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An extended reconstruction of human gut microbiota metabolism of dietary compounds.
(Springer Nature, 2021-08-05)Understanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to ... -
Management of small intestinal bacterial overgrowth by pediatric gastroenterologists in Spain.
(Arán Ediciones, 2020-12-29)Background: small intestinal bacterial overgrowth (SIBO) is a heterogeneous condition with nonspecific symptoms. This study aimed to report its management by pediatric gastroenterologists in Spain. Methods: a descriptive ... -
The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis.
(Elsevier, 2012-01-18)Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively ... -
Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn's Disease
(MDPI, 2023)Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders of the gut. The incidence and activity of IBD are determined by both genetic and environmental factors. Among these factors, polymorphisms ... -
Microbial and immune faecal determinants in infants hospitalized with COVID-19 reflect bifidobacterial dysbiosis and immature intestinal immunity
(Springer, 2023)The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide, seriously endangering human health. Although SARS-CoV-2 had a lower impact on ... -
Sirolimus for the Treatment of Juvenile Polyposis in Childhood
(Wolters Kluwer Health, 2021)Juvenile polyposis syndrome (JPS) is a rare disease with an autosomal dominant inheritance pattern characterized by the development of multiple hamartomatous polyps in the gastrointestinal tract. The most frequent signs ... -
Evaluation of atopy schools for parents
(Codon Publications, 2021)Introduction: Atopic dermatitis is a highly prevalent chronic disorder. Therapeutic education in diseases of this kind is essential in order to improve patient management and prognosis. A study was conducted regarding ... -
The New Molecules Are Changing the Course of Pediatric Chronically Active Ulcerative Colitis: A Series of Pediatric Cases
(Wiley, 2021)Chronically active ulcerative colitis (UC) constitutes a challenge in an era where medical therapeutic options have increased while experience with colectomies has decreased. The change in the therapeutic paradigm of the ... -
Herbst’s Triad as a Manifestation of Gastroesophageal Reflux Disease
(Wiley, 2021)The Herbst triad (HT) was described in 1976 by Herbst et al. (1) when detecting the association of iron deficiency anemia, hypoalbuminemia and clubbing in 3 children with hiatal hernia and severe esophagitis secondary to ... -
Innova 2020: A Follow-Up Study of the Fecal Microbiota of Infants Using a Novel Infant Formula between 6 Months and 12 Months of Age
(MDPI, 2023)The World Health Organization recommends exclusive breastfeeding until at least six months of age, with breast milk or formula being the primary food source until one year, followed by the gradual introduction of other ... -
Proactive monitoring of anti-TNF agents improves follow-up of paediatric patients with Crohn disease
(Elsevier, 2023)Introduction and aims: The incidence of paediatric inflammatory bowel disease has increased in recent decades. The aim of the present study was to evaluate the role of proactive and serial monitoring of tumour necrosis ... -
Influence of the technique and comorbidities in hypofractionated radiotherapy for prostate cancer
(Springer Link, 2020)To analyze the differences in toxicity and biochemical relapse-free survival with hypofractionated radiotherapy with three-dimensional radiotherapy (3D-CRT) or volumetric arc therapy (VMAT) for prostate cancer taking into ... -
Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months
(SAGE Journals, 2011)Natalizumab is a monoclonal antibody shown to be highly effective in the treatment of relapsing–remitting multiple sclerosis (RRMS). Patients treated with natalizumab can develop antibodies directed against this agent that ... -
Utilidad de la ecografía en el cribado del aneurisma de aorta abdominal en atención primaria.
(Elsevier, 2024-02-12)Abdominal aortic aneurysm (AAA) constitutes a pathology with high mortality. There is currently no screening program implemented in Primary care in Spain. Objectives: To evaluate the usefulness of ultrasound in the ... -
Papel de la radioterapia en los estadios iniciales del cáncer de cabeza y cuello
(Arán Ediciones, 2016)Los tumores precoces de cabeza y cuello tienen en general un buen pronóstico con un tratamiento adecuado. La radioterapia y cirugía son los dos pilares básicos del tratamiento, con resultados similares en cuanto a control ... -
Phase angle as a marker of outcome in hospitalized pediatric patients. A systematic review of the evidence (GRADE) with meta-analysis.
(Elsevier, 2023)Phase angle (PhA) is a valuable tool for evaluating the nutritional and inflammatory status, which can accompany acute and severe disorders. PhA is a cellular health biomarker, whose value is particularly substantial due ... -
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.
(Springer Nature, 2010)Genome-wide association studies (GWAS) have revealed that different diseases share susceptibility variants. Twelve single- nucleotide polymorphisms (SNPs) previously associated with different immune-mediated diseases in ... -
Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients
(Elsevier, 2011)Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to ... -
Causes of death in patients with locally advanced head and neck cancer treated with radiotherapy and systemic therapy
(BMC Springer Nature, 2019)Background: To investigate the incidence of non-cancer mortalities and prognostic factors associated with competitive causes of death in a homogeneous cohort of patients with locally advanced head and neck cancer treated ... -
Physical Activity Levels, Eating Habits, and Well-Being Measures in Students of Healthcare Degrees in the Second Year of the COVID-19 Pandemic
(MDPI, 2023)The aim of this study was to analyse the physical activity, eating habits, self-perceived well-being, and toxic habits, as well as the perceived changes of these habits with respect to the pre-pandemic period, in a population ...