FHEFD - Artículos: Envíos recientes
Mostrando ítems 1-20 de 136
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Relationship Between Mitochondrial Structure and Bioenergetics in Pseudoxanthoma elasticum Dermal Fibroblasts.
Lofaro, Francesco-Demetrio; Boraldi, Federica; García-Fernández, María Inmaculada
; Lara, Estrella; Valdivielso-Felices, Pedro; Quaglino, Daniela[et al.] (Frontiers Media, 2020-12-17)
PXE is a genetic disease considered as a paradigm of ectopic mineralization disorders, being characterized by multisystem clinical manifestations due to progressive calcification of skin, eyes, and the cardiovascular system, ... -
A new pharmacological strategy against treatment-resistant depression
Pineda-Gomez, Juan Pedro; Millón-Peñuela, Carmelo; Cantero García, Noelia; Flores, Marta; Ladrón de Guevara-Miranda, David; Flores-Burgess, Antonio; Díaz-Cabiale, Zaida[et al.] (Elsevier, 2024)
Major depressive disorder affects more than 50 million people in the world. However, 50% of patients don’t respond to two or more drugs or psychotherapeutic treatments, named treatment-resistant depression (TRD). In this ... -
Cellular aging: theories and technological influence
Mercado-Sáenz, Silvia; Ruiz-Gómez, Miguel José; Morales-Moreno, Francisco; Martínez Morillo, Manuel (Scielo Brazil, 2010-12-02)
The aim of this article was to review the factors that influence the aging, relationship of aging with the biological rhythms and new technologies as well as the main theories to explain the aging, and to analysis the ... -
Her2-Positive and Microsatellite Instability Status in Gastric Cancer—Clinicopathological Implications
Bermúdez, Ana; Arranz-Salas, Isabel María; Mercado-Sáenz, Silvia; López-Villodres, Juan Antonio; González, Virginia; Ríus-Díaz, Francisca; Ortega-Jiménez, María Victoria; Alba-Linero, Carmen; Hierro-Martín, María Isabel; Bermúdez-Flores, Diego Teófilo[et al.] (MDPI, 2021-03-21)
Gastric cancer (GC) is one of the leading causes of cancer-related death. The combination of new molecular classifications with clinicopathological data could contribute to the individualization of patients and to the ... -
Environmental Stressors on Skin Aging. Mechanistic Insights.
Parrado-Romero, Concepción; Mercado-Sáenz, Silvia; Perez-Davo, Azahara; Gilaberte, Yolanda; González, Salvador; Juarranz, Ángeles[et al.] (Frontiers, 2019-07-09)
The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they ... -
Antisense Oligonucleotides and Magnetic Nanoparticles for Targeted Diagnostic and Cancer Treatment.
Ruiz-Gómez, Miguel José; López-Díaz, Beatriz; Mercado-Sáenz, Silvia; Sendra-Portero, Francisco (MedCrave, 2017-05-31)
The resistance of tumors to therapeutic intervention is a major problem in the efficacy of treatments. A recent strategy to overcome this problem proposes the association of antitumor drugs with colloidal nanoparticles. ... -
Cambios de la composición corporal tras un periodo de desentrenamiento deportivo
Alvero-Cruz, José Ramón; Ronconi, Mauro; García-Romero, Jerónimo; Carrillo-de-Albornoz, Margarita; Jimenez Lopez, Manuel; Correas-Gómez, Lorena; Álvarez-Carnero, Elvis[et al.] (ARÁN, 2016-12)
Introducción: la influencia del ejercicio físico en sujetos entrenados tiene efectos beneficiosos en la condición física y la composición corporal. Sin embargo, el desentrenamiento tiene un efecto desfavorable en todas ... -
Respuesta endocrina a la aplicación de vibraciones de cuerpo completo en humanos
Benítez, Stefano; Carrillo-de-Albornoz, Margarita; García-Romero, Jerónimo (Elsevier, 2015-09)
La realización de ejercicio físico provoca un rompimiento de la homeostasis corporal, induciendo cambios metabólicos, neurales y humorales en el organismo de los seres humanos. Las hormonas cumplen múltiples tareas en el ... -
Autologous Human-Derived Bone Marrow Cells Exposed to a Novel TGF-β1 Fusion Protein for the Treatment of Critically Sized Tibial Defect.
Becerra-Ratia, José; Guerado-Parra, Enrique; Claros-Gil, Silvia; Alonso, Mónica; Bertrand, María L; González Plata, Carlos; Andrades-Gómez, José Antonio[et al.] (Taylor & Francis, 2006)
We report the first clinical case of transplantation of autologous bone marrow-derived cells in vitro exposed to a novel recombinant human transforming growth factor (rhTGF)-β1 fusion protein bearing a collagen-binding ... -
VO2máx de laboratorio versus Course Navette. Un estudio de concordancia en sujetos físicamente activos.
Alvero-Cruz, José Ramón; Vico Guzmán, José Francisco; Moya Medina, Miguel Ángel; Carrillo-de-Albornoz, Margarita; García-Romero, Jerónimo (Centro Andaluz de Medicina del Deporte, 2019-03-15)
Objetivo: Comprobar la concordancia entre el valor estimado de VO2máx, a partir del test de Course Navette (VO2CN), y la medición directa del consumo de oxígeno en laboratorio (VO2LAB) en un grupo de jóvenes de ambos ... -
In Vivo Bioluminescence Imaging of Cell Differentiation in Biomaterials: A Platform for Scaffold Development.
Bagó, Juli R; Aguilar, Elisabeth; Alieva, María; Soler-Botija, Carolina; Vila, Olaia F; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Becerra-Ratia, José; Rubio, Nuria; Blanco, Jerónimo[et al.] (Mary Ann Liebert, 2012-12-19)
In vivo testing is a mandatory last step in scaffold development. Agile longitudinal noninvasive real-time monitoring of stem cell behavior in biomaterials implanted in live animals should facilitate the development of ... -
Dendrimer surface orientation of the RGD peptide affects mesenchymal stem cell adhesion.
Vida-Pol, Yolanda; Collado-Martín, Daniel; Nájera-Albendín, Francisco; Claros-Gil, Silvia; Becerra-Ratia, José; Andrades-Gómez, José Antonio; Pérez-Inestrosa, Ezequiel[et al.] (Royal Society of Chemistry, 2016-05-17)
Mesenchymal stem cells (MSCs) are promising candidates for a range of tissue regeneration applications. Adequate scaffolds are necessary for their application in vivo, where interactions between cells and the surface ... -
Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity.
(Wiley, 2011)Background and purpose. The lack of safe and effective approved drugs against obesity has raised a great interest on natural products that may serve as alternative therapies. From this perspective we have addressed the ... -
The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease
Romero-Zerbo, Silvana Yanina; García-Fernández, María Inmaculada; Espinosa-Jiménez, Vanesa; Pozo-Morales, Macarena; Escamilla-Sánchez, Alejandro; Sánchez-Salido, Lourdes; Lara, Estrella; Cobo-Vuilleumier, Nadia; Rafacho, Alex; Olveira-Fuster, Gabriel María; Rojo-Martínez, Gemma; Gauthier, Benoit R.; González-Mariscal, Isabel; Bermúdez Silva, Francisco Javier[et al.] (Frontiers, 2020-03-06)
Background and Aims: The synthetic atypical cannabinoid Abn-CBD, a cannabidiol (CBD) derivative, has been recently shown to modulate the immune system in different organs, but its impact in obesity-related meta-inflammation ... -
Characterization of adult stem/progenitor cell populations from bone marrow in a three-dimensional collagen gel culture system.
Claros-Gil, Silvia; Rodríguez-Losada, Noela; Cruz, Encarnación; Guerado-Parra, Enrique; Becerra-Ratia, José; Andrades-Gómez, José Antonio[et al.] (Sage Publications, 2012-09-01)
Stem cell transplantation therapy using mesenchymal stem cells (MSCs) is considered a useful strategy. Although MSCs are commonly isolated by exploiting their plastic adherence, several studies have suggested that there ... -
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease
Romero-Zerbo, Silvana Yanina; Valverde, Nadia; Claros-Gil, Silvia; Zamorano-González, Pablo; Boraldi, Federica; Lofaro, Francesco-Demetrio; Lara, Estrella; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (Elsevier, 2024-02-08)
Introduction One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant ... -
Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment
Villatoro, Antonio J; Claros-Gil, Silvia; Fernández, Viviana; Alcoholado Cueto, Cristina; Fariñas Guerrero, Fernando; Becerra-Ratia, José; Andrades-Gómez, José Antonio[et al.] (BioMed Central, 2018)
Background: Feline eosinophilic keratitis (FEK) is a chronic keratopathy caused by a suspected immune mediated response to an unknown antigenic stimulus. The purpose of this study was to investigate the safety and therapeutic ... -
Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy
Villatoro, Antonio J; Fernández, Viviana; Claros-Gil, Silvia; Alcoholado Cueto, Cristina; Cifuentes-Rueda, Manuel; Merayo-Lloves, Jesús; Andrades-Gómez, José Antonio; Becerra-Ratia, José[et al.] (MDPI, 2017)
Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is ... -
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder
Borroto-Escuela, Dasiel; Serrano-Castro, Pedro Jesús; Sánchez-Pérez, José Andrés; Barbancho-Fernández, Miguel Ángel; Fuxe, Kjell; Narváez-Peláez, Manuel[et al.] (Taylor & Francis, 2024-04-21)
Background: Major Depressive Disorder (MDD) is a prevalent and debilitating condition, necessitating novel therapeutic strategies due to the limited efficacy and adverse effects of current treatments. We explored how galanin ... -
Large-Scale Dendrimer-Based Uneven Nanopatterns for the Study of Local RGD Density Effects on Cell Adhesion
Lagunas, Anna; Castaño, Albert G; Artés, Juan M; Vida-Pol, Yolanda; Collado-Martín, Daniel; Pérez-Inestrosa, Ezequiel; Gorostiza, Pau; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Samitier, Josep[et al.] (2014)
Cell adhesion processes are governed by the nanoscale arrangement of the extracellular matrix (ECM), being more affected by local rather than global concentrations of cell adhesive ligands. In many cell-based studies, ...