Listar FP - Artículos por fecha de publicación
Mostrando ítems 1-20 de 106
-
Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions
(Wiley, 2000)Background: In nonimmediate cutaneous reactions to drugs, the skin is the organ most frequently involved, and T lymphocytes may play a relevant role. T cells related to skin immune responses express the cutaneous ... -
Anticonvulsant-induced Toxic Epidermal Necrolysis: Monitoring the Immunologic Response.
(Elsevier BV, 2000)Background Toxic epidermal necrolysis is a severe reaction with skin involvement induced by different drugs and other agents. The mechanisms implicated in the induction of the reaction are poorly understood. Objective To ... -
Subjects with allergic reactions to drugs show in vivo polarized patterns of cytokine expression depending on the chronology of the clinical reaction
(Elsevier, 2000-10)Background: The mechanisms involved in adverse drug reactions with an immunologic basis (ADRIB) can be antibody dependent, mainly IgE or T cell dependent (sensitized T cells). These mechanisms are regulated by a number of ... -
Study of binding and neutralising antibodies to interferon-β in two groups of relapsing-remitting multiple sclerosis patients.
(Springer Nature, 2001)Interferon (IFN)-β is generally considered an effective treatment for multiple sclerosis (MS); however, some patients do not respond to this therapy, possibly due to the production of neutralising antibodies (NAB) which ... -
Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests.
(Wiley, 2002)Although subjects with a positive history of immediate allergy to penicillin and negative skin test are considered to tolerate penicillin, they may develop an immediate reaction despite negative skin and serum specific IgE ... -
Delayed reactions to drugs show levels of perforin, granzyme B, and Fas-L to be related to disease severity.
(Elsevier, 2002)Background Drugs can induce different immunologic reactions; T-cell mediated responses produce the most severe reactions. Although in vitro studies show that T cells recognize drugs or their metabolites and induce an ... -
Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression
(Elsevier BV, 2004)The -330 IL2 gene promoter polymorphism has been associated with multiple sclerosis (MS) [J. Neuroimmunol. 119 (2001) 101], but the basis underlying this association remains unknown to date. In the present work, we have ... -
DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain.
(Springer, 2004-04)Background The human leukocyte antigen (HLA) class II DR2 haplotype (DRB1*1501, DQA1*0102, DQB1*0602) has been associated with multiple sclerosis (MS) in all ethnic groups and very strongly in Caucasians. Aim To investigate ... -
IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response
(Elsevier, 2005)We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFNbeta treatment response in a group of 147 patients ... -
Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis.
(Springer, 2005-03-17)Alterations in the signalling pathway that regulate T-cell tyrosine phosphorylation play an important role in MS. Tyrosine phosphorylation is regulated by the equal and balanced action of protein tyrosine kinases and protein ... -
Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug-induced idiosyncratic liver injury (DILI)
(2007-01-29)Background and purpose: The general view on the pathogenesis of drug-induced idiosyncratic liver injury (DILI) is that parent compounds are rendered hepatotoxic by metabolism, mainly by cytochrome (CYP) 450, although other ... -
In vitro T-cell responses to beta-lactam drugs in immediate and nonimmediate allergic reactions.
(Wiley, 2008)Background: Beta-Lactam drugs may induce both cellular and humoral allergic reactions, and there is evidence that T cells play an important role in the pathogenesis of these reactions. The aim of this work was to assess ... -
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations
(BMJ, 2008)Background: IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been found to be associated with systemic lupus erythematosus, rheumatoid ... -
IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
(Public Library of Science, 2009)Background:IL-2 receptor (IL2R) alpha is the specific component of the high affinity IL2R system involved in the immune response and in the control of autoimmunity. Methods and Results: Here we perform a replication and ... -
HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)
(Springer, 2009)Genetic susceptibility to multiple sclerosis (MS) is associated with genes of the major histocompatibility complex, particularly with the HLA DRB1*1501-DQA1*0102-DQB1*0602 haplotype in Caucasians. To investigate the ... -
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.
(Springer Nature, 2010)Genome-wide association studies (GWAS) have revealed that different diseases share susceptibility variants. Twelve single- nucleotide polymorphisms (SNPs) previously associated with different immune-mediated diseases in ... -
Is it possible to diagnose the therapeutic adherence of patients with COPD in clinical practice? A cohort study.
(Biomed Central LTD, 2011)The purpose of this study was to analyse the diagnostic validity of indirect adherence methods. Methods: Sample: 195 COPD patients undergoing scheduled inhaled treatment attending 5 Primary Care Centres of Malaga, Spain. ... -
Efficacy and safety of a multifactor intervention to improve therapeutic adherence in patients with chronic obstructive pulmonary disease (COPD): protocol for the ICEPOC study
(BIOMED CENTRAL LTD, 2011)Our study will evaluate the effectiveness of a multifactor intervention to improve the therapeutic adherence of COPD patients. Methods/Design: A randomized controlled clinical trial with 140 COPD diagnosed patients selected ... -
Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients
(Elsevier, 2011)Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to ... -
Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months
(SAGE Journals, 2011)Natalizumab is a monoclonal antibody shown to be highly effective in the treatment of relapsing–remitting multiple sclerosis (RRMS). Patients treated with natalizumab can develop antibodies directed against this agent that ...