The aim was to analyze the psychometric properties of the Spanish version of the Gain in Alzheimer Care
Instrument (GAIN), providing validity evidence based on its internal structure, reliability, item analysis, and relationships
with other variables. A sample of 113 informal caregivers of people with dementia completed the GAIN, along with
questionnaires assessing burden, general mental health, stress, anxiety, depression, and life satisfaction. Confirmatory
factor analysis showed a single-factor structure with adequate fit indices. Reliability of GAIN scores was satisfactory, with
McDonald’s omega equal to .91. Items yielded adequate homogeneity indices. Validity evidence based on relationships
with other variables was provided by positive correlations between GAIN scores and life satisfaction, and negative
correlations with burden, general mental health problems, stress, anxiety, and depression. All these correlations were
statistically significant, and most of them were of moderate magnitude. The Spanish version of the GAIN has a single-factor
structure and satisfactory psychometric properties. It is quick and easy to apply and given the association between GAIN
scores and other variables, it may be used to provide information about a caregiver’s psychological health status.