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dc.contributor.authorRuiz-Villalba, Adrián
dc.contributor.authorHernández, Silvia C.
dc.contributor.authorAinciburu, Marina
dc.contributor.authorVilas-Zornoza, Amaia
dc.contributor.authorSudupe, Laura
dc.contributor.authorSarvide, Sarai
dc.contributor.authorPlanell, Nuria
dc.contributor.authorRipalda-Cemboráin, Purificación
dc.contributor.authorAbizanda, Gloria
dc.contributor.authorPérez-Pomares, José María 
dc.contributor.authorGómez-Cabrero, David
dc.contributor.authorPrósper, Felipe
dc.date.accessioned2022-05-31T07:13:15Z
dc.date.available2022-05-31T07:13:15Z
dc.date.created2022
dc.date.issued2022
dc.identifier.urihttps://hdl.handle.net/10630/24240
dc.description.abstractActivated cardiac fibroblasts (CFs) are responsible for the healing of the heart tissue after a myocardial infarction (MI). Based on high throughput technologies, several groups have recently demonstrated their heterogeneity and a unique role of each subpopulation of CFs during the ventricular remodelling process. This is relevant towards the discovery of personalized treatments to control the initial post-MI healing scar that will contribute to preserve ventricular function and prevent the onset of heart failure. However, little is known about the moment that CFs are activated, and which genes are potentially involved in this process. Using a mouse model for MI and single cell RNA-Seq, we demonstrate that the activation of Reparative Cardiac Fibroblasts (RCFs), the CFs responsible for the healing scar, happens within the first week after MI. Interestingly, our data reveals that all CFs show high expression of the top markers genes for RCF in a specific moment, but only few of them finally evolve to an RCF transcriptomic identity. Furthermore, we describe two different molecular dynamics that could give rise to this activation and, in consequence, the appearance of definitive RCFs. Using Spatial Transcriptomics, we localized the genes related to each dynamic in different anatomical regions of the infarcted heart, but, remarkably, only one persists seven days after MI. These results highlight the existence of a specific “window of activation” of RCFs at the beginning of the ventricular remodelling process. This potential ´therapeutical window´ could allow us to regulate the size of the healing scar and, in consequence, the poor prognosis for patients that have suffered an ischemic event.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFibrosises_ES
dc.subjectInfarto de miocardioes_ES
dc.subject.otherCardiac fibroblastses_ES
dc.subject.otherFibrosises_ES
dc.subject.otherMyocardial Infarctiones_ES
dc.titleMyocardial infarction ´through the window´: dual dynamics for cardiac fibroblasts activationes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleWeinstein Meeting 2022es_ES
dc.relation.eventplaceMarsella, Franciaes_ES
dc.relation.eventdateDel 12 al 14 de mayo de 2022es_ES
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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