ListarBMB - Artículos por tema "Metabolic reprogramming"
Mostrando ítems 1-6 de 6
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GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells.
(MDPI, 2024-06-20)A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named ... -
Glutaminase isoenzymes in the metabolic 1 therapy of cancer
(Elsevier, 2018-07)Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine metabolism and their expression correlate with ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
(IOAP-MDPI, 2023-01-15)Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
(MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ... -
Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes.
(BenthamScience, 2020)Background: Metabolic reprogramming of tumours is a hallmark of cancer. Among the changes in the metabolic network of cancer cells, glutaminolysis is a key reaction altered in neoplasms. Glutaminase proteins control the ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
(2018-10-19)Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ...