenerative proteinopathy in which Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prionlike process. These amyloid aggregation and propagation processes are influenced by three factors: the origin of the Aβ seed, time of incubation and host. However, the mechanism underlying the differential effect of each factor is poorly known. Previous studies have shown that the Aβ source is relevant for the amyloid process, since its pathogenicity is different according to its origin. Furthermore, recent evidence suggests that microglia plays a key role in the amyloidogenic event, and can modulate the propagation and aggregation process. Here, we seek to perform a comparative study to determine whether Aβ seeds from humans vs a familial AD line (the 3xTg-AD model) are more efficient to generate amyloid aggregates, as well as the role of the microglia in the propagation process. Methods: Amyloid seeds from AD patient (stage C for amyloid; from the Alzheimer’s Disease Research Center at UCI) and 25 mo-3xTg-AD mice were injected into the hippocampus of 7-8- month-old 3xTg-AD mice. They were analyzed 10 months post-surgery for amyloid and microglia markers. Results: Our findings demonstrated that amyloid seeds from the human patient seem to induce a more aggressive amyloid pathology compared to seeds from aged 3xTg-AD mice. Moreover, human and mice seeds differentially affect the presence of plaque-associated microglia in 3xTgAD mice. Conclusion: These results suggest that seeds from human patients seem to be more amyloidogenic than from aged 3xTg-AD mice, and also microglia cells may play a key role in this differential effect. Therefore, more profound understanding these factors will provide key insight on how amyloid pathology progresses in AD.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAlzheimer, Enfermedad dees_ES
dc.subjectAmiloidees_ES
dc.subject.otherAlzheimer's diseasees_ES
dc.subject.otherAmyloides_ES
dc.subject.otherPropagationes_ES
dc.titleHuman and mouse seeds differentially affect AB aggregation by modulating the inflammatory response.es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.relation.eventtitleInternational Brain Research Organization 2023es_ES
dc.relation.eventplaceGranada (España)es_ES
dc.relation.eventdate08/09/2023es_ES


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