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Cost-effectiveness of omalizumab in severe persistent asthma in Spain: a real-life perspective.
(Taylor & Francis, 2014-11-24)Objectives: To determine the cost-effectiveness of omalizumab compared with routine clinical practice in the treatment and control of severe persistent asthma. Methods: Cost-effectiveness analysis using pre- and ... -
Economic evaluation of a guided and unguided internet-based CBT intervention for major depression: Results from a multicenter, three-armed randomized controlled trial conducted in primary care
(Public Library of Science, 2017-02-27)The aim of this study is to analyze the cost effectiveness at 12-month follow-up of the Internet-based CBT program "Smiling is fun" with (LITG) and without psychotherapist support (TSG) compared to usual care. The perspective ... -
Cross-cultural adaptation and psychometric validation of a Spanish version of the revised Patients’ Attitudes Towards Deprescribing (rPATD) questionnaire
(BMJ, 2022-04-21)The present study was designed to validate a Spanish version of the rPATD questionnaire, both the versions for older adults and for caregivers, through a qualitative validation phase and the analysis of its psychometric ... -
Effectiveness of glatiramer acetate compared to other multiple sclerosis therapies
(Wiley Periodicals, Inc., 2015)Objective: To assess the effectiveness of glatiramer acetate (GA) compared to other multiple sclerosis (MS) therapies in routine clinical practice. Materials and methods: Observational cohort study carried out in MS ... -
The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain
(Hai Fang, Peking University, China, 2023)Therapeutic advances have made PASI 90 or PASI 100 responses possible in most patients treated with some biologics. A greater response may generate social value beyond clinical outcomes that would benefit both patients and ... -
Capturing the value of vaccination within health technology assessment and health economics: Literature review and novel conceptual framework
(Elsevier, 2022-05)The objective of this analysis was to focus on health technology assessment systems to identify relevant value concepts in order to improve current EE of non-pandemic vaccines. Methods: Following a literature review, a ... -
Public healthcare costs associated with long-term exposure to mixtures of persistent organic pollutants in two areas of Southern Spain: A longitudinal analysis.
(Elsevier, 2022-06-03)Objective: To longitudinally explore public healthcare costs associated with long-term exposure to a mixture of 8 POPs in a cohort of residents of two areas of Granada Province, Southern Spain. Methods: Longitudinal study ... -
Real‑life cost‑effectiveness of benralizumab in patients with severe asthma.
(BMC, 2021-05-27)The aim of this study was to evaluate clinical outcomes and healthcare expenditure after incorporating benralizumab into the standard treatment of refractory eosinophilic asthma. Methods: This was a cross-sectional ... -
Historical exposure to persistent organic pollutants and cardiovascular disease: A 15-year longitudinal analysis focused on pharmaceutical consumption in primary care
(Elsevier, 2021-07-02)Objectives: To explore the potential contribution of historical POP exposure to 15-year pharmaceutical consumption in relation to CVD. Methods: This study is framed within GraMo adult cohort. Participants (n = 387) were ... -
Efficacy of two educational interventions about inhalation techniques in patients with chronic obstructive pulmonary disease (COPD). TECEPOC: study protocol for a partially randomized controlled trial (preference trial)
(BMC, 2012-05-12)The objective of this study is to test the efficacy of two educational interventions to improve the inhalation techniques in patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: This study uses both a ... -
Is it possible to diagnose the therapeutic adherence of patients with COPD in clinical practice? A cohort study
(Biomed Central LTD, 2011)The purpose of this study was to analyse the diagnostic validity of indirect adherence methods. Methods: Sample: 195 COPD patients undergoing scheduled inhaled treatment attending 5 Primary Care Centres of Malaga, Spain. ... -
Efficacy of a multifactorial intervention on therapeutic adherence in patients with chronic obstructive pulmonary disease (COPD): a randomized controlled trial
(BMC, 2014)This study evaluated the effectiveness of a multifactorial intervention on improving the therapeutic adherence in chronic obstructive pulmonary disease (COPD) patients with scheduled inhalation therapy. Methods: The study ... -
Long term COST-minimization analysis of robot-assisted hysterectomy versus conventional laparoscopic hysterectomy.
(BMC, 2019-06-18)ckground: The aim of this study is to carry out the economic evaluation, in term of a cost-minimization analysis that considers healthcare costs and indirect costs, of robot-assisted hysterectomy (RAH) compared with ... -
Efficacy and safety of a multifactor intervention to improve therapeutic adherence in patients with chronic obstructive pulmonary disease (COPD): protocol for the ICEPOC study
(BIOMED CENTRAL LTD, 2011)Our study will evaluate the effectiveness of a multifactor intervention to improve the therapeutic adherence of COPD patients. Methods/Design: A randomized controlled clinical trial with 140 COPD diagnosed patients selected ... -
Profile of herbal and dietary supplements induced liver injury in Latin America: A systematic review of published reports
(WILEY, 2020-06)Hepatotoxicity related to HDS is a growing global health issue. We have undertaken a systematic review of published case reports and case series from LA from 1976 to 2020 to describe the clinical features of HDS related ... -
Insulin-like Growth Factor II Prevents MPP+ and Glucocorticoid Mitochondrial-Oxidative and Neuronal Damage in Dopaminergic Neurons
(MDPI, 2021-12-24)Stress seems to contribute to Parkinson’s disease (PD) neuropathology, probably by dysregulation of the hypothalamic–pituitary–adrenal axis. Key factors in this pathophysiology are oxidative stress and mitochondrial ... -
Herbal and dietary supplement-induced liver injuries in the spanish DILI registry
(Elsevier, 2018-01)There have been increasing reports of liver injury associated with use of herbal and dietary supplements.We collected and analyzed data on demographic and clinical features, along with biochemical parameters, of 32 patients ... -
Hepatic safety of atypical antipsychotics: current evidence and future directions
(Springer, ADIS INT LTD, 2016-10)The newer atypical antipsychotic agents (AAPs) represent an attractive therapeutic option for a wide range of psychotic disorders, including schizophrenia and bipolar mania, because of the reduced risk of disabling ... -
Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug-induced liver injury
(WILEY, 2013-04)Background & aims: Several pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene. We analysed the combined effect on drug-induced liver injury ... -
Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet
(Elsevier, 2023-12-28)In the current article the aims for a constructive way forward in Drug-Induced Liver Injury (DILI) are to highlight the most important priorities in research and clinical science, therefore supporting a more informed, ...