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dc.contributor.advisorCarmona-Mejías, Rita María 
dc.contributor.advisorMuñoz-Chápuli-Oriol, Ramón 
dc.contributor.authorDíaz del Moral, Sandra
dc.contributor.otherAnatomía Humana, Medicina Legal e Historia de la Cienciaes_ES
dc.date.accessioned2023-06-15T09:48:53Z
dc.date.available2023-06-15T09:48:53Z
dc.date.created2023
dc.date.issued2023-06-15
dc.date.submitted2023-03-28
dc.identifier.urihttps://hdl.handle.net/10630/26965
dc.description.abstractThe Wilms’ tumor suppressor gene (Wt1) is expressed in several cell types in the developing and adult heart, including epicardial and endothelial cells, fibroblasts and cardiomyocytes. Systemic Wt1 deletion causes the death of the embryos at midgestation, and it also induces lethality when the systemic deletion is performed in adult mice. Wt1 expression in the embryonic epicardium is essential for the correct cardiac development, but little is known about its myocardial expression in embryonic and adult heart in homeostatic and pathological conditions, using a cardiotoxic drug. To study the roles that WT1 is playing in embryonic and adult cardiomyocytes, we evaluated the consequences of its conditional deletion in two transgenic mouse models, and then analysed the histological and molecular effects of its ablation. In addition, we also analysed possible changes in the morphology and function of adult mice carrying the embryonic Wt1 deletion. To evaluate the consequences of Wt1 deletion in the adult myocardium under pathological conditions, we administered an acute and a chronic treatment of doxorubicin. Our results suggested that the myocardial Wt1 expression is essential for the correct heart development and its presence is key in adult cardiomyocytes, especially in pathological conditions.es_ES
dc.language.isoenges_ES
dc.publisherUMA Editoriales_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAntioncogenes - Tesis doctorales_ES
dc.subject.otherWt1es_ES
dc.subject.otherHeartes_ES
dc.subject.otherMyocardiumes_ES
dc.subject.otherDevelopmentes_ES
dc.subject.otherDoxorubicines_ES
dc.titleFunctions of the Wilms' tumor suppressor gene (Wt1) in embryonic and adult myocardiumes_ES
dc.typeinfo:eu-repo/semantics/doctoralThesises_ES
dc.centroFacultad de Medicinaes_ES
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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