Listar BMB - Artículos por título
Mostrando ítems 1-20 de 168
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A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology
Carbonell-Ballesteros, Max; Durán-Nebreda, Salva; Montañez, Raúl; Macía, Javier; Rodríguez-Caso, Carlos Francisco
(Oxfrod University Press, 2014-12-16)
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly ... -
A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
(SAGE Publications, 2014-01-28)The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing microarray technology. In this study we directly compare exon microarrays to ... -
A course-based undergraduate research experience to illustrate the early stages of the drug discovery process
García-Caballero, Melissa; Moya-García, Aurelio Ángel; Torres-Vargas, José Antonio; García-Ponce, Ángel Luis; Rodríguez-Quesada, Ana María (Wiley, 2022-07-12)
We have implemented at the University of Málaga (Spain) a new course-based undergraduate research experience (CURE) to involve undergraduate students of Science in a real-world scientific problem. Within the topic “Let's ... -
A development of chimeric VEGFR2 TK inhibitor based on two ligand conformers from PDB: 1Y6A complex--medicinal chemistry consequences of a TKs analysis
Lintnerová, Lucia; García-Caballero, Melissa; Fridrich, Gregáň; Melicherčík, Milan; Rodríguez-Quesada, Ana María; Dobiaš, Juraj; Lác, Ján; Sališová, Marta; Boháč, Andrej[et al.] (Elsevier, 2014-01-24)
El VEGFR2 es un importante mediador de la angiogénesis e influye en el destino de algunas células madre cancerosas. Aquí analizamos las 34 estructuras de VEGFR2 TK disponibles en la base de datos PDB. De ellas, un complejo ... -
A morphospace for synthetic organs and organoids: the possible and the actual.
(Oxford University Press, 2016)Efforts in evolutionary developmental biology have shed light on how organs are developed and why evolution has selected some structures instead of others. These advances in the understanding of organogenesis along with ... -
A novel eIF4E-interacting protein that forms non-canonical translation initiation complexes
(Nature Research, 2019-12)Translation is a fundamental step in gene expression that regulates multiple developmental and stress responses. One key step of translation initiation is the association between eIF4E and eIF4G. This process is regulated ... -
A Proteomic Study of the Bioactivity of Annona muricata Leaf Extracts in HT-1080 Fibrosarcoma Cells.
Marrero Capitán, Ana Dácil; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Cárdenas, Casimiro (MDPI, 2023-07-27)
Graviola (Annona muricata) is a tropical plant with many traditional ethnobotanic uses and pharmacologic applications. A metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves recently allowed ... -
A revised view on the evolution of glutamine synthetase isoenzymes in plants
Valderrama-Martín, José Miguel; Ortigosa, Francisco; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Hirel, Bertrand; Cantón, Francisco R.; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2022-02)
Glutamine synthetase (GS) is a key enzyme responsible for the incorporation of inorganic nitrogen in the form of ammonium into the amino acid glutamine. In plants, two groups of functional GS enzymes are found: eubacterial ... -
Abiotic stresses differentially affect the expression of O-methyltransferase genes related to methoxypyrazine biosynthesis in seeded and parthenocarpic fruits of Vitis vinifera (L.)
(Elsevier, 2014-01-08)MPs (3-alkyl-2-methoxypyrazines) are grape-derived aroma compounds that are associated with detrimental herbaceous flavours in some wines. It is well known that several viticultural and environmental parameters can modulate ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
Allelic Variation of MYB10 is the Major Force Controlling Natural Variation of Skin and Flesh Color in Strawberry (Fragaria spp.) fruit
Castillejo, Cristina; Waurich, Veronika; Wagner, Henning; Ramos, Rubén; Oiza, Nicolás; Muñoz, Pilar; Triviño, Juan C; Caruana, Julie; Liu, Zhongchi; Cobo, Nicolás; Hardigan, Michael A; Knapp, Steven J; Vallarino Castro, José G.; Osorio-Algar, Sonia; Martín-Pizarro, Carmen; Posé-Padilla, David; Toivainen, Tuomas; Hytönen, Timo; Oh, Youngjae; Barbey, Christopher R; Whitaker, Vance M; Lee, Seonghee; Olbricht, Klaus; Sánchez-Sevilla, José F; Amaya Saavedra, Iraida[et al.] (2020-06-13)
Anthocyanins are the principal color-producing compounds synthesized in developing fruits of strawberry (Fragaria spp.). Substantial natural variation in color have been observed in fruits of diploid and octoploid accessions, ... -
Alteration of the Interconversion of Pyruvate and Malate in the Plastid or Cytosol of Ripening Tomato Fruit Invokes Diverse Consequences on Sugar But Similar Effects on Cellular Organic Acid, Metabolism, and Transitory Starch Accumulation.
Osorio-Algar, Sonia; Vallarino, José G.; Szecowka, Marek; Ufaz, Shai; Tzin, Vered; Angelovici, Ruthie; Galili, Gad; Fernie, Alisdair R.[et al.] (Oxford Academic, 2012-12-18)
The aim of this work was to investigate the effect of decreased cytosolic phosphoenolpyruvate carboxykinase (PEPCK) and plastidic NADP-dependent malic enzyme (NADP-ME) on tomato (Solanum lycopersicum) ripening. Transgenic ... -
Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance
(Springer Nature, 2023-08-20)Background: Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no ... -
AMMO-Prot: Amine system project 3D-model finder
Navas-Delgado, Ismael; Pino-Ángeles, Almudena; Montañez, Raúl; Moya-García, Aurelio Ángel; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Aldana-Montes, José Francisco[et al.] (Springer Nature, 2008-04)
Background: Amines are biogenic amino acid derivatives, which play pleiotropic and very important yet complex roles in animal physiology. For many other relevant biomolecules, biochemical and molecular data are being ... -
Ammonium regulates the development of pine roots through hormonal crosstalk and differential expression of transcription factors in the apex
Ortigosa, Francisco; Lobato-Fernández, César; Shikano, Hitomi; Ávila-Sáez, Concepción; Taira, Shu; Cánovas-Ramos, Francisco Miguel; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2021-11-01)
Ammonium is a prominent source of inorganic nitrogen for plant nutrition, but excessive amounts can be toxic for many species. However, most conifers are tolerant to ammonium, a relevant physiological feature of this ancient ... -
An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae
(Scientific Reports (Springer Nature), 2020)Senegalese sole is an economically important species in aquaculture and a model to decipher the severe transformations occurring during flatfish metamorphosis. A robust sole transcriptome was envisaged from a total of 96 ... -
An updated nomenclature for plant ribosomal protein genes
(American Society of Plant Biologists (ASPB), 2023-02-20)Proponemos a la comunidad que trabaja con plantas una nueva nomenclatura universal y homogénea para las proteínas ribosomales (y sus parálogos) -
Angioprevention of Urologic Cancers by Plant-Derived Foods.
García-Caballero, Melissa; Torres-Vargas, José Antonio; Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2022-01-21)
The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney ... -
Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero Capitán, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal-Valenzuela, Isabel; Rodríguez-Quesada, Ana María; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)
Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.
López-Jiménez, Auxiliadora; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Springer, 2013-02-01)
Antecedentes: El uso de las hojas de romero (Rosmarinus officinalis) y sus componentes como fuente de antioxidantes dietéticos y agentes aromatizantes está en continuo crecimiento. El carnosol y el ácido carnósico, dos ...