Among all the factors that can contribute to the onset of psychopathological disorders,
stress is the main environmental factor. The hippocampus is one of the most sensitive
regions to the harmful effects of stress, in which the neurogenic process is impaired. On
the other hand, under stress situations, microglia are also affected and can trigger a
proinflammatory response, acting as anti-neurogenic cells and releasing cytokines and
other proinflammatory molecules. Knowing what happens in the early stages of stress
may be relevant to investigate the temporal aspects of the development of stressassociated
psychopathological disorders, and even their possible treatment. Therefore,
after subjecting C57BL/6J mice for 2 hours to an acute and intense stress procedure called
WIRS (water immersion restraint stress), data were analyzed to study microglia, cell
proliferation and neuronal maturation. In addition, a mediation analysis study was
conducted for data integration. The results revealed that the applied acute stress is
sufficiently intense to induce an increase in the number of microglia, accompanied by
morphometric changes, as well as negatively affecting the neuronal maturational process.
Furthermore, these data suggest that effects on the neurogenic process mediate the
microglial response to an intense acute stressor. This leads to the conclusion that this may
be the initial mechanism for any intense stress response, or may even be the first steps in
the development of the response to a chronic stressor.
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