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dc.contributor.authorMarrero Capitán, Ana Dácil
dc.contributor.authorOrtega Vidal, Juan
dc.contributor.authorSalido, Sofía
dc.contributor.authorCastilla, Laura
dc.contributor.authorVidal-Valenzuela, Isabel
dc.contributor.authorRodríguez-Quesada, Ana María 
dc.contributor.authorAltarejos, Joaquín
dc.contributor.authorMartínez-Póveda, Beatriz Amparo 
dc.contributor.authorMedina-Torres, Miguel Ángel 
dc.date.accessioned2023-09-12T09:06:46Z
dc.date.available2023-09-12T09:06:46Z
dc.date.created2023
dc.date.issued2023-09
dc.identifier.citationMarrero, A. D., Ortega-Vidal, J., Salido, S., Castilla, L., Vidal, I., Quesada, A. R., Altarejos, J., Martínez-Póveda, B., & Medina, M. Á. (2023). Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil. Biomedicine & Pharmacotherapy, 165, 115234.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/27484
dc.description.abstractPhenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related findings have been reported. Here, we explored the modulatory action of (−)-oleocanthal and (−)-oleacein on angiogenesis, the process by which new vessels are created from pre-existent ones, which is directly linked to tumor progression and other pathological conditions. Two in vivo models strongly sustained by angiogenesis, and an in vitro model of endothelial cells to study different steps of angiogenesis, were used. In vivo evidence pointed to the anti-angiogenic effects of both compounds in vivo. In vitro, (−)-oleacein and (−)-oleocanthal inhibited the proliferation, invasion, and tube formation of endothelial cells, and (−)-oleacein significantly repressed migration and induced apoptosis in these cells. Mechanistically, the compounds modulated signaling pathways related to survival and proliferation, all at concentrations of physiological relevance for humans. We propose (−)-oleacein and (−)-oleocanthal as good candidates for angioprevention and for further studies as modulators of angiogenesis in clinical interventions, and as interesting functional claims for the food industry. Chemical compounds studied in this article: Oleocanthal (PubChem CID: 11652416); Oleacein (PubChem CID: 18684078).es_ES
dc.description.sponsorshipPartial funding for open access charge: Universidad de Málaga / CBUA.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAceite de olivaes_ES
dc.subjectAntiangiogénicoses_ES
dc.subjectEndotelioes_ES
dc.subjectFenoleses_ES
dc.subjectCáncer - Prevenciónes_ES
dc.subject.otherMediterranean dietes_ES
dc.subject.otherCanceres_ES
dc.subject.otherVirgin Olive Oiles_ES
dc.subject.otherAngiogenesises_ES
dc.subject.otherEndothelial cellses_ES
dc.subject.otherOlea europaeaes_ES
dc.subject.otherAceite de oliva virgenes_ES
dc.subject.otherDieta mediterráneaes_ES
dc.subject.otherCélulas endotelialeses_ES
dc.subject.otherOleocanthales_ES
dc.subject.otherOleaceínaes_ES
dc.titleAnti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oiles_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doi10.1016/j.biopha.2023.115234
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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