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dc.contributor.authorFernández-Arjona, María del Mar
dc.contributor.authorLeón-Rodríguez, Ana
dc.contributor.authorMateos-Grondona, Jesús 
dc.contributor.authorLópez-Ávalos, María Dolores 
dc.date.accessioned2022-07-04T09:05:19Z
dc.date.available2022-07-04T09:05:19Z
dc.date.issued2022-05-22
dc.identifier.citationFernández-Arjona, M. d. M., León-Rodríguez, A., Grondona, J. M., & López-Ávalos, M. D. (2022). Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity. Glia, 1– 28. https://doi.org/10.1002/glia.24217es_ES
dc.identifier.urihttps://hdl.handle.net/10630/24531
dc.description.abstractExposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy balance regulation. A model of intracerebroventricular administration of neuraminidase (NA, which is present in various pathogens such as influenza virus) was used to induce acute neuroinflammation. Evidences of primed microglia were observed 3 months after NA injection, namely (1) a heightened response of microglia located in the hypothalamic arcuate nucleus after an in vivo inflammatory challenge (high fat diet [HFD] feeding for 10 days), and (2) an enhanced response of microglia isolated from NA-treated mice and challenged in vitro to LPS. On the other hand, the consequences of a previous NA-induced neuroinflammation were further evaluated in an alternative inflammatory and hypercaloric scenario, such as the obesity generated by continued HDF feeding. Compared with sham-injected mice, NA-treated mice showed increased food intake and, surprisingly, reduced body weight. Besides, NA-treated mice had enhanced microgliosis (evidenced by increased number and reactive morphology of microglia) and a reduced population of POMC neurons in the basal hypothalamus. Thus, a single acute neuroinflammatory event may elicit a sustained state of priming in microglial cells, and in particular those located in the hypothalamus, with consequences in hypothalamic cytoarchitecture and its regulatory function upon nutritional challenges.es_ES
dc.description.sponsorshipMinisterio de Economía, Industria yCompetitividad, Gobierno de España, Grant/Award Number: SAF2017-83645; Ministeriode Educación y Formación Profesional; Funding for open access charge: Universidadde Málaga/CBUAes_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHipotálamoes_ES
dc.subject.otherShigh fat dietes_ES
dc.subject.otherHypothalamuses_ES
dc.subject.otherMHCIIes_ES
dc.subject.otherMicroglia priminges_ES
dc.subject.otherNeuroinflammationes_ES
dc.subject.otherObesityes_ES
dc.subject.otherNeuraminidasees_ES
dc.titleLong-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Cienciases_ES
dc.identifier.doihttps://doi.org/10.1002/glia.24217
dc.rights.ccAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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