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dc.contributor.authorNavarrete-de-Gálvez, Enrique 
dc.contributor.authorAguilera-Arjona, José 
dc.contributor.authorFonda Pascual, Pablo
dc.contributor.authorDe-Gálvez-Aranda, María Victoria 
dc.contributor.authorAndrés-Díaz, José Ramón 
dc.contributor.authorVidal Asensi, Santiago
dc.contributor.authorHerrera-Acosta, Enrique 
dc.contributor.authorGago-Calderón, Alfonso 
dc.date.accessioned2022-02-08T10:32:02Z
dc.date.available2022-02-08T10:32:02Z
dc.date.created2022
dc.date.issued2022
dc.identifier.citationGálvez EN, Aguilera J, Fonda-Pascual P, de Gálvez MV, de Andrés-Díaz JR, Vidal-Asensi S, Herrera-Acosta E, Gago-Calderon A. Analysis and evaluation of the operational characteristics of a new photodynamic therapy device. Photodiagnosis Photodyn Ther. 2022 Jan 10;37:102719. doi: 10.1016/j.pdpdt.2022.102719. Epub ahead of print. PMID: 35021108.es_ES
dc.identifier.urihttps://hdl.handle.net/10630/23762
dc.description.abstractOne of the key aspects of photodynamic therapy is the light source that is used to irradiate the lesion to be treated. The devices used must ensure that their emission spectrum matches the absorption spectrum of the photosensitizer, so that treatment radiation is delivered only on the target area, without irradiating healthy tissue at superficial or deep levels. Irradiance values must be adequate in order to avoid thermal damage, exceed the oxygen replenishment rate and avoid long treatment times. Furthermore, the device should be user-friendly, inexpensive, and able to be adapted to different photosensitizers. We have developed an easy-to-use and highly customizable device based on LED technology. Its innovative geometric design allows radiation to be delivered to a small treatment surface, since the LEDs are arranged in three arms, the configuration of which directs their radiation on the treatment point. Different high-power color LEDs are disposed on the arms, and can be independently selected based on the most effective wavelengths for exciting the different photodynamic therapy photosensitizers. We have tested the prototype in 5 different patients (1 actinic keratose, 1 actinic cheilitis, 1 superficial basal cell carcinoma and 2 Bowen's disease) and after 1-2 sessions of total cumulative dose of 25-50 J / cm2, 100% clearance of lesions were obtained. Our device can be used by any professional in the field, whether for medical or research purposes. It facilitates the development of treatment protocols and trials with different photosensitizers.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/*
dc.subjectEspectros de absorciónes_ES
dc.subjectEspectroscopía moleculares_ES
dc.subjectFotoquimioterapiaes_ES
dc.subject.otherAbsorption spectrumes_ES
dc.subject.otherEmission spectrumes_ES
dc.subject.otherLED devicees_ES
dc.subject.otherLED technologyes_ES
dc.subject.otherPhotodynamic therapy (PDT)es_ES
dc.subject.otherPhotosensitizeres_ES
dc.titleAnalysis and evaluation of the operational characteristics of a new photodynamic therapy devicees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Medicinaes_ES
dc.identifier.doihttps://doi.org/10.1016/j.pdpdt.2022.102719
dc.rights.ccAttribution-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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