Listar FHEFD - Artículos por título
Mostrando ítems 81-100 de 136
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Lack of aprataxin impairs mitochondrial functions via downregulation of the APE1/NRF1/NRF2 pathway.
(Oxford University Press, 2015)Ataxia oculomotor apraxia type 1 (AOA1) is an autosomal recessive disease caused by mutations in APTX, which encodes the DNA strand-break repair protein aprataxin (APTX). CoQ10 deficiency has been identified in fibroblasts ... -
Large-Scale Dendrimer-Based Uneven Nanopatterns for the Study of Local RGD Density Effects on Cell Adhesion
Lagunas, Anna; Castaño, Albert G; Artés, Juan M; Vida-Pol, Yolanda
; Collado-Martín, Daniel; Pérez-Inestrosa, Ezequiel; Gorostiza, Pau; Claros-Gil, Silvia; Andrades-Gómez, José Antonio; Samitier, Josep[et al.] (2014)
Cell adhesion processes are governed by the nanoscale arrangement of the extracellular matrix (ECM), being more affected by local rather than global concentrations of cell adhesive ligands. In many cell-based studies, ... -
Laryngeal effects of stimulation of rostral and ventral pons in the anaesthetized rat
Lara-Muñoz, José Pablo; Dawid-Milner, Marc Stefan; López-González, Manuel Víctor; Montes, Carmen; Spyer, KM; González-Barón, Salvador[et al.] (Elsevier, 2002)
In order to study the importance of two pontine regions modulating laryngeal resistance, electrical current or microinjections of glutamate (10–30 nl, 1–3 nmol) were made into the pontine parabrachial complex and the A5 ... -
Longitudinal validity of abdominal adiposity assessment by regional bioelectrical impedance
Alvero-Cruz, José Ramón; García-Romero, Jerónimo; Carrillo-de-Albornoz, Margarita; Jimenez Lopez, Manuel; Correas-Gómez, Lorena; Peñaloza, Piero; López-Fernández, Iván; Álvarez-Carnero, Elvis[et al.] (Springer Nature, 2018-07-01)
The main goal of this study was to analyze the longitudinal agreement between changes in trunk and abdominal adiposity variables assessed by DXA and portable bioimpedance device (ViScan). A total of 44 women, enrolled in ... -
Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex
Garcia Diaz, Beatriz; Riquelme, Raquel; Varela Nieto, Isabel; Jiménez-Lara, Antonio Jesús; De-Diego-Barbado, Isabel; Gómez-Conde, Ana Isabel; Matas-Rico, Elisa; Aguirre-Gómez, José Ángel; Chun, Jerold; Pedraza-Benítez, María del Carmen; Santín-Núñez, Luis Javier; Fernández Fernández, Óscar; Rodriguez-de-Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Springer Link, 2014)
Lysophosphatidic acid (LPA) is an intercellular signaling lipid that regulates multiple cellular functions, acting through specific G-protein coupled receptors (LPA1–6). Our previous studies using viable Malaga variant ... -
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Cobo-Vuilleumier, Nadia; Lorenzo, Petra I; García Rodríguez, Noelia; Herrera Gómez, Irene de Gracia; Fuente-Martin, Esther; López-Noriega, Livia; Mellado-Gil, José Manuel; Romero-Zerbo, Silvana Yanina; Baquié, Mathurin; Lachaud, Christian Claude; Stifter, Katja; Perdomo, German; Bugliani, Marco; De Tata, Vincenzo; Bosco, Domenico; Parnaud, Geraldine; Pozo, David; Hmadcha, Abdelkrim; Florido, Javier P; Toscano, Miguel G; de Haan, Peter; Schoonjans, Kristina; Sánchez Palazón, Luis; Marchetti, Piero; Schirmbeck, Reinhold; Martín-Montalvo, Alejandro; Meda, Paolo; Bernat, Soria; Bermúdez Silva, Francisco Javier; St-Onge, Luc; Gauthier, Benoit R[et al.] (Nature Research, 2018)
Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited ... -
Menstrual cycle-based undulating periodized program effects on body composition and strength in trained women: a pilot studyLes effets d’un programme de périodisation ondulante, basé sur le cycle menstruel, sur la composition du corps et la force des femmes pratiquantes de musculation: une étude pilote
Vargas-Molina, Salvador; Petro, Jorge Luis; Romance-García, Ángel Ramón; Bonilla, Diego A.; Schoenfeld, Brad Jon; Kreider, Richard B.; Benítez-Porres, Javier[et al.] (ELSEVIER, 2022-06-30)
Objective To evaluate changes in body composition and strength after menstrual cycle-based or traditional undulating resistance training (RT) programs in women. Equipment and methods Ten resistance-trained and ... -
Microbiome alterations and Alzheimer's Disease: modeling strategies with transgenic mice.
López-Villodres, Juan Antonio; Escamilla-Sánchez, Alejandro; Mercado-Sáenz, Silvia; Alba-Tercedor, Carmen; Rodríguez-Pérez, Luis Manuel; Arranz-Salas, Isabel María; Sánchez-Varo, Raquel María; Bermúdez-Flores, Diego Teófilo[et al.] (MDPI, 2023-06-27)
In the last decade, the role of the microbiota-gut-brain axis has been gaining momentum in the context of many neurodegenerative and metabolic disorders, including Alzheimer's disease (AD) and diabetes, respectively. ... -
miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes.
Gentile, Adriana Mariel; Lhamyani, Said; Coín-Aragüez, Leticia I.; Clemente-Postigo, María Mercedes; Oliva Olivera, Wilfredo; Romero-Zerbo, Silvana Yanina; García Serrano, Sara; García-Escobar, Eva; Zayed, Hatem; Doblado, Esther; Bermúdez Silva, Francisco Javier; Murri, Mora; Tinahones-Madueño, Francisco José; El-Bekay, Rajaa[et al.] (Wiley, 2019)
Objective: This study aimed to analyze the potential association of different microRNA (miRNA) moleculeswith both type 2 diabetes (T2D) and obesity and determine their target genes.Methods: Quantitative PCR was used to ... -
Mitochondrial Encephalomyopathy Due to a Novel Mutation in ACAD9
(American Medical Association, 2013)Importance Mendelian forms of complex I deficiency are usually associated with fatal infantile encephalomyopathy. Application of “MitoExome” sequencing (deep sequencing of the entire mitochondrial genome and the coding ... -
Moderate exercise reveals the influence of ACTN3 R577X and ACE I/D polymorphisms on physical performance in non-athlete active subjects
Alvero-Cruz, José Ramón; Alarcón-Martín, Emilio; García-Romero, Jerónimo; Ruiz-Galdón, Maximiliano; Carrillo-de-Albornoz, Margarita; Polvillo, Rocío; González, Irene; Reyes-Engel, Armando; Royo-Sánchez-Palencia, José Luis[et al.] (Elsevier, 2023)
Genome variations contribute to the vast majority of interindividual differences and may decisively influence sports capability. This study was conceived as a means of finding out when exactly polymorphisms start being ... -
Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo
(American Association for the Advancement of Science, 2020)Remyelination failure in multiple sclerosis (MS) is associated with a migration/differentiation block of oligodendroglia. The reason for this block is highly debated. It could result from disease-related extrinsic or ... -
Neurons of the A5 region are required for the tachycardia evoked by electrical stimulation of the hypothalamic defence area in anaesthetized rats
López-González, Manuel Víctor; Díaz-Casares, Amelia; Peinado-Aragonés, Carlos Antonio; Lara-Muñoz, José Pablo; Barbancho-Fernández, Miguel Ángel; Dawid-Milner, Marc Stefan[et al.] (The Physiological Society, 2013)
In order to assess the possible interactions between the pontine A5 region and the hypothalamic defence area (HDA), we have examined the pattern of double staining for c-Fos protein immunoreactivity (c-Fos-ir) and tyrosine ... -
Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition
Beltran-Casanueva, Rasiel; Hernández-García, Aracelis; de Amo García, Paula; Blanco-Reina, Encarnación; Serrano-Castro, Pedro; García-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; Narváez, Manuel[et al.] (2024-02-14)
Introduction: This study may unveil novel insights into the interactions between neuropeptide Y receptor 1 (NPY1R) and galanin receptor 2 (GALR2), in the dentate gyrus of the dorsal hippocampus, shedding light on their ... -
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease
Romero-Zerbo, Silvana Yanina; Valverde, Nadia; Claros-Gil, Silvia; Zamorano-González, Pablo; Boraldi, Federica; Lofaro, Francesco-Demetrio; Lara, Estrella; Pavía-Molina, José; García-Fernández, María Inmaculada; Gago-Calderón, Belén; Martín-Montañez, Elisa[et al.] (Elsevier, 2024-02-08)
Introduction One of the hallmarks of Parkinsońs Disease (PD) is oxidative distress, leading to mitochondrial dysfunction and neurodegeneration. Insulin-like growth factor II (IGF-II) has been proven to have antioxidant ... -
Overexpression of Cannabinoid CB2 Receptor in the Brain Induces Hyperglycaemia and a Lean Phenotype in Adult Mice
Romero-Zerbo, Silvana Yanina; Garcia-Gutierrez, M S; Suárez-Pérez, Juan; Rivera, Patricia; Ruz-Maldonado, Inmaculada; Vida, M.; Rodriguez-de-Fonseca, Fernando; Manzanares, Jorge; Bermúdez Silva, Francisco Javier[et al.] (Blackwell Publishing Ltd, 2009)
t is well known that the endocannabinoid system, through cannabinoid CB1 receptor activation,has an important role in the main aspects of energy balance (i.e. food intake, energy expenditureand glucose and fat metabolism), ... -
Parabrachial complex glutamate receptors modulate the cardiorespiratory response evoked from hypothalamic defense area
Díaz-Casares, Amelia; López-González, Manuel Víctor; Peinado-Aragonés, Carlos Antonio; González-Barón, Salvador; Dawid-Milner, Marc Stefan (Elsevier, 2012)
To characterize the possible role of glutamate in the interaction between Hypothalamic Defense Area (HDA) and Parabrachial complex (PBc) nuclei, cardiorespiratory changes were analyzed in response to electrical stimulation ... -
Pathological, immunological and parasitological study of sheep vaccinated with the recombinant protein 14-3-3z and experimentally infected with Fasciola hepatica
Pérez-Caballero, Raúl; Siles-Lucas, Mar; González-Miguel, Javier; Martínez-Moreno, Francisco Javier; Escamilla-Sánchez, Alejandro; Pérez, José; Martinez Moreno, Álvaro; Buffoni, Leandro[et al.] (Elsevier B.V., 2018-08)
In this study, the immunogenicity and protective capacity of a new recombinant vaccine candidate, the rFh14-3-3z protein was analysed in sheep experimentally challenged with Fasciola hepatica, in terms of fluke burden, ... -
Pontine A5 region modulation of the cardiorespiratory response evoked from the midbrain dorsolateral periaqueductal grey
López-González, Manuel Víctor; González-García, Marta; Peinado-Aragonés, Carlos Antonio; Barbancho-Fernández, Miguel Ángel; Díaz-Casares, Amelia; Dawid-Milner, Marc Stefan[et al.] (Springer, 2020)
Connections between the midbrain dorsolateral periaqueductal grey (dlPAG) and the pontine A5 region have been shown. The stimulation of both regions evokes similar cardiovascular responses: tachycardia and hypertension. ... -
Potentiation of antidepressant effects: NPY1R agonist and ketamine synergy enhances TrkB signaling and neurogenesis in the ventral hippocampus
Arrabal-Gómez, Carlos; Serrano-Castro, Pedro; Sánchez-Pérez, José Andrés; Garcia-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel; Narváez, Manuel[et al.] (Taylor & Francis, 2024-04-18)
Background: Major Depressive Disorder (MDD) poses a significant challenge to global health, with current treatments often limited by efficacy and onset delays. This study explores the synergistic antidepressant-like effects ...