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Therapeutic management of idiosyncratic drug‑induced liver injury and acetaminophen hepatotoxicity in the paediatric population: a systematic review.
(Springer Nature, 2022)Introduction: Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective: We aim to comprehensively ... -
Elevated bilirubin, alkaline phosphatase at onset, and drug metabolism are associated with prolonged recovery from DILI.
(Elsevier, 2021)Background & aims: Although most drug-induced liver injury (DILI) cases resolve after the offending medication is discontinued, time to recovery varies among patients, with 6 -12% developing a chronic disease. Herein, we ... -
A revised electronic version of RUCAM for the diagnosis of DILI.
(LIPPINCOTT WILLIAMS & WILKINS, 2022-07)Roussel Uclaf Causality Assessment Method (RUCAM) for DILI has been hindered by subjectivity and poor reliability. We sought to improve the RUCAM using data from the Drug-Induced Liver Injury Network (DILIN) and the Spanish ... -
State of knowledge of the relationship between celiac disease and oral pathology: A scoping review.
(Medicina Oral S.L., 2025)Background: Celiac disease (CD) is a systemic disorder characterized by an enteropathy of highly variable clinical expression, in which the relationship with oral pathology has not yet been fully elucidated. We aimed to ... -
The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis.
(Elsevier, 2008)Some polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case–control study of three ... -
Candidate Gene Study of TRAIL and TRAIL Receptors: Association with Response to Interferon Beta Therapy in Multiple Sclerosis Patients
(Public Library of Sciences, 2013)TRAIL and TRAIL Receptor genes have been implicated in Multiple Sclerosis pathology as well as in the response to IFN beta therapy. The objective of our study was to evaluate the association of these genes in relation to ... -
2015 Beers Criteria and STOPP v2 for detecting potencially inappropriate medication in community-dwelling older people: prevalence, profile and risk factors.
(Springer, 2019-07-24)Purpose To comparatively assess the prevalence rates of potentially inappropriate medications (PIMs) obtained by the former and latest versions of American Geriatrics Society Beers Criteria (AGS BC) and screening tool of ... -
Comparison of the use of desflurane vs. propofol in aortic valve replacement surgery: Differences in nephroprotection: An Explorative and Hypothesis-Generating Study.
(MDPI, 2022-07-31)Introduction: The cardioprotective effect of halogenated drugs in cardiac surgery has been the subject of several studies. However, there is scarcity of data on their potential nephroprotective effects. Aortic valve ... -
Beyond lectures and practical courses: Teaching pharmacology using imaginative pedagogical tools.
(Elsevier, 2024-03-08)Pharmacology has broadened its scope considerably in recent decades. Initially, it was of interest to chemists, doctors and pharmacists. In recent years, however, it has been incorporated into the teaching of biologists, ... -
Prevalence and clinical conditions related to sarcopaenia among older persons living in the community.
(MDPI, 2022-07-01)Background: In health care and in society at large, sarcopaenia is a disorder of major importance that can lead to disability and other negative health-related events. Our study aim is to determine the prevalence of ... -
Assessing Prevalence and Factors Related to Frailty in Community-Dwelling Older Adults: A Multinomial Logistic Analysis.
(MDPI, 2021-08-14)Frailty is an age-related clinical condition that typically involves a deterioration in the physiological capacity of various organ systems and heightens the patient’s susceptibility to stressors. For this reason, one of ... -
Renal and neurologic benefit of levosimendan vs dobutamine in patients with low cardiac output syndrome after cardiac surgery: Clinical trial FIM-BGC-2014-01
(Frontiers Media, 2020-08-26)Background: Low-cardiac output syndrome (LCOS) after cardiac surgery secondary to systemic hypoperfusion is associated with a higher incidence of renal and neurological damage. A range of effective therapies are available ... -
Factors associated with health-related quality of life in community-dwelling older adults: a multinomial logistic analysis.
(MDPI, 2019-11-01)The main aim of this study was to determine the association of various clinical, functional and pharmacological factors with the physical (PCS) and mental (MCS) summary components of the health-related quality of life ... -
Preservation of renal function in cardiac surgery patients with low cardiac output syndrome: levosimendan vs beta agonists.
(Springer Nature, 2019-11-17)Background Some studies have been performed to assess the effects of levosimendan on cardiac function when administered to cardiac surgery patients with low cardiac output syndrome (LCOS) in the immediate postoperative ... -
Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1
(Public Library of Science, 2012)Multiple Sclerosis (MS) is the most common progressive and disabling neurological condition affecting young adults in the world today. From a genetic point of view, MS is a complex disorder resulting from the combination ... -
An extended reconstruction of human gut microbiota metabolism of dietary compounds.
(Springer Nature, 2021-08-05)Understanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to ... -
Management of small intestinal bacterial overgrowth by pediatric gastroenterologists in Spain.
(Arán Ediciones, 2020-12-29)Background: small intestinal bacterial overgrowth (SIBO) is a heterogeneous condition with nonspecific symptoms. This study aimed to report its management by pediatric gastroenterologists in Spain. Methods: a descriptive ... -
The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis.
(Elsevier, 2012-01-18)Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively ... -
Mitochondrial Stress Links Environmental Triggers with Pro-Inflammatory Signaling in Crohn's Disease
(MDPI, 2023)Inflammatory Bowel Diseases (IBD) are a group of chronic, inflammatory disorders of the gut. The incidence and activity of IBD are determined by both genetic and environmental factors. Among these factors, polymorphisms ... -
Microbial and immune faecal determinants in infants hospitalized with COVID-19 reflect bifidobacterial dysbiosis and immature intestinal immunity
(Springer, 2023)The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide, seriously endangering human health. Although SARS-CoV-2 had a lower impact on ...