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dc.contributor.authorLeón-Rodríguez, Ana
dc.contributor.authorFernández-Arjona, María del Mar
dc.contributor.authorPedraza-Benítez, María del Carmen 
dc.contributor.authorMateos-Grondona, Jesús 
dc.contributor.authorLópez-Ávalos, María Dolores 
dc.date.accessioned2021-11-09T10:01:27Z
dc.date.available2021-11-09T10:01:27Z
dc.date.created2021
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/10630/23176
dc.description.abstractAn intracerebroventricular (ICV) injection of neuraminidase (NA) within the lateral ventricles originates an acute event of neuroinflammation, which is solved to a great extent after two weeks. Recently, neurological problems or behavioral alterations have been associated with neuroinflammation. Although the majority of them fade along with inflammation resolution, the possibility of long-term sequelae should be taken into consideration. Thus, we aimed to explore if NA-induced neuroinflammation provokes behavioral or neurological disturbances at medium (2 weeks) and long (10 weeks) term. Initially, rats were ICV injected with NA or saline. Two or 10 weeks later they were made to perform a series of neurological tests and behavioral evaluations (open field test). The neuroinflammation status of the brain was studied by immunohistochemistry and qPCR. While no neurological alterations were found, the open field test revealed an increased anxiety state 2 weeks after NA administration, which was not observed after 10 weeks. In accordance with this behavioral findings, an overexpression of the molecular pattern receptor TLR4 was revealed by qPCR in hypothalamic tissue in NA treated animals after 2 weeks of ICV, but not after 10 weeks. Moreover, histological studies showed a microgliosis in the amygdala of NA injected rats 2 weeks post-ICV, as well as a slightly activated state evidenced by morphometric parameters of these cells. These histological findings were not present 10 weeks after the ICV injection. These results suggest that NA-induced neuroinflammation might cause anxiety, with no neurological manifestations, in the medium term, along with a mild microglial activation in amygdala. Such symptoms seem to revert, as they were not detected 10 weeks after NA administration.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNúcleo amigdalino - Inflamaciónes_ES
dc.subjectMicrogliaes_ES
dc.subject.otherNeuraminidasees_ES
dc.subject.otherMicrogliaes_ES
dc.subject.otherAnxietyes_ES
dc.titleNeuraminidase-induced neuroinflammation causes anxiety and microgliosis in the amygdalaes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitle19th Meeting of the Spanish Society of Neurosciencees_ES
dc.relation.eventplaceLleida (Spain)es_ES
dc.relation.eventdateNoviembre 2021es_ES


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