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dc.contributor.authorPercio-Vargas, Francisco
dc.contributor.authorKesten, Christopher
dc.contributor.authorGarcía-Moreno, Álvaro
dc.contributor.authorAmorim-Silva, Vitor
dc.contributor.authorCastillo-Garriga, Araceli 
dc.contributor.authorRuiz-López, Noemí 
dc.contributor.authorSánchez-Rodríguez, Clara
dc.contributor.authorBotella-Mesa, Miguel Ángel 
dc.date.accessioned2022-09-19T10:31:07Z
dc.date.available2022-09-19T10:31:07Z
dc.date.created2022-09
dc.date.issued2022-09-14
dc.identifier.urihttps://hdl.handle.net/10630/25030
dc.description.abstractCellulose is the most abundant organic compound of all biomass on Earth1, with highly relevant roles in plant development and defence. Hence, it is essential to understand the regulation of its biosynthesis to improve the crop's tolerance to biotic and abiotic stresses. Tetratricopeptide Thioredoxin-Like (TTL)2 proteins have been identified as new players in regulating the cellulose synthase complex (CSC), uncovering their dynamic association with the CSC under cellulose-deficient conditions3. We show that TTLs are essential to maintain cellulose synthesis under salt stress, mediated by a reinforced cortical microtubule array and the stabilization of the CSCs at the plasma membrane. To perform this, TTLs interact with Cellulose Synthase 1 and promote microtubules polymerization. This dynamic behaviour of TTLs is not specific to salinity stress, and other factors that cause defects in cellulose also cause the re-localization from the cytosol to the CSC. We conclude that TTLs act as intermediates between stress sensing and the regulation of cellulose biosynthesis to overcome adverse environmental conditions. We are now investigating how changes in phosphorylation of the Intrinsic Disordered Region at the end terminus of TTLs regulate their activity and dynamic localization.es_ES
dc.description.sponsorshipThis work was funded by the Spanish Ministry for Science and Innovation (MCIN/AEI/ 10.13039/501100011033) (PGC2018-098789-B-I00) and (PID2019-107657RB-C22) to MAB, NRL and AC respectively. The Andalusian Research Plan co-financed by the European Union (PAIDI 2020-PY20_00084) to MAB and Junta de Andalucía UMA-FEDER project (grant UMA18-FEDERJA-154, UMA20-FEDERJA-023) to NRL and MAB respectively, and the Swiss National foundation to CSR (SNF 31003A_163065/1 to AM). CK was supported by a Peter und Traudl Engelhorn-Stiftung fellowship, an ETH Career Seed Grant (SEED-05 19-2) of the ETH Foundation, an Emerging Investigator grant (NNF20OC0060564) of the Novo Nordisk Foundation, and an Experiment grant (R346-2020-1546) of the Lundbeck foundation. AGM and FP were supported by BES-2015-071256 and FPU19/02219 fellowships respectively, and meeting attendance was supported by Plan Propio de Investigación, Transferencia y Divulgación Científica de la Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. VAS was supported by an Emerging Investigator research project (UMA20-FEDERJA-007) and co-financed by the “Programa Operativo FEDER 2014-2020” and by the “Consejería de Economía y Conocimiento de la Junta de Andalucía”.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectCelulosaes_ES
dc.subject.otherTTLes_ES
dc.subject.otherCellulosees_ES
dc.titleCalling for reinforcements: the role of TTL proteins in the regulación of cell wall biosynthesises_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleXVI RBMPes_ES
dc.relation.eventplaceSevilla, Españaes_ES
dc.relation.eventdate14/09/2022es_ES


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