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dc.contributor.authorSánchez-Rodríguez, Clara
dc.contributor.authorPercio-Vargas, Francisco
dc.contributor.authorKesten, Christopher
dc.contributor.authorGarcía-Moreno, Álvaro
dc.contributor.authorAmorim-Silva, Vitor
dc.contributor.authorCastillo-Garriga, Araceli 
dc.contributor.authorRuiz-López, Noemí 
dc.contributor.authorBotella-Mesa, Miguel Ángel 
dc.date.accessioned2022-06-27T11:34:02Z
dc.date.available2022-06-27T11:34:02Z
dc.date.created2022-06-27
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/10630/24501
dc.description.abstractIn addition to being crucial in plant development and defence, cellulose is the most abundant organic compound of all biomass on Earth1. Therefore, it is essential to elucidate the regulation of its biosynthesis to improve crop's tolerance to biotic and abiotic stresses. We have found the Tetratricopeptide Thioredoxin-Like (TTL)2 proteins as new players in the regulation of the cellulose synthase complex (CSC), identifying its dynamic association with the CSC under cellulose-deficient conditions3. We have found that TTLs are essential to maintain cellulose synthesis under salt stress, mediated by a stress-resilient cortical microtubule array and the stabilization of the CSCs at the plasma membrane. TTLs carry this out by interacting with Cellulose Synthase 1 and promoting the polymerization of microtubules. This dynamic behaviour of TTLs is not specific to salinity stress, and other modifications that cause reduced cellulose content also lead to the re-localization from the cytosol to the CSC. We conclude that TTLs act as intermediates between stress perception and regulation of cellulose biosynthesis to overcome adverse environmental conditions. All TTL proteins contain an Intrinsic Disordered Region at the end terminus, and we are now investigating how changes in phosphorylation regulate the activity and dynamic localization of these proteins.es_ES
dc.description.sponsorshipThis work was funded by the Spanish Ministry for Science and Innovation (MCIN/AEI/ 10.13039/501100011033) (PGC2018-098789-B-I00) and (PID2019-107657RB-C22) to MAB, NRL and AC respectively. The Andalusian Research Plan co-financed by the European Union (PAIDI 2020-PY20_00084) to MAB and Junta de Andalucía UMA-FEDER project (grant UMA18-FEDERJA-154) to NRL, and the Swiss National foundation to CSR (SNF 31003A_163065/1 to AM). CK was supported by a Peter und Traudl Engelhorn-Stiftung fellowship, an ETH Career Seed Grant (SEED-05 19-2) of the ETH Foundation, an Emerging Investigator grant (NNF20OC0060564) of the Novo Nordisk Foundation, and an Experiment grant (R346-2020-1546) of the Lundbeck foundation. AGM and FP were supported by BES-2015-071256 and FPU19/02219 fellowships respectively, and meeting attendance was supported by Plan Propio de Investigación, Transfe-rencia y Divulgación Científica de la Universidad de Málaga (UMA) Campus de Excelencia Internacional Andalucía Tech. VAS was supported by an Emerging Investigator research project (UMA20-FEDERJA-007) and co-financed by the “Programa Operativo FEDER 2014-2020” and by the “Consejería de Economía y Conocimiento de la Junta de Andalucía”. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectBiosíntesises_ES
dc.subjectCelulosaes_ES
dc.subjectBiomasa vegetales_ES
dc.subjectPlantas - Crecimiento - Aspectos moleculareses_ES
dc.subject.otherTTLes_ES
dc.subject.otherCellulosees_ES
dc.subject.otherPósteres_ES
dc.titleOvercoming stress: new insights in the regulation of cell wall biosynthesises_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle19th International Congress on Animal Reproduction (ICAR 2020+2)es_ES
dc.relation.eventplaceBolonia, Italiaes_ES
dc.relation.eventdateJunio 2022es_ES


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