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dc.contributor.authorLópez-de-San-Sebastián, Javier
dc.contributor.authorRodríguez-Pérez, Luis Manuel 
dc.contributor.authorAnguita-Guardia, Alba
dc.contributor.authorJiménez-Lara, Antonio Jesús 
dc.contributor.authorPáez-González, Patricia 
dc.date.accessioned2023-07-14T10:21:13Z
dc.date.available2023-07-14T10:21:13Z
dc.date.created2023-07
dc.date.issued2023
dc.identifier.urihttps://hdl.handle.net/10630/27249
dc.description.abstractGerminal matrix hemorrhages and intraventricular hemorrhages (GMH/IVH) lead to posthemorrhagic hydrocephalus (PHH), a severe cause of morbidity and mortality in premature neonates. GMH/IVH disrupts the ependyma, which forms a physical and functional barrier between the brain parenchyma and the cerebrospinal fluid (CSF). CSF circulation and physiology is also affected by ependyma disruption. Thus, ependyma is a key target when designing PHH treatments. Despite this, hydrocephalus treatments are surgical and focused on alleviating ventricular pressure by draining CSF. No therapy is currently aimed to recover the ependyma. Nevertheless, bone marrow derived mesenchymal stem cells (MSCs) are known to be great agents when dealing with inflammation. Also, exosomes have proven to be promising tools when designing anti-inflammatory treatments. Therefore, gaining insight in the treating capabilities of MSCs exosomes in PHH can be valuable. Results Differential effects in edema progression and ependymal cells ciliogenesis are found when analyzing treatments with conditioned and non-conditioned exosomes in moderate PHH and severe PHH.es_ES
dc.description.sponsorship- Universidad de Malaga. Campus de Excelencia Internacional Andalucia Tech. - Junta de Andalucia (UMA18-FEDERJA-277) - Instituto de Salud Carlos III (PI19/00778) - Cofinanciado por fondos FEDER - UE.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectHidrocefalia - Tratamientoes_ES
dc.subjectTerapia celular - Ensayoses_ES
dc.subject.otherHydrocephaluses_ES
dc.subject.otherEpendymaes_ES
dc.subject.otherPosthemorrhagic hydrocephaluses_ES
dc.subject.otherCell therapyes_ES
dc.titleTesting exosomes as a treatment for posthemorrhagic hydrocephalus.es_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle2023 Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida (SRHSB)es_ES
dc.relation.eventplaceStirling, Reino Unidoes_ES
dc.relation.eventdateJulio 2023es_ES


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