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dc.contributor.authorLinares-Pineda, Teresa María
dc.contributor.authorBoughanem Lakhal, Hatim
dc.contributor.authorGutiérrez Repiso, Carolina
dc.contributor.authorMacías-González, Manuel
dc.contributor.authorAndrés-León, Eduardo
dc.contributor.authorRojo-Martínez, Gemma
dc.contributor.authorValdés, Sergio
dc.date.accessioned2022-07-12T09:57:20Z
dc.date.available2022-07-12T09:57:20Z
dc.date.issued2022-03-28
dc.identifier.citationLinares-Pineda, TM, Boughanem, H, Gutiérrez-Repiso, C, et al. Epigenetic changes in the metabolically healthy obese: A case-control versus a prospective study. Eur J Clin Invest. 2022; 52:e13783. doi:10.1111/eci.13783es_ES
dc.identifier.urihttps://hdl.handle.net/10630/24638
dc.description.abstractObesity has become a worldwide health problem, in which latest statistics reported an increased trend over the last years. Accordingly, long-term obesity is involved in an increased risk of developing several metabolic diseases, such as cardiovascular diseases, insulin resistance or type 2 diabetes. Although it is common to find obesity-related disorders in the majority of individuals with obesity, some of them do not show metabolic complications.1 Obese people without these metabolic disorders are defined as metabolically healthy obesity (MHO) individuals, whereas those who present metabolic complications are known as metabolically unhealthy obesity (MUO) subjects.2 Importantly, the prevalence of this healthy phenotype varies widely, in which a correct diagnosis is critical for a good prognosis.2, 3 Nevertheless, the variability of this prevalence may be due to the nature of related-study designs and the studied populations or the confounding variables considered. Therefore, conducting appropriately designed studies to evaluate important clinical research questions is crucial, to elucidate the impact of MHO in the progression of detrimental obesity-related phenotypes.4 In this case, epigenetic arises as a valuable tool for clinical applications. Epigenetic mechanisms might be implicated in the regulation of several metabolic disorders.5 However, until now, only a few studies have been conducted to understand the epigenetic changes in individuals with MHO and MUO.6-8 Therefore, we hypothesized that epigenetic changes may be involved in the development and the transition from MHO to MUO phenotype. Consequently, the aim of this study was to analyze the epigenome-wide DNA methylation study in peripheral blood mononuclear cells (PMBCs) from participants with MHO and MUO, by using two study designs, such as case-control and prospective approaches.es_ES
dc.description.sponsorshipTMLP and CGR were supported by a grant from Instituto de Salud Carlos III (FI19/00178 and CP20/00066, respectively). HB is supported by a predoctoral fellowship ("Plan Propio IBIMA 2020 A.1 Contratos predoctorales", Ref.: predoc20_002). SM, MMG and GRM are supported by Nicolas Monardes program from the Consejería de Salud de la Junta de Andalucía (RC-0008-2021, RC-0001-2018 and C-0060-2012, respectively). EAL was recipient of a postdoctoral fellowship from regional Andalusian Government (Ref: 2020_DOC_00541). This work was supported in part by a grant from the Instituto de Salud Carlos III (PI15-01350). This study has been co-funded by FEDER funds (“A way to make Europe”). CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) are ISCIII. Funding for open access charge: Universidad de Málaga / CBUAes_ES
dc.language.isospaes_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectObesidades_ES
dc.subject.otherHealth problemes_ES
dc.subject.otherObesityes_ES
dc.subject.otherMetabolic diseaseses_ES
dc.titleEpigenetic changes in the metabolically healthy obese: A case-control versus a prospective studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1111/eci.13783
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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