The investigations performed in the present international Joint Doctoral Thesis (Cotutelle) have been carried out and supervised at the following institutions: “Maastricht University, Faculty of Health, Medicine and Life Sciences, Department of Pharmacology and Toxicology, NUTRIM School of Nutrition and Translational Research in Metabolism ”- Maastricht (The Netherlands) and “University of Malaga, Faculty of Medicine, Department of Pharmacology and Pediatrics, Biomedicine, Translational Research and New Health Technologies ”- Malaga (Spain), in collaboration with “Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Medical Faculty
and University Hospital of RWTH Aachen, Department of Internal Medicine III: Gastroenterology, Metabolic Disorders and Internal Intensive Medicine ”- Aachen (Germany).
As a primary objective, this dissertation aimed at contributing to the field of translational hepatology with a particular focus on liver diseases of toxic and chronic nature. In order to achieve this, a wide spectrum of biomedical research methodologies were applied, including the development of experimental models of toxic and chronic liver disease both in vitro and in vivo, the application of molecular laboratory techniques, the analysis of human liver samples from human biobanks, the design of clinical-epidemiological studies as well as the analysis of the earlier published scientific literature. The present work is introduced by a general introduction that is subsequently followed by three additional sections (listed as sections I, II and III) that correspond to the performed scientific work and main conclusions. The research shown in the first part of this manuscript were intended to widen our knowledge on drug-induced liver injury, abbreviated as “DILI” (Section I; Chapters 2-8). Here, the following thematic aspects were investigated: Evaluation of the role of the c-Jun N-terminal kinase (abbreviated as "JNK") at the hepatocytic level
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